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A double-blind randomized comparative study of triamcinolone hexacetonide and dexamethasone intra-articular injection for the treatment of knee joint arthritis in rheumatoid arthritis

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Abstract

Intra-articular glucocorticoid (GC) injection has been used for more than half a century in the treatment of refractory synovitis in patients with rheumatoid arthritis (RA). There are limited data about the efficacy of intra-articular injection of various preparations of GCs on inflamed joint. The aim of this study was to compare the efficacy and side effects of intra-articular injection of dexamethasone (DEX) and triamcinolone hexacetonide (TH) in the treatment of knee joint arthritis in RA. In a double-blind randomized clinical trial, 70 patients with RA and knee joint arthritis were recruited to the study. Swelled knee joints were injected with 40 mg TH or 8 mg DEX randomly. The primary outcome measures were reduction of knee joint swelling and pain 1 and 3 weeks after joint injection. The secondary outcome measures were relapse of knee arthritis at 2, 4, and 6 months after injection and side effects of intra-articular injection. Difference in the knee circumferences between DEX and TH groups at weeks 1 and 3 was not significant. The average times of pain reduction after injection were 3.4 ± 2.3 and 2.3 ± 1.8 days in TH and DEX, respectively. There were no differences of knee pain between the two groups. Relapse of knee arthritis was occurred in two (6.7 %) and three (9.4 %) patients in the DEX and TH groups, respectively. Intra-articular injection of DEX like TH causes rapid and long-term reduction of knee pain and swelling in patients with RA and is safe.

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Acknowledgments

This study was supported by the research funds of Tabriz University of Medical Sciences. The authors extend their gratitude to Dr. L. Khabbazi for editing this manuscript.

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Authors and Affiliations

  1. Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Mehrzad Hajialilo, Leyla Valaee, Sousan Kolahi, Naderh Rashtchizadeh, Ida Malekmahdavi & Alireza Khabbazi

  2. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Amir Ghorbanihaghjo

  3. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Maryam Bannazadeh Amirkhiz

Authors
  1. Mehrzad Hajialilo
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  2. Amir Ghorbanihaghjo
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  3. Leyla Valaee
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  4. Sousan Kolahi
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  5. Naderh Rashtchizadeh
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  6. Maryam Bannazadeh Amirkhiz
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  7. Ida Malekmahdavi
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  8. Alireza Khabbazi
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Corresponding author

Correspondence to Alireza Khabbazi.

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All of the authors declare that this study was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All persons gave informed consent prior to participation in this study.

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No financial interests related to the material in the manuscript.

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Hajialilo, M., Ghorbanihaghjo, A., Valaee, L. et al. A double-blind randomized comparative study of triamcinolone hexacetonide and dexamethasone intra-articular injection for the treatment of knee joint arthritis in rheumatoid arthritis. Clin Rheumatol 35, 2887–2891 (2016). https://doi.org/10.1007/s10067-016-3397-4

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  • DOI: https://doi.org/10.1007/s10067-016-3397-4

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