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Association of serum uric acid and risk of hypertension in adults: a prospective study of Kailuan Corporation cohort

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Abstract

Whether hyperuricemia is an independent risk factor for hypertension in adults is still under debate. To determine the association between serum uric acid and risk of hypertension in the Chinese population, we conducted a prospective study using the “Kailuan Corporation cohort.” A total of 39,233 adult subjects with available data on serum uric acid were enrolled from 2006 to 2007. Subjects with established hypertension were excluded and were then grouped based on the gender and baseline quartile serum uric acid into F1–4 for women and M1–4 for men with F1 and M1 being the lowest quartiles. Incidence of newly described primary hypertension was reevaluated in 2010–2011. The median (interquantile range) baseline uric acid (UA) was 290 (243–344) μmol/L in men and 230 (194–274) μmol/L in women. During a 4-year follow-up period, 12,844 subjects (31.31 %) were newly diagnosed with hypertension. The incidence of hypertension was 14.36, 16.57, 19.06, and 22.35 % in F1 to F4 and 33.64, 33.97, 36.54, and 40.74 % in M1 to M4, respectively. Multiple logistic regression analysis showed that the odds ratios (ORs) of incident hypertension were 1.17 [95 % confidence interval (CI) 1.00–1.37, P = 0.055], 1.24 (95 % CI 1.06–1.45, P = 0.009), and 1.20 (95 % CI 1.02–1.41, P = 0.027) in F2 to F4 compared to the F1 and 0.98 (95 % CI 0.91–1.05, P = 0.534), 1.05 (95 % CI 0.98–1.13, P = 0.190), and 1.13 (95 % CI 1.05–1.22, P = 0.002) in M2 to M4 compared to the M1. Elevated level of serum uric acid is associated with an increased risk of hypertension in adults.

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Abbreviations

BMI:

Body mass index

BP:

Blood pressure

CRP:

C-reactive protein

DBP:

Diastolic blood pressure

eGRF:

Estimated glomerular filtration rate

FBG:

Fasting blood glucose

HDL:

High-density lipoprotein

MI:

Myocardial infarction

LDL:

Low-density lipoprotein

SBP:

Systolic blood pressure

SUA:

Serum uric acid

TC:

Total cholesterol

TG:

Triglyceride

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Acknowledgements

We are very grateful to all participants for their cooperation and for giving consent to participate in this study. We thank all the staff for their dedication.

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Authors and Affiliations

  1. Department of Rheumatology and Immunology, Hebei United University Kailuan Hospital, Tangshan, 063000, China

    Liu-fu Cui, Hui-jing Shi, Rong Shu, Ping Yu, Jian Wang, Hai-cheng Song, Wen-hao Yang, Jie-rui Wang & Yi-xuan Han

  2. Department of Cardiology, Hebei United University Kailuan Hospital, Tangshan, 063000, China

    Shou-ling Wu

  3. Department of Rheumatology and Immunology, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China

    Na Liu, Guan-ying Wang & Rong Mu

  4. Department of Epidemiology & Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, 100191, China

    Bin Zhou

  5. Department of Rheumatology, Hospital for Special Surgery, New York, NY, 10021, USA

    Kai Sun

Authors
  1. Liu-fu Cui
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  2. Hui-jing Shi
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  8. Kai Sun
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  10. Jian Wang
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  14. Yi-xuan Han
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  15. Rong Mu
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Corresponding author

Correspondence to Rong Mu.

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Funding

This study was supported by the National High Technology Research and Development Program of China (973 Program, No. 2012CB517700) and National Natural Science Foundation of China (No. 31170840 and No. 81471536).

Additional information

Liu-fu Cui and Hui-jing Shi contributed equally to this study.

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Cui, Lf., Shi, Hj., Wu, Sl. et al. Association of serum uric acid and risk of hypertension in adults: a prospective study of Kailuan Corporation cohort. Clin Rheumatol 36, 1103–1110 (2017). https://doi.org/10.1007/s10067-017-3548-2

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  • DOI: https://doi.org/10.1007/s10067-017-3548-2

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