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Anti-nuclear antibodies as predictor of outcome in a multi-center cohort of Italian children and adolescents with Raynaud’s phenomenon

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Abstract

A retrospective multi-center data collection of clinical, laboratory, and treatment characteristics of 94 Caucasian children and adolescents with Raynaud’s phenomenon (RP) started at a mean age of 12.8 ± 5 years, with variable involvement of hands, feet, and face, was performed for a period of 3 years. Collected data included nailfold videocapillaroscopy (NVC), lung function tests, and different laboratory tests finalized to characterize an eventual connective tissue disease (CTD), disclosed by RP itself. Twelve patients presented an early-scleroderma pattern at NVC, 1 a late-scleroderma pattern, and 58 a nonspecific pattern. Laboratory data results showed the positivity of anti-nuclear antibodies (ANA) in 29 % of patients. After this 3-year period of observation, 8 patients had developed a CTD. Our data examined by multivariate analysis, though limited to a multi-center cohort of pediatric patients with RP, strongly suggest that ANA positivity is a significant predictor of progression of RP towards a CTD.

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Conflict of interest

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Authors and Affiliations

  1. Department of Experimental and Clinical Medicine and Department of Biomedicine, Division of Rheumatology AOUC & Transition Clinic, University of Florence, Viale Pieraccini 18, 50139, Florence, Italy

    Fernanda Falcini & Marco Matucci Cerinic

  2. Institute of Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy

    Donato Rigante & Carmela G. L. Raffaele

  3. Department of Internal Medicine, Università Cattolica Sacro Cuore, Rome, Italy

    Marcello Candelli

  4. Department of Pediatrics, University of Padua, Padua, Italy

    Giorgia Martini

  5. Department of Pediatrics, University of Milan, Milan, Italy

    Fabrizia Corona & Antonella Petaccia

  6. Department of Pediatrics, A. Perrino Hospital, Brindisi, Italy

    Francesco La Torre

Authors
  1. Fernanda Falcini
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  2. Donato Rigante
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  3. Marcello Candelli
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  4. Giorgia Martini
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  5. Fabrizia Corona
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  6. Antonella Petaccia
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  7. Francesco La Torre
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  8. Carmela G. L. Raffaele
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  9. Marco Matucci Cerinic
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Corresponding author

Correspondence to Fernanda Falcini.

Additional information

Fernanda Falcini and Donato Rigante equally contributed to this brief report.

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Falcini, F., Rigante, D., Candelli, M. et al. Anti-nuclear antibodies as predictor of outcome in a multi-center cohort of Italian children and adolescents with Raynaud’s phenomenon. Clin Rheumatol 34, 167–169 (2015). https://doi.org/10.1007/s10067-014-2833-6

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  • DOI: https://doi.org/10.1007/s10067-014-2833-6

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