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Molecules and Cells

, Volume 36, Issue 6, pp 477-484

Recent advances in nanobiotechnology and high-throughput molecular techniques for systems biomedicine

  • Eung-Sam KimAffiliated withDepartment of Bioengineering, University of WashingtonDepartment of Medical System Engineering, Gwangju Institute of Science and Technology
  • , Eun Hyun AhnAffiliated withDepartment of Pathology, School of Medicine, University of WashingtonInstitute of Stem Cell and Regenerative Medicine, University of Washington
  • , Euiheon ChungAffiliated withDepartment of Medical System Engineering, Gwangju Institute of Science and TechnologySchool of Mechatronics, Gwangju Institute of Science and Technology
  • , Deok-Ho KimAffiliated withDepartment of Bioengineering, University of WashingtonInstitute of Stem Cell and Regenerative Medicine, University of WashingtonCenter for Cardiovascular Biology, University of Washington Email author 

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Abstract

Nanotechnology-based tools are beginning to emerge as promising platforms for quantitative high-throughput analysis of live cells and tissues. Despite unprecedented progress made over the last decade, a challenge still lies in integrating emerging nanotechnology-based tools into macroscopic biomedical apparatuses for practical purposes in biomedical sciences. In this review, we discuss the recent advances and limitations in the analysis and control of mechanical, biochemical, fluidic, and optical interactions in the interface areas of nanotechnologybased materials and living cells in both in vitro and in vivo settings.

Keywords

bioimaging microarray microfluidics nanomaterials nanotechnology next generation DNA sequencing quantum dot