Abstract
We aimed to investigate the prevalence of cardiac right left shunts (RLS) in population-based samples of subjects with migraine with aura (n = 42), migraine without aura (n = 44) and controls without headache (n = 41). Cardiac RLS was assessed with transcranial Doppler sonography with intravenous injection of saline. Prevalence of RLS was highest in migraineurs with aura (45.2%) compared to migraineurs without aura (34.1%) and controls (41.5%). Permanent as opposed to latent RLS was more common among patients with migraine with aura (40.5%) than in patients with migraine without aura (23.3%) or controls (24.4%). Differences did not reach statistical significance between the three groups (p = 0.564 for RLS prevalence, p = 0.349 for prevalence of permanent shunts). Our data implicate a trend towards higher prevalence of RLS with larger shunts in subjects with migraine with aura.
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References
Diener HC, Kurth T, Dodick D (2007) Patent foramen ovale and migraine. Curr Pain Headache Rep 11:236–240
Rundek T, Elkind MSV, Di Tullio MR et al (2008) Patent foramen ovale and migraine: a cross-sectional study from the Northern Manhattan Study (NOMAS). Circulation 118:1419–1424
Katsarava Z, Manack A, Yoon M-S et al (2011) Chronic migraine: classification and comparisons. Cephalalgia 31:520–529
Yoon M-S, Obermann M, Fritsche G et al (2008) Population-based validation of a German-language self-administered headache questionnaire. Cephalalgia 28:605–608
Carod-Artal FJ, da Silveira RibeiroL, Braga H, Kummer W, Mesquita HM, Vargas AP (2006) Prevalence of patent foramen ovale in migraine patients with and without aura compared with stroke patients. A transcranial Doppler study. Cephalalgia 26:934–939
Droste DW, Lakemeier S, Wichter T et al (2002) Optimizing the technique of contrast transcranial Doppler ultrasound in the detection of right-to-left shunts. Stroke 33:2211–2216
Del Sette M, Angeli S, Leandri M et al (1998) Migraine with aura and right-to-left shunt on transcranial Doppler: a case–control study. Cerebrovasc Dis 8:327–330
Schwerzmann M, Nedeltchev K, Lagger F et al (2005) Prevalence and size of directly detected patent foramen ovale in migraine with aura. Neurology 65:1415–1418
Dalkara T, Nozari A, Moskowitz MA (2010) Migraine aura pathophysiology: the role of blood vessels and microembolisation. Lancet Neurol 9:309–317
Rigatelli G (2010) Congenital heart conditions: the “headache” of assessing a link between PFO and migraine. Nat Rev Cardiol 7:361–362
Hagen PT, Scholz DG, Edwards WD (1984) Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts. Mayo Clin Proc 59:17–20
Manzoni GC, Stovner LJ (2010) Epidemiology of headache. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, 97th edn. Elsevier, Amsterdam, pp 3–22
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The study was supported by the German Federal Ministry for Education and Research (BMBF).
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Küper, M., Rabe, K., Holle, D. et al. Prevalence of cardiac right left shunts in migraine: a population-based case–control study. Neurol Sci 34, 205–208 (2013). https://doi.org/10.1007/s10072-012-0986-0
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DOI: https://doi.org/10.1007/s10072-012-0986-0