Skip to main content

Advertisement

SpringerLink
Log in

Association study between IL-17A and IL-17F gene polymorphism and myasthenia gravis in Chinese patients

  • Original Article
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

Alleles of IL-17A and IL-17F genes were reported to be associated with many inflammatory and autoimmune disorders in Asian patients. Serum level and mRNA of IL-17A in peripheral blood mononuclear cells were reported to be significantly higher in MG patients than in healthy controls. In experimental autoimmune myasthenia gravis (EAMG) animals, IL-17 may have effects on the severity of MG. This study investigated the association between four SNPs of IL-17A and IL-17F gene (rs8193036, rs2275913 and rs3748067 in IL-17A; rs763780 in IL-17F) and MG in Chinese patients. The allele frequencies were compared between 480 MG patients and 487 healthy controls, between each MG subgroup and the control group, and between each pairs of MG subgroups. Subgroups were specified by clinical features (onset age, gender, thymoma, AChRAb and muscle involvement at onset) and maximal severity during the follow-up. No associations were found between the four SNPs of IL-17A and IL-17F gene and MG in Chinese patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Meriggioli MN, Sanders DB (2009) Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity. Lancet Neurol 8(5):475–490

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  2. Iwakura Y, Ishigame H, Saijo S et al (2011) Functional specialization of interleukin-17 family members. Immunity 34(2):149–162

    Article  PubMed  CAS  Google Scholar 

  3. Wang ZK, Wang W, Chen YP et al (2012) Thymoma T helper type 17 cells and related cytokines in myasthenia gravis. Zhonghua Nei Ke Za Zhi 51(7):540–542

    PubMed  CAS  Google Scholar 

  4. Mu L, Sun B, Kong Q et al (2009) Disequilibrium of T helper type 1, 2 and 17 cells and regulatory T cells during the development of experimental autoimmune myasthenia gravis. Immunology 128(1 Suppl):e826–e836

    Article  PubMed  PubMed Central  Google Scholar 

  5. Giraud M, Vandiedonck C, Garchon HJ (2008) Genetic factors in autoimmune myasthenia gravis. Ann N Y Acad Sci 1132:180–192

    Article  PubMed  CAS  Google Scholar 

  6. Hayashi R, Tahara T, Shiroeda H et al (2013) Influence of IL17A polymorphisms (rs2275913 and rs3748067) on the susceptibility to ulcerative colitis. Clin Exp Med 13(4):239–244

    Article  PubMed  CAS  Google Scholar 

  7. Wang JY, Shyur SD, Wang WH et al (2009) The polymorphisms of interleukin 17A (IL17A) gene and its association with pediatric asthma in Taiwanese population. Allergy 64(7):1056–1060

    Article  PubMed  CAS  Google Scholar 

  8. Yan N, Yu YL, Yang J et al (2012) Association of interleukin-17A and -17F gene single-nucleotide polymorphisms with autoimmune thyroid diseases. Autoimmunity 45(7):533–539

    Article  PubMed  CAS  Google Scholar 

  9. Wang H, Zhong X, Wang K et al (2012) Interleukin 17 gene polymorphism is associated with anti-aquaporin 4 antibody-positive neuromyelitis optica in the Southern Han Chinese—a case control study. J Neurol Sci 314(1–2):26–28

    Article  PubMed  CAS  Google Scholar 

  10. Aarli JA (2008) Myasthenia gravis in the elderly: is it different? Ann N Y Acad Sci 1132:238–243

    Article  PubMed  Google Scholar 

  11. Skeie GO, Pandey JP, Aarli JA et al (1999) TNFA and TNFB polymorphisms in myasthenia gravis. Arch Neurol 56(4):457–461

    Article  PubMed  CAS  Google Scholar 

  12. Grob D, Brunner N, Namba T et al (2008) Lifetime course of myasthenia gravis. Muscle Nerve 37(2):141–149

    Article  PubMed  Google Scholar 

  13. Chen X, Li S, Yang Y et al (2012) Genome-wide association study validation identifies novel loci for atherosclerotic cardiovascular disease. J Thromb Haemost 10(8):1508–1514

    Article  PubMed  CAS  Google Scholar 

  14. Laird NM, Lange C (2011) The fundamentals of modern statistical genetics. Springer, Berlin, pp 101–107

  15. Barrett JC, Fry B, Maller J et al (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263–265

    Article  PubMed  CAS  Google Scholar 

  16. Skeie GO, Romi F (2008) Paraneoplastic myasthenia gravis: immunological and clinical aspects. Eur J Neurol 15(10):1029–1033

    Article  PubMed  CAS  Google Scholar 

  17. Marx A, Willcox N, Leite MI et al (2010) Thymoma and paraneoplastic myasthenia gravis. Autoimmunity 43(5–6):413–427

    Article  PubMed  CAS  Google Scholar 

  18. Korn T, Bettelli E, Oukka M et al (2009) IL-17 and Th17 cells. Annu Rev Immunol 27:485–517

    Article  PubMed  CAS  Google Scholar 

  19. Oosterhuis HJ, Limburg PC, Hummel-Tappel E et al (1983) Anti-acetylcholine receptor antibodies in myasthenia gravis. Part 2. Clinical and serological follow-up of individual patients. J Neurol Sci 58(3):371–385

    Article  PubMed  CAS  Google Scholar 

  20. Lu J, Huang Y, Lu JH et al (2010) The change and relevant significance of Th1/Th2/Th17 cytokines in Myasthenia Gravis. Chin J Clin Neurosci 18(5):480–484

    Google Scholar 

Download references

Acknowledgments

This study is supported by the National Natural Science Foundation of China (Grant No. 81070963, 30700242) and Natural Science Foundation of Shandong Province (Grant No. ZR2010HM019). We thank Genesky Biotechnologies Inc., Shanghai, China, for technical support.

Author information

Author notes

    Authors and Affiliations

    1. Department of Neurology, Qilu Hospital of Shandong University, 107 Wenhua West Road, 250012, Jinan, China

      Yao-Xian Yue & Hai-Feng Li

    2. Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China

      Yu Hong, Chuan-Kai Gu, Xu Zhang, Xiang Gao, Tian-Ping Tang, Xian-Jun Zhang & Qi Wang

    3. Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

      Yanchen Xie

    4. Laboratory of Neuroimmunology, Department of Neurology, Peking University First Hospital, Beijing, China

      Hong-Jun Hao

    5. College of Information and Engineering, Qingdao University, Qingdao, China

      Yi Sui

    Authors
    1. Yao-Xian Yue
      View author publications

      You can also search for this author in PubMed Google Scholar

    2. Yu Hong
      View author publications

      You can also search for this author in PubMed Google Scholar

    3. Yanchen Xie
      View author publications

      You can also search for this author in PubMed Google Scholar

    4. Hong-Jun Hao
      View author publications

      You can also search for this author in PubMed Google Scholar

    5. Yi Sui
      View author publications

      You can also search for this author in PubMed Google Scholar

    6. Chuan-Kai Gu
      View author publications

      You can also search for this author in PubMed Google Scholar

    7. Xu Zhang
      View author publications

      You can also search for this author in PubMed Google Scholar

    8. Xiang Gao
      View author publications

      You can also search for this author in PubMed Google Scholar

    9. Tian-Ping Tang
      View author publications

      You can also search for this author in PubMed Google Scholar

    10. Xian-Jun Zhang
      View author publications

      You can also search for this author in PubMed Google Scholar

    11. Qi Wang
      View author publications

      You can also search for this author in PubMed Google Scholar

    12. Hai-Feng Li
      View author publications

      You can also search for this author in PubMed Google Scholar

    Corresponding author

    Correspondence to Hai-Feng Li.

    Ethics declarations

    Conflict of interest

    No potential conflict of interest relevant to this article was reported.

    Additional information

    Y.-X. Yue and Y. Hong contribute equally to this article.

    Rights and permissions

    Reprints and permissions

    About this article

    Check for updates. Verify currency and authenticity via CrossMark

    Cite this article

    Yue, YX., Hong, Y., Xie, Y. et al. Association study between IL-17A and IL-17F gene polymorphism and myasthenia gravis in Chinese patients. Neurol Sci 37, 123–130 (2016). https://doi.org/10.1007/s10072-015-2375-y

    Download citation

    • Received:

    • Accepted:

    • Published:

    • Issue Date:

    • DOI: https://doi.org/10.1007/s10072-015-2375-y

    Keywords

    Search

    Navigation