Abstract
The sessile serrated adenoma/polyp (SSA/P) has been thought as the relatively new precursor for the colorectal cancer. In the current review, the well-known pathological features including the histological definition of the SSA/P are described using the previous reports. Although the SSA/P is thought one of pre-cancerous lesions of the colorectal carcinoma, the decisive or documentary lesion like “carcinoma in adenoma” is very rare. In this review, the strict case of the carcinoma derived from the SSA/P is demonstrated using our cases. Although the genetic investigations of the SSA/P have shown the new pathway of colorectal carcinogenesis and these concepts are thought to be almost right, the verification for them should be performed using “the carcinoma in SSA/P” like the present case.
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Snover DC, Ahnen DJ, Odze RD (2010) Serrated polyps of the colon and rectum and serrated polyposis. In: Bosman FT, Carneio F, Hruban RH, Theise N (eds) WHO classification of tumours. Pathology and genetics. Tumours of digestive system, 4th edn. International Agency for Research on Cancer, Lyon, pp 160–165
Hamatani S, Wada R, Tsujimoto S, Yanagita M, Mitsuda A, Hasegawa C, Aruki H, Yamashita S (1998) Nuclear morphometric study on colorectal polyps with epithelial serrated proliferation. J Jpn Soc Coloproctol 51:555–566 (in Japanese with English abstract)
Hamatani S, Wada R, Tsujimoto S, Yanagita M, Mitsuda A, Hasegawa C, Kuwahata N, Yokouchi Y, Miura M (2001) Histomorphometric characteristics and cellular kinetics of colorectal polyps with epithelial serrated proliferation adjacent to carcinoma. Oncol Rep 8:49–55
Hamatani S, Wada R, Morita A, Hasegawa C, Mitsuda A, Hatori T, Nonaka H, Takahashi K, Gomi S, Shibuya K (2005) Cellular kinetics and K-ras codon 12 mutations according to histomorphometric type of colorectal polyps with epithelial serrated proliferation. Oncol Rep 14:121–127
Wada R, Abe H, Itakura M, Sato K, Matsukuma S, Kuwabara N, Suda K (1996) Pathological study on flat hyperplastic polyp of large bowel. J Jpn Res Soc Gastroenterol Carcinog 8:173–178 (in Japanese)
Ajioka Y, Watanabe H, Jass JR, Yokota Y, Kobayashi M, Nishikura K (1998) Infrequent K-ras codon 12 mutation in serrated adenomas of human colorectum. Gut 42:680–684
Tonooka T, Sano Y, Fujii T, Kato S, Yoshino T, Fu KI, Hironaka S, Ochiai A, Yoshida S (2002) Adenocarcinoma in solitary large hyperplastic polyp diagnosed by magnifying colonoscope. Dis Colon Rectum 45:1407–1411
Sumner HW, Wasserman NF, McClain CJ (1981) Giant hyperplastic polyposis of the colon. Dig Dis Sci 26:85–89
Longacre TA, Fenoglio-Preiser CM (1990) Mixed hyperplastic adenomatous polyps/serrated adenomas: a distinct from of colorectal neoplasia. Am J Surg Pathol 14:524–537
Hayashi T, Yatani R, Apostol J, Stemmermann GN (1974) Pathogenesis of hyperplastic polyps of the colon: a hypothesis based on ultrastructure and in vitro cell kinetics. Gastroenterology 66:347–356
Jass JR, Young J, Leggett BA (2000) Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum. Histopathology 37:295–301
Jass JR (2001) Serrated route to colorectal cancer: back street or super highway? J Pathol 193:283–285
Jass JR (2003) Hyperplastic-like polyps as precursors of microsatellite-unstable colorectal cancer. Am J Clin Pathol 119:773–775
Torlakovic E, Skovlund E, Snover DC, Torlakovic G, Nesland JM (2003) Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol 27:65–81
Torlakovic EE, Gomez JD, Driman DK, Parfitt JR, Wang C, Benerjee T, Snover DC (2008) Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA). Am J Surg Pathol 32:21–29
Yao T, Sugai T, Iwashita A, Fujimori T, Kushima R, Nobuki M, Mitomi H, Ajioka Y, Konishi F (2011) Histopathological characteristics and diagnostic criteria of SSA/P. Project research “potential of cancerization of colorectal serrated lesions” of Japanese Society for Cancer of the Colon and Rectum. Stomach Intest 46:442–448 (in Japanese with English abstract)
Kashida H, Ikehara N, Hamatani S, Kudo SE, Kudo M (2011) Endoscopic characteristics of colorectal serrated lesions. Hepatogastroenterology 58:1163–1167
Burnett-Hartman AN, Newcomb PA, Phipps AI, Passarelli MN, Grady WM, Upton MP, Zhu LC, Potter JD (2011) Colorectal endoscopy, advanced adenomas, and sessile serrated polyps: implications for proximal colon cancer. Am J Gastroenterol 107:1213–1219
Ishiguro S, Nomoto M, Obinata N, Oishi Y, Sato Y, Nakatsu S, Suzuki M, Ikeda Y, Maehata T, Kimura T, Watanabe Y, Nakajima T, Yamano HO, Yasuda H, Ito F (2012) Evaluation of magnifying colonoscopy in the diagnosis of serrated polyps. World J Gastroenterol 18:4308–4316
Rosty C, Hewett DG, Brown IS, Leggett BA, Whitehall VLJ (2013) Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management. J Gastroenterol 48:287–302
Kimura T, Yamamoto E, Yamano H, Suzuki H, Kamimae S, Nojima M, Sawada T, Ashida M, Yoshikawa K, Takagi R, Kato R, Harada T, Suzuki R, Maruyama R, Kai M, Imai K, Shinomura Y, Sugai T, Toyota M (2011) A novel pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma. Am J Gastroenterol 107:460–469
Dhir M, Yachida S, Neste LV, Glockner SC, Jeschke J, Pappou EP, Montgomery EA, Herman JG, Baylin SB, Donahue CLI, Ahuja N (2011) Sessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract. Int J Cancer 129:1889–1898
Fujita K, Yamamoto H, Matsumoto T, Hirahashi M, Gushima M, Kishimoto J, Nishiyama K, Taguchi T, Yao T, Oda Y (2011) Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular study. Am J Surg Pathol 35:295–304
Mohammadi M, Kristensen MH, Nielsen HJ, Bonde JH, Holck S (2012) Qualities of sessile serrated adenoma/polyp/lesion and its borderline variant in the context of synchronous colorectal carcinoma. J Clin Pathol 65:924–927
Hirano H, Ajioka Y, Watanabe H, Baba Y, Tozawa E, Nishikura K, Mukai G, Honma T, Aoyagi Y (2004) Bidirectional gastric differentiation in cellular mucin phenotype (foveolar and pyloric) in serrated adenoma and hyperplastic polyp of colorectum. Pathol Int 54:401–407
Gibson JA, Hahn HP, Shahsafaei A, Odze RD (2011) MUC expression in hyperplastic and serrated colonic polyps: lack of specificity of MUC6. Am J Surg Pathol 35:742–749
Fujimori Y, Fujimori T, Imura J, Sugai T, Yao T, Wada R, Ajioka Y, Ohkura Y (2012) An assessment of the diagnostic criteria for sessile serrated adenoma/polyps: SSA/Ps using processing software analysis for Ki67 immunohistochemistry. Diagn Pathol 7:59
Jass JR (2005) Serrated adenoma of the colorectum and DNA-methylator phenotype. Nat Clin Pract Oncol 2:398–405
O’Brien MJ (2007) Hyperplastic and serrated polyps of the colorectum. Gastroenterol Clin N Am 36:947–968
Kim KM, Lee EJ, Ha S, Kang SY, Jang KT, Park CK, Kim JY, Kim YH, Chang DY, Odze RD (2011) Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea. Am J Surg Pathol 35:1274–1286
Kim MJ, Lee EJ, Chu SM, Jang SJ, Kim CH, Seo JP, Kim do S, Lee DH, Youk EG (2013) Pedunculated serrated polyp with histological features of sessile serrated adenoma: a clinicopathological and molecular study. Am J Surg Pathol 37:1039–1043
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Wada, R., Morimoto, T. & Inayoshi, T. Pathological features of the sessile serrated adenoma/polyp with special references of its carcinogenesis. Med Mol Morphol 47, 123–129 (2014). https://doi.org/10.1007/s00795-014-0075-y
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DOI: https://doi.org/10.1007/s00795-014-0075-y