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Some nontoxic metal-based drugs for selected prevalent tropical pathogenic diseases

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Abstract

Metal coordination of bioorganic compounds from both natural and synthetic products is not only gaining recognition in drug design and medicinal inorganic chemistry research, also they are being considered in the improvement of the bioactivity of drugs. What is done in this paper is a review of recent advances in the study of coordination-driven drug delivery, i.e., metal-based drugs (MBDs). The role of some late first row transition metal ions namely Fe, Cu and Zn in the biological activities of metallodrugs such as antimalarials and antimicrobials are highlighted. It was revealed that the interaction between these bio-essential transition metal ions and the organic drugs could enhance the diagnostic and therapeutic potentials of such formed drugs. This is because such interactions were proved to have improved the stability, bioavailability and cell delivery functions of the metallodrugs. Emphasizing on the challenge of metal ions toxicity, the researchers concluded on the need for the development of MBDs to combat drug resistant parasites without causing injury to normal cells. This would be of significance in addressing the concern World Health Organisation of ameliorating the increasing mortality rate in developing countries.

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Abbreviations

MBDs:

Metal-based drugs

CQ:

Chloroquine

CQDP:

Chloroquine diphosphate

QN:

Quinine

ACT:

Amoxicilin trihydrate

MAMDs:

Metal antimalarial drugs

MAMcDs:

Metal antimicrobial drugs

ATP:

Adenosine triphosphate

mRNA:

Messenger ribonucleic acid

tRNA:

Transfer ribonucleic acid

rRNA:

Ribosomal ribonucleic acid

DNA:

Deoxyribonucleic acid

DDS:

Drug delivery system

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Acknowledgements

Professor, Anife Ahmedova of Laboratory of Biocoordination and Bioanalytical Chemistry, Department of Analytical Chemistry, Sofia University, 1, J. Bourchier Blvd., 1164 Sofia, Bulgaria is appreciated for her contribution and provision of useful materials for this article. SAA is grateful to Matsumae International Foundation (MIF), Japan and Japan Society for the Promotion of Science (JSPS) for his postdoctoral fellowships support (P13340) and the Federal University of Agriculture, Abeokuta. JAO appreciates World Bank Supported Science and Technology Education Post-Basic Project (STEP- B) and University of Ilorin Senate Research Grant Committee.

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Authors and Affiliations

  1. Department of Chemistry, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Kumamoto, 860-8555, Japan

    Saliu A. Amolegbe

  2. Department of Chemistry, Federal University of Agriculture, PMB 2240, Abeokuta, Ogun State, Nigeria

    Caroline A. Akinremi & Sheriff Adewuyi

  3. Department of Chemistry, University of Ilorin, PMB 1515, Ilorin, Kwara State, Nigeria

    Amudat Lawal, Mercy O. Bamigboye & Joshua A. Obaleye

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  1. Saliu A. Amolegbe
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  2. Caroline A. Akinremi
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  3. Sheriff Adewuyi
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  4. Amudat Lawal
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  5. Mercy O. Bamigboye
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  6. Joshua A. Obaleye
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Correspondence to Joshua A. Obaleye.

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Amolegbe, S.A., Akinremi, C.A., Adewuyi, S. et al. Some nontoxic metal-based drugs for selected prevalent tropical pathogenic diseases. J Biol Inorg Chem 22, 1–18 (2017). https://doi.org/10.1007/s00775-016-1421-4

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