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Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjögren’s syndrome

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Abstract

Objectives

The purpose of this study was to evaluate efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) containing pastes among individuals with Sjögren’s syndrome (SS).

Materials and methods

Thirty patients were randomised into three groups: CPP-ACP, CPP-ACFP, and 0.05 % NaF to be used two times a day during a 28-day experimental period. Saliva was analysed for flow rate, pH, buffering capacity and mineral concentrations. Dental plaque was examined for pH. Following the formation of artificial carious lesion, participants wore enamel slabs for an in situ remineralisation study. Remineralisation potential was examined using scanning electron microscope (SEM) and energy dispersive spectroscopic (EDS) technique. SE microphotographs were subsequently analysed for area, diameter, perimeter, roundness and the number of enamel defects and percentage of tooth surface affected by defects.

Results

At the end of the experimental period, a slight increase of salivary pH could have been observed. No differences in mineral composition of saliva were noted. The use of CPP-ACP and CPP-ACFP contributed to a significant rise of plaque pH. Image analysis revealed excessive reduction of defects’ dimensions in the three experimental groups, and a decrease of the number of enamel defects in the CPP-ACP and CPP-ACFP groups. The EDS analysis did not show differences in Ca/P, Ca/O and P/O ratios in any of the treatment groups.

Conclusion

CPP-ACP and CPP-ACFP hold promise as remineralising agents for patients with SS.

Clinical relevance

Pastes containing CPP-ACP/CPP-ACFP show enhanced remineralisation potential compared with NaF mouthrinse in patients with SS.

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Conflict of interests

The authors declare that they have no competing interests. GC Int. (Tokyo, Japan) and Curaden International AG (Kriens, Switzerland) provided the materials, but no funding for this study, and did not have role in the study design, data collection and analysis, decision to publish or preparation of the manuscript.

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Authors and Affiliations

  1. Department of Paediatric and Preventive Dentistry, Faculty of Dental Medicine, University of Belgrade, Dr Subotica 11, 11000, Belgrade, Serbia

    Tamara Peric & Dejan Markovic

  2. Department of Paediatric and Preventive Dentistry, Dentistry Clinic of Vojvodina, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 12, Novi Sad, Serbia

    Bojan Petrovic

  3. Department of Materials Science and Engineering, Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, Serbia

    Vesna Radojevic & Radmila Jancic Heinemann

  4. Department of Biochemistry, Faculty of Dental Medicine, University of Belgrade, Dr Subotica 1, Belgrade, Serbia

    Tatjana Todorovic & Biljana Andjelski Radicevic

  5. Institute for Rheumatology, Resavska 69, Belgrade, Serbia

    Gordana Susic

  6. Faculty of Medicine, University of Belgrade, Dr Subotica 8, Belgrade, Serbia

    Aleksandra Peric Popadic & Vesna Tomic Spiric

  7. Clinic of Allergology and Immunology, Clinical Center of Serbia, Koste Todorovića 2, Belgrade, Serbia

    Aleksandra Peric Popadic & Vesna Tomic Spiric

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  1. Tamara Peric
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  2. Dejan Markovic
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  7. Radmila Jancic Heinemann
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Correspondence to Tamara Peric.

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Peric, T., Markovic, D., Petrovic, B. et al. Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjögren’s syndrome. Clin Oral Invest 19, 2153–2165 (2015). https://doi.org/10.1007/s00784-015-1444-1

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  • DOI: https://doi.org/10.1007/s00784-015-1444-1

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