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Relatives’ quality of life and psychological disturbance: a new concern of SLE management

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Abstract

It is known that the quality of life (QOL) and psychological status of patients with systemic lupus erythematosus (SLE) are severely impaired. However, a few reports have assessed the QOL and psychological status in relatives of these patients. This study aimed to assess the QOL and psychological status in relatives of patients with SLE and their impact on patients. A total of 104 patient–relative dyads were evaluated using a 36-Item Short-Form Survey (SF-36), Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7), and Social Support Rating Scale (SSRS). Relatives of patients with SLE exhibited an impaired QOL compared with the general population (69.59 ± 22.78 vs 78.18 ± 15.88, P < 0.001) and suffered from depression (5.8 ± 5.4) and anxiety (5.8 ± 6.0). GAD-7 of relatives was positively correlated with GAD-7 of patients (r = 0.210, P < 0.05). Patients reported a lower global SF-36 score when their relatives had lower global SF-36 scores (50.13 ± 19.18 vs 58.44 ± 19.67, P < 0.05) and significantly higher SSRS when their relatives had lower PHQ-9 (41.9 ± 8.7 vs 36.3 ± 6.2, P < 0.01) or GAD-7 scores (42.8 ± 7.4 vs 36.7 ± 6.6, P < 0.01). The QOL and psychological status in relatives of patients with SLE were adversely impaired. Associations exist between the QOL and psychological status of relatives and patients with SLE. Therefore, both patients and their relatives should be taken into account when making management decisions.

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References

  1. Wang Z, Wang Y, Zhu R et al (2015) Long-term survival and death causes of systemic lupus erythematosus in China: a systemic review of observational studies. Medicine 94:e794. doi:10.1097/MD.0000000000000794

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Shakeri H, Arman F, Hossieni M et al (2015) Depression, anxiety and disease-related variables and quality of life among individuals with systemic lupus erythematosus living in Kermanshah Province, Iran. Iran Red Crescent Med J 17:e31047. doi:10.5812/ircmj.31047

    PubMed  PubMed Central  Google Scholar 

  3. Van Vollenhoven RF, Mosca M, Bertsias G et al (2014) Treat-to-target in systemic lupus erythematosus: recommendations from an international task force. Ann Rheum Dis 73:958–967. doi:10.1136/annrheumdis-2013-205139

    Article  PubMed  Google Scholar 

  4. Stenberg U, Ruland CM, Miaskowski C (2010) Review of the literature on the effects of caring for a patient with cancer. Psychooncology 19:1013–1025. doi:10.1002/pon.1670

    Article  PubMed  Google Scholar 

  5. Grunfeld E, Coyle D, Whelan T et al (2004) Family caregiver burden: results of a longitudinal study of breast cancer patients and their principal caregivers. CMAJ 170:1795–1801

    Article  PubMed  PubMed Central  Google Scholar 

  6. Lim J, Zebrack B (2004) Caring for family members with chronic physical illness: a critical review of caregiver literature. Health Qual Life Outcomes 2:50. doi:10.1186/1477-7525-2-50

    Article  PubMed  PubMed Central  Google Scholar 

  7. Park B, Kim SY, Shin J-Y et al (2013) Prevalence and predictors of anxiety and depression among family caregivers of cancer patients: a nationwide survey of patient-family caregiver dyads in Korea. Support Care Cancer 21:2799–2807. doi:10.1007/s00520-013-1852-1

    Article  PubMed  Google Scholar 

  8. Anaforoğlu I, Ramazanoğulları I, Algün E, Kutanis R (2012) Depression, anxiety and quality of life of family caregivers of patients with type 2 diabetes. Med Princ Pract 21:360–365. doi:10.1159/000334622

    Article  PubMed  Google Scholar 

  9. Press J, Neumann L, Uziel Y et al (2002) Assessment of quality of life of parents of children with juvenile chronic arthritis. Clin Rheumatol 21:280–283. doi:10.1007/s100670200074

    Article  CAS  PubMed  Google Scholar 

  10. Jolly M, Thakkar A, Mikolaitis RA, Block JA (2015) Caregiving, dyadic quality of life and dyadic relationships in lupus. Lupus 24:918–926. doi:10.1177/0961203314567749

    Article  CAS  PubMed  Google Scholar 

  11. Al Sawah S, Daly RP, Foster SA et al (2017) The caregiver burden in lupus: findings from UNVEIL, a national online lupus survey in the United States. Lupus 26:54–61. doi:10.1177/0961203316651743

    Article  PubMed  Google Scholar 

  12. Okamoto K, Harasawa Y (2009) Emotional support from family members and subjective health in caregivers of the frail elderly at home in Japan. Arch Gerontol Geriatr 49:138–141. doi:10.1016/j.archger.2008.06.003

    Article  PubMed  Google Scholar 

  13. Bombardier C, Gladman DD, Urowitz MB et al (1992) Derivation of the SLEDAI. A disease activity index for lupus patients. The committee on prognosis studies in SLE. Arthritis Rheum 35:630–640

    Article  CAS  PubMed  Google Scholar 

  14. McHorney CA, Ware JE, Lu JF, Sherbourne CD (1994) The MOS 36-item Short-Form health survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Med Care 32:40–66

    Article  CAS  PubMed  Google Scholar 

  15. Kroenke K, Spitzer RL, Williams JB (2001) The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 16:606–613

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Manea L, Gilbody S, McMillan D (2015) A diagnostic meta-analysis of the patient health Questionnaire-9 (PHQ-9) algorithm scoring method as a screen for depression. Gen Hosp Psychiatry 37:67–75. doi:10.1016/j.genhosppsych.2014.09.009

    Article  PubMed  Google Scholar 

  17. Wang W, Bian Q, Zhao Y et al (2014) Reliability and validity of the Chinese version of the patient health Questionnaire (PHQ-9) in the general population. Gen Hosp Psychiatry 36:539–544. doi:10.1016/j.genhosppsych.2014.05.021

    Article  PubMed  Google Scholar 

  18. Spitzer RL, Kroenke K, Williams JBW, Löwe B (2006) A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med 166:1092–1097. doi:10.1001/archinte.166.10.1092

    Article  PubMed  Google Scholar 

  19. Schalet BD, Cook KF, Choi SW, Cella D (2014) Establishing a common metric for self-reported anxiety: linking the MASQ, PANAS, and GAD-7 to PROMIS anxiety. J Anxiety Disord 28:88–96. doi:10.1016/j.janxdis.2013.11.006

    Article  PubMed  Google Scholar 

  20. Ying DG-C, Jiang S, Yang H, Zhu S (2010) Frequency of generalized anxiety disorder in Chinese primary care. Postgrad Med 122:32–38. doi:10.3810/pgm.2010.07.2173

    Article  PubMed  Google Scholar 

  21. Xiao SY (1993) The social support rate scale. Chin J Psychol 7:42–46

    Google Scholar 

  22. Zhu YB, Wang Q, Chen KF et al (2009) Predictors of health-related quality of life in the general population. Chin J Behav Med Brian Sci 18:254–259 (in Chinese)

    Google Scholar 

  23. Wang WZ (2014) Psychological health status in seven provinces in China and brief intervention for alcohol abuse. (in Chinese)

  24. Yilmaz-Oner S, Oner C, Dogukan FM et al (2015) Anxiety and depression predict quality of life in Turkish patients with systemic lupus erythematosus. Clin Exp Rheumatol 33:360–365

    PubMed  Google Scholar 

  25. Xie H, Cheng C, Tao Y et al (2016) Quality of life in Chinese family caregivers for elderly people with chronic diseases. Health Qual Life Outcomes 14:99. doi:10.1186/s12955-016-0504-9

    Article  PubMed  PubMed Central  Google Scholar 

  26. Friðriksdóttir N, Saevarsdóttir T, Halfdánardóttir SÍ et al (2011) Family members of cancer patients: needs, quality of life and symptoms of anxiety and depression. Acta Oncol 50:252–258. doi:10.3109/0284186X.2010.529821

    Article  PubMed  Google Scholar 

  27. McLean CP, Asnaani A, Litz BT, Hofmann SG (2011) Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness. J Psychiatr Res 45:1027–1035. doi:10.1016/j.jpsychires.2011.03.006

    Article  PubMed  PubMed Central  Google Scholar 

  28. Zheng Y, Ye D-Q, Pan H-F et al (2009) Influence of social support on health-related quality of life in patients with systemic lupus erythematosus. Clin Rheumatol 28:265–269. doi:10.1007/s10067-008-1033-7

    Article  PubMed  Google Scholar 

  29. Alarcón GS, Calvo-Alén J, McGwin G et al (2006) Systemic lupus erythematosus in a multiethnic cohort: LUMINA XXXV. Predictive factors of high disease activity over time. Ann Rheum Dis 65:1168–1174. doi:10.1136/ard.200X.046896

    Article  PubMed  PubMed Central  Google Scholar 

  30. Kross EK, Curtis JR (2008) Burden of psychological symptoms and illness in family of critically ill patients: what is the relevance for critical care clinicians? Crit Care Med 36:1955–1956. doi:10.1097/CCM.0b013e31817616c0

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors thank all participants for their contribution to this study. This study was supported by grants from the National Science Foundation of China (81402993), the Hunan Provincial Natural Science Foundation of China (13JJ5010), and the Hunan special fund for science and technology development program (2013WK3022).

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  1. Furong Zeng and Qianyun Xu contributed equally to this work

Authors and Affiliations

  1. Department of Rheumatology and Immunology, Xiangya Hospital, Institute of Rheumatology and Immunology, Central South University, Changsha, Hunan, 410008, China

    Furong Zeng, Qianyun Xu, Di Liu, Hui Luo, Ya-ou Zhou, Wangbin Ning, Jiangyan Chen, Yisha Li & Xiaoxia Zuo

  2. Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China

    Huali Zhang

  3. Mental Heath Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China

    Haihong Liu

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  1. Furong Zeng
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Correspondence to Yisha Li.

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Zeng, F., Xu, Q., Liu, D. et al. Relatives’ quality of life and psychological disturbance: a new concern of SLE management. Clin Rheumatol 37, 67–73 (2018). https://doi.org/10.1007/s10067-017-3743-1

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  • DOI: https://doi.org/10.1007/s10067-017-3743-1

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