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Long-term efficacy of autologous haematopoietic stem cell transplantation in multiple sclerosis at a single institution in China

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Abstract

Autologous haematopoietic stem cell transplantation (AHSCT) is a promising treatment for multiple sclerosis (MS) patients who have not adequately responded to conventional therapies. We retrospectively evaluated the safety and long-term clinical outcome of AHSCT in MS patients in China. Twenty-five patients with various types of MS were treated with AHSCT. Peripheral blood stem cells were derived by leukapheresis after mobilized with granulocyte colony-stimulating factor. Then CD34+ cell selection of the graft was performed and anti-thymocyte globulin was given for T-cell depletion, with the conditioning regimen BEAM adopted and early and late toxicities recorded. Long-term responses were evaluated by the expanded disability status scale (EDSS), progression-free survival and gadolinium-enhanced magnetic resonance imaging scans. 10, 7 and 8 patients experienced neurological improvement, stabilization and progression, respectively. The median EDSS scores observed over 1-year follow-up after transplantation (5.5–7.0) were consistently lower than the baseline (8.0). The progression-free survival rate was 74, 65 and 48% at 3, 6 and 9 years post-transplant. 58% cases (7/12) had active lesions at baseline and all turned to inactive status in the years of follow-up. 25% cases (3/12) experienced progression after transplantation but had no active lesions in MRI over the whole follow-up period. 17% cases (2/12) without active lesions at baseline progressed active lesions in MRI. The major early toxicity resulted in fever and late toxicity caused transplantation-related mortality due to severe pneumonia and varicella-zoster virus hepatitis, respectively. AHSCT is a feasible treatment for severe MS and its long-term efficacy is favorable.

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Acknowledgment

This work was supported by the Project of Jiangsu Province’s Laboratory of Clinical Immunology (NO.2003-19).

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Authors and Affiliations

  1. Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, People’s Republic of China

    Bing Chen, Min Zhou, Jian Ouyang, Rongfu Zhou, Jingyan Xu, Qiguo Zhang, Yonggong Yang, Yong Xu, Xiaoyan Shao, Li Meng, Jing Wang & Xueguang Zhang

  2. Center of Bone Marrow Transplantation, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China

    Bing Chen, Min Zhou, Jian Ouyang, Rongfu Zhou, Jingyan Xu, Qiguo Zhang, Yonggong Yang, Yong Xu, Xiaoyan Shao, Li Meng, Jing Wang & Xueguang Zhang

  3. Department of Neurology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China

    Yun Xu & Xiushi Ni

Authors
  1. Bing Chen
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  2. Min Zhou
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  3. Jian Ouyang
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  4. Rongfu Zhou
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  5. Jingyan Xu
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  6. Qiguo Zhang
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  7. Yonggong Yang
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  8. Yong Xu
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  9. Xiaoyan Shao
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  10. Li Meng
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  11. Jing Wang
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  12. Yun Xu
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  13. Xiushi Ni
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  14. Xueguang Zhang
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Corresponding author

Correspondence to Jian Ouyang.

Additional information

M. Zhou and B. Chen contribute equally to this article and should be considered as co-first authors.

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Chen, B., Zhou, M., Ouyang, J. et al. Long-term efficacy of autologous haematopoietic stem cell transplantation in multiple sclerosis at a single institution in China. Neurol Sci 33, 881–886 (2012). https://doi.org/10.1007/s10072-011-0859-y

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  • DOI: https://doi.org/10.1007/s10072-011-0859-y

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