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Acute gonadotropin response to the gonadotropin releasing hormone agonist (decapeptyl) in girls with pubertal pathology

  • Original Research
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Annals of Diagnostic Paediatric Pathology

Abstract

The aim of the study was to assess the effect of a single injection of the GnRH agonist decapeptyl on gonadotropin secretion in girls with different pubertal disorders. The test was performed in two groups of girls with premature thelarche (younger and older than 2 years of age), girls with premature adrenarche and postmenarcheal girls with policystic ovaries. The GnRH agonist decapeptyl stimulated gonadotropins secretion in pre- and postmenarcheal girls. The responsiveness of LH was increased significantly in puberty. FSH response was exaggerated in the girls with premature thelarche before the age of 2, but in older premenarcheal girls with the same disorder it was not different than in girls with premature adrenarche. It is concluded that a single dose of the GnRH agonist decapeptyl is a safe and efficacious test for assessment of the function of the pituitary gland in pre-and postmenarcheal girls.

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Authors and Affiliations

  1. ]Department of Pathophysiology Silesian School of Medicine, Medyków 18, PL-40752, Katowice, Poland

    Ewa Małecka-Tendera

  2. Department of Pediatric Endocrinology and Diabetology, Silesian School of Medicine, Katowice, Poland

    Aleksandra Januszek-Trzciąkowska & Małgorzata Muchacka-Bianga

  3. Department of Physiology, Silesian School of Medicine, Katowice, Poland

    Joanna Lewin-Kowalik

Authors
  1. Ewa Małecka-Tendera
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  2. Aleksandra Januszek-Trzciąkowska
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  3. Małgorzata Muchacka-Bianga
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  4. Joanna Lewin-Kowalik
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Małecka-Tendera, E., Januszek-Trzciąkowska, A., Muchacka-Bianga, M. et al. Acute gonadotropin response to the gonadotropin releasing hormone agonist (decapeptyl) in girls with pubertal pathology. Ann Diagn Paed Pathol 2, 9–12 (1998). https://doi.org/10.1007/s100570050002

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  • DOI: https://doi.org/10.1007/s100570050002

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