Neurological Sciences

, 32:165

Interictal cortical reorganization in episodic migraine without aura: an event-related fMRI study during parametric trigeminal nociceptive stimulation

  • A. Tessitore
  • A. Russo
  • F. Esposito
  • A. Giordano
  • G. Taglialatela
  • R. De Micco
  • M. Cirillo
  • F. Conte
  • F. d’Onofrio
  • S. Cirillo
  • Gioacchino Tedeschi
Brief Communication

DOI: 10.1007/s10072-011-0537-0

Cite this article as:
Tessitore, A., Russo, A., Esposito, F. et al. Neurol Sci (2011) 32: 165. doi:10.1007/s10072-011-0537-0

Abstract

The aim of our study was to explore the pain processing network in patients with migraine during trigeminal nociceptive stimulation. Sixteen patients with episodic migraine without aura and 16 healthy controls performed functional magnetic resonance imaging during thermal stimuli (at 41, 51 and 53°C). Patients with migraine showed a greater activation in the perigenual part of anterior cingulate cortex at 51°C and less activation in the bilateral somatosensory cortex at 53°C compared to healthy controls. There were no differences in experimental pain perception between groups. Our findings demonstrate a functional reorganization of cerebral areas known to be involved in pain processing in patients with migraine.

Keywords

fMRIMigrainePain processingAnterior cingulate and somatosensory cortices

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • A. Tessitore
    • 1
  • A. Russo
    • 1
    • 2
  • F. Esposito
    • 2
    • 3
  • A. Giordano
    • 1
    • 2
  • G. Taglialatela
    • 1
  • R. De Micco
    • 1
  • M. Cirillo
    • 1
  • F. Conte
    • 1
  • F. d’Onofrio
    • 4
  • S. Cirillo
    • 1
    • 2
  • Gioacchino Tedeschi
    • 1
    • 2
  1. 1.Department of Neurological SciencesSecond University of NaplesNaplesItaly
  2. 2.Institute for Diagnosis and Care “Hermitage Capodimonte”NaplesItaly
  3. 3.Department of NeuroscienceUniversity of Naples “Federico II”NaplesItaly
  4. 4.Neurology UnitSG Moscati HospitalAvellinoItaly