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Comorbid conditions are associated with healthcare utilization, medical charges and mortality of patients with rheumatoid arthritis

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Abstract

This study aims to examine the associations between comorbid conditions and healthcare utilization, medical charges, or mortality of patients with rheumatoid arthritis (RA). Nebraska state emergency department (ED) discharge, hospital discharge, and death certificate data from 2007 to 2012 were used to study the comorbid conditions of patients with RA. RA was defined using the standard International Classification of Diseases (ICD-9-CM 714 or ICD-10-CM M05, M06, and M08). There were more comorbid conditions in patients with RA than in patients without RA. Comorbid conditions were majorly related to healthcare utilization and mortality of patients with RA. In addition to injury, fracture, sprains, and strains, symptoms of cardiovascular and digestive systems, respiratory infection, and chronic obstructive pulmonary disease (COPD) were common comorbid conditions for ED visits. In addition to joint replacement and fracture, infections, COPD and cardiovascular comorbidities were common comorbid conditions for hospitalizations. Cardiovascular, cerebrovascular, and respiratory comorbidities, dementia, malignant neoplasm, and diabetes mellitus were common comorbid conditions for deaths of patients with RA. In addition, the numbers of comorbid conditions were significantly associated with the length of hospital stay and hospital charges for patients with RA. The findings in this study indicated that comorbid conditions are associated with healthcare utilization, medical charges, and mortality of patients with RA.

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References

  1. Körmendy D, Hoff H, Hoff P et al (2013) Impact of the CTLA-4/CD28 axis on the processes of joint inflammation in rheumatoid arthritis. Arthritis Rheum 65:81–87

    Article  PubMed  Google Scholar 

  2. Cross M, Smith E, Hoy D et al (2014) The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis 73:1316–1322

    Article  PubMed  Google Scholar 

  3. Eriksson JK, Johansson K, Askling J et al (2015) Costs for hospital care, drugs and lost work days in incident and prevalent rheumatoid arthritis: how large, and how are they distributed? Ann Rheum Dis 74:648–654

    Article  PubMed  Google Scholar 

  4. Eberhardt K, Larsson BM, Nived K et al (2007) Work disability in rheumatoid arthritis—development over 15 years and evaluation of predictive factors over time. J Rheumatol 34:481–487

    PubMed  Google Scholar 

  5. Gonzalez A, Maradit Kremers H, Crowson CS et al (2007) The widening mortality gap between rheumatoid arthritis patients and the general population. Arthritis Rheum 56:3583–3587

    Article  PubMed  Google Scholar 

  6. Dadoun S, Zeboulon-Ktorza N, Combescure C et al (2013) Mortality in rheumatoid arthritis over the last fifty years: systematic review and meta-analysis. Joint Bone Spine 80:29–33

    Article  PubMed  Google Scholar 

  7. Widdifield J, Bernatsky S, Paterson JM et al (2015) Trends in excess mortality among patients with rheumatoid arthritis in Ontario, Canada. Arthritis Care Res 67:1047–1053

    Article  Google Scholar 

  8. Maradit-Kremers H, Nicola PJ, Crowson CS et al (2005) Cardiovascular death in rheumatoid arthritis: a population-based study. Arthritis Rheum 52:722–732

    Article  PubMed  Google Scholar 

  9. Smith EM, Foster HE, Beresford MW (2013) Adding to complexity: comorbidity in paediatric rheumatic disease. Rheumatology (Oxford) 52:22–33

    Article  Google Scholar 

  10. Turesson C, Matteson EL (2013) Malignancy as a comorbidity in rheumatic diseases. Rheumatology (Oxford) 52:5–14

    Article  Google Scholar 

  11. Nurmohamed MT, Heslinga M, Kitas GD (2015) Cardiovascular comorbidity in rheumatic diseases. Nat Rev Rheumatol 11:693–704

    Article  CAS  PubMed  Google Scholar 

  12. Jacobsson LT, Knowler WC, Pillemer S et al (1993) Rheumatoid arthritis and mortality. A longitudinal study in Pima Indians. Arthritis Rheum 36:1045–1053

    Article  CAS  PubMed  Google Scholar 

  13. Osiri M, Sattayasomboon Y (2013) Prevalence and out-patient medical costs of comorbid conditions in patients with rheumatoid arthritis. Joint Bone Spine 80:608–612

    Article  PubMed  Google Scholar 

  14. Joyce AT, Smith P, Khandker R et al (2009) Hidden cost of rheumatoid arthritis (RA): estimating cost of comorbid cardiovascular disease and depression among patients with RA. J Rheumatol 36:743–752

    Article  PubMed  Google Scholar 

  15. Bureau of labor statistics. Producer Price Index Archived News Releases. Available at: http://www.bls.gov/schedule/archives/ppi_nr.html

  16. Blough DK, Ramsey SD (2000) Using generalized linear models to assess medical care costs. Health Serv Outcome Res Methodol 1:185–202

    Article  Google Scholar 

  17. Kroot EJ, van Gestel AM, Swinkels HL et al (2001) Chronic comorbidity in patients with early rheumatoid arthritis: a descriptive study. J Rheumatol 28:1511–1517

    CAS  PubMed  Google Scholar 

  18. Stanmore EK, Oldham J, Skelton DA et al (2013) Risk factors for falls in adults with rheumatoid arthritis: a prospective study. Arthritis Care Res 65:1251–1258

    Article  Google Scholar 

  19. Stanmore EK, Oldham J, Skelton DA et al (2013) Fall incidence and outcomes of falls in a prospective study of adults with rheumatoid arthritis. Arthritis Care Res 65:737–744

    Article  Google Scholar 

  20. Nelissen RG (2003) The impact of total joint replacement in rheumatoid arthritis. Best Pract Res Clin Rheumatol 17:831–846

    Article  PubMed  Google Scholar 

  21. Jain A, Stein BE, Skolasky RL et al (2012) Total joint arthroplasty in patients with rheumatoid arthritis: a United States experience from 1992 through 2005. J Arthroplasty 27:881–888

    Article  PubMed  Google Scholar 

  22. Yasui T, Nishino J, Shoda N et al (2015) Prevalence of total knee arthroplasty and its predictive factors in Japanese patients with rheumatoid arthritis: analysis using the NinJa cohort. Mod Rheumatol 15:1–4

    Google Scholar 

  23. Dougados M, Soubrier M, Antunez A et al (2014) Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA). Ann Rheum Dis 73:62–68

    Article  PubMed  PubMed Central  Google Scholar 

  24. Doran MF, Crowson CS, Pond GR et al (2002) Frequency of infection in patients with rheumatoid arthritis compared with controls: a population-based study. Arthritis Rheum 46:2287–2293

    Article  PubMed  Google Scholar 

  25. Listing J, Gerhold K, Zink A (2013) The risk of infections associated with rheumatoid arthritis, with its comorbidity and treatment. Rheumatology (Oxford) 52:53–61

    Article  CAS  Google Scholar 

  26. Germano V, Cattaruzza MS, Osborn J et al (2014) Infection risk in rheumatoid arthritis and spondyloarthropathy patients under treatment with DMARDs, corticosteroids and TNF-α antagonists. J Transl Med 12:77

    Article  PubMed  PubMed Central  Google Scholar 

  27. Choy E, Ganeshalingam K, Semb AG et al (2014) Cardiovascular risk in rheumatoid arthritis: recent advances in the understanding of the pivotal role of inflammation, risk predictors and the impact of treatment. Rheumatology (Oxford) 53:2143–2154

    Article  Google Scholar 

  28. Solomon DH, Avorn J, Katz JN et al (2006) Immunosuppressive medications and hospitalization for cardiovascular events in patients with rheumatoid arthritis. Arthritis Rheum 54:3790–3798

    Article  CAS  PubMed  Google Scholar 

  29. Meune C, Touzé E, Trinquart L et al (2009) Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta-analysis of cohort studies. Rheumatology (Oxford) 48:1309–1313

    Article  Google Scholar 

  30. Rennard SI (1999) Inflammation and repair processes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160:S12–S16

    Article  CAS  PubMed  Google Scholar 

  31. Andreakos E (2004) Common and uncommon features of rheumatoid arthritis and chronic obstructive pulmonary disease: clues to a future therapy. Curr Drug Targets Immune Endocr Metabol Disord 4:85–92

    Article  CAS  PubMed  Google Scholar 

  32. Shen TC, Lin CL, Chen CH et al (2014) Increased risk of chronic obstructive pulmonary disease in patients with rheumatoid arthritis: a population-based cohort study. QJM 107:537–543

    Article  PubMed  Google Scholar 

  33. Bieber V, Cohen AD, Freud T et al (2013) Autoimmune smoke and fire—coexisting rheumatoid arthritis and chronic obstructive pulmonary disease: a cross-sectional analysis. Immunol Res 56:261–266

    Article  PubMed  Google Scholar 

  34. Lanas A, Boers M, Nuevo J (2015) Gastrointestinal events in at-risk patients starting non-steroidal anti-inflammatory drugs (NSAIDs) for rheumatic diseases: the EVIDENCE study of European routine practice. Ann Rheum Dis 74:675–681

    Article  CAS  PubMed  Google Scholar 

  35. Nakajima A, Inoue E, Tanaka E et al (2010) Mortality and cause of death in Japanese patients with rheumatoid arthritis based on a large observational cohort, IORRA. Scand J Rheumatol 39:360–367

    Article  CAS  PubMed  Google Scholar 

  36. Barnabe C, Thanh NX, Ohinmaa A et al (2013) Healthcare service utilisation costs are reduced when rheumatoid arthritis patients achieve sustained remission. Ann Rheum Dis 72:1664–1668

    Article  PubMed  Google Scholar 

  37. Hooft A, Ronda J, Schaeffer P et al (2013) Identification of physical abuse cases in hospitalized children: accuracy of International Classification of Diseases codes. J Pediatr 162:80–85

    Article  PubMed  Google Scholar 

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Correspondence to Guang-Ming Han or Xiao-Feng Han.

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Significance and innovations

This study showed that there are more comorbid conditions in patients with RA than in patients without RA.

This study provided that comorbid conditions are majorly related to healthcare utilization and mortality of patients with RA.

The results suggested that the numbers of comorbid conditions are significantly associated with the length of hospital stay for patients with RA.

The results suggested that the numbers of comorbid conditions are significantly associated with hospital charges for patients with RA.

Guang-Ming Han and Xiao-Feng Han contributed equally to this work.

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Han, GM., Han, XF. Comorbid conditions are associated with healthcare utilization, medical charges and mortality of patients with rheumatoid arthritis. Clin Rheumatol 35, 1483–1492 (2016). https://doi.org/10.1007/s10067-016-3277-y

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  • DOI: https://doi.org/10.1007/s10067-016-3277-y

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