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Transbronchial lung cryobiopsy for connective tissue disease–related interstitial lung disease and interstitial pneumonia with autoimmune features: a single center retrospective case series

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Abstract

Objective

Transbronchial lung cryobiopsy (TBLC) has been recently introduced for diagnosing interstitial lung diseases. We aimed to assess the effectiveness and safety of TBLC by identifying the specific patterns of histology in the diagnosis of connective tissue disease–related interstitial lung disease (CTD-ILD) and interstitial pneumonia with autoimmune features (IPAF).

Methods

The clinical-radiological-pathological data from the Affiliated Hospital of Guilin Medical University between July 1, 2017, and October 31, 2020, of patients whose clinical-radiological or clinical-radiological-pathological diagnosis was CTD-ILD or IPAF and who underwent TBLC, transbronchial lung biopsy (TBLB), or surgical lung biopsy were retrospectively analyzed and summarized with review. The size of biopsy samples, complications, and diagnostic yield were compared.

Results

Fourteen patients met the inclusion criteria, of whom 12 underwent TBLC, 1 underwent TBLB, and 1 underwent each procedure at different times. Compared to the size of TBLB specimens (5.625 ± 0.479 mm2), the size of TBLC specimens (12.00 (12.00, 15.00) mm2) was much larger (Z = − 3.262, P = 0.001). The diagnostic yields of TBLC and TBLB were 100.00% (13/13) and 0.00% (2/2), respectively (P = 0.0095). The most frequent complication was mild bleeding. The risk of bleeding between TBLB (1/2, 50.00%) and TBLC (10/13, 76.92%) did not differ significantly (P = 0.469).

Conclusion

TBLC can add extra diagnostic value by effectively identifying specific types of histology for patients with suspected CTD-ILD or IPAF, with a procedure that is safe from adverse events.

Key Points

• Transbronchial lung cryobiopsy has been introduced recently for diagnosing interstitial lung disease.

• Transbronchial lung cryobiopsy was found to be effective and safe in the diagnosis for patients with suspected interstitial lung disease. It can be used as a preferred method for biopsy when the clinical-radiological diagnosis is uncertain.

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Acknowledgements

We would like to express our gratitude to our colleagues at The Affiliated Hospital of Guilin Medical University and to the associate editor and the reviewers for their useful feedback that improved this paper.

Funding

This work was supported by funds from the National Natural Science Foundation of China Grant 81760298 and the 139 Program for the High-Level Medical Talents in Guangxi Province.

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Authors and Affiliations

  1. Department of Rheumatology, Guilin Medical University, Guilin, Guangxi, China

    Wen-jue Wu, Han-You Mo & Hong Liu

  2. Department of Rheumatology, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China

    Han-You Mo

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Correspondence to Han-You Mo.

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Wu, Wj., Mo, HY. & Liu, H. Transbronchial lung cryobiopsy for connective tissue disease–related interstitial lung disease and interstitial pneumonia with autoimmune features: a single center retrospective case series. Clin Rheumatol 40, 3765–3772 (2021). https://doi.org/10.1007/s10067-021-05671-1

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