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White tea (Camellia sinenesis (L.)) ethanol extracts attenuate reserpine-induced gastric ulcers in mice

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Abstract

The gastroprotective effect of white tea extract ethanol (WTEE) on reserpine induced gastric ulcers in KM mice was investigated. Gastric juice secretion, the pH of gastric juice, serum neuropeptides, including motilin (MOT), substance P (SP), vasoactive intestinal peptide (VIP), and somatostatin (SS) levels, and serum levels of the inflammatory cytokines TNF-α, IL-6, IL-12, and IFN-γ were measured. WTEE dose-dependently reduced reserpine-induced gastric juice secretion and increased the pH of gastric juice. WTEE increased serum levels of VIP and SS and reduced levels of MOT, SP, and inflammatory cytokines in the serum. WTEE modulated gastric expression of occludin and p38 phosphorylation in ulcer-bearing mice. WTEE has a gastroprotective effect against reserpine-induced gastric ulcers in KM mice via reduction of gastric juice secretion, modulation of serum neuropeptide levels, attenuation of serum inflammatory cytokines, and regulation of gastric levels of occludin and p38 phosphorylation.

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Authors and Affiliations

  1. Department of Nutrition and Food Hygiene, School of Public Health, Guilin Medical University, Guilin, Guangxi, 541004, China

    Jia-Le Song

  2. Department of Food Science and Nutrition, Busan National University, Busan, 609-735, Korea

    Jia-Le Song

  3. Institute of Functional Ecological Food, Chongqing University of Education, Chongqing, 400067, China

    Jia-Le Song & Xin Zhao

  4. Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, 400067, China

    Yalin Zhou, Xia Feng & Xin Zhao

Authors
  1. Jia-Le Song
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  2. Yalin Zhou
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  3. Xia Feng
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  4. Xin Zhao
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Correspondence to Xin Zhao.

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Song, JL., Zhou, Y., Feng, X. et al. White tea (Camellia sinenesis (L.)) ethanol extracts attenuate reserpine-induced gastric ulcers in mice. Food Sci Biotechnol 24, 1159–1165 (2015). https://doi.org/10.1007/s10068-015-0148-2

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  • DOI: https://doi.org/10.1007/s10068-015-0148-2

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