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Cerebrospinal fluid cathepsin B and S

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Abstract

Cathepsins are increased in the brain of elderly animals. We investigate the presence of cathepsin B and S in human cerebrospinal fluid (CSF) plasma and the associations with cystatin C, age and sex. We measured cathepsin B and S concentrations in CSFs from 118 persons, undergoing elective surgical procedures, with ELISA. Both cathepsin B and cathepsin S were positively correlated with age. No correlation was observed between cathepsin B or S and length, height or body mass index. Both cathepsin B and S were positively correlated to the cystatin C concentration in CSF. Calculated reference intervals were 4,893–17,636 pg/mL for cathepsin B and 2,681–11,459 pg/mL for cathepsin S. Elderly individuals had significantly higher levels of both cathepsin B (r s = 0.38, p = 0.00002) and cathepsin S (r s = 0.35, p = 0.0001) in CSF.

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Acknowledgments

This study was financially supported by the Uppsala University Hospital Research Fund and Uppsala Berzelii center.

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Authors and Affiliations

  1. Department of Medical Sciences, Clinical Chemistry, Uppsala University Hospital, 751 85, Uppsala, Sweden

    Elin Nilsson & Anders Larsson

  2. Department of Anaesthesia and Intensive Care, University of Cluj Napoca, Cluj Napoca, Romania

    Constantin Bodolea

  3. Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden

    Torsten Gordh

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  1. Elin Nilsson
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  2. Constantin Bodolea
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  3. Torsten Gordh
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  4. Anders Larsson
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Correspondence to Anders Larsson.

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Nilsson, E., Bodolea, C., Gordh, T. et al. Cerebrospinal fluid cathepsin B and S. Neurol Sci 34, 445–448 (2013). https://doi.org/10.1007/s10072-012-1022-0

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  • DOI: https://doi.org/10.1007/s10072-012-1022-0

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