Skip to main content

Advertisement

SpringerLink
Log in

The association between vitamin D and parathyroid hormone and bone mineral density: the Dong-gu Study

  • Original Article
  • Published:
Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

The primary objective of the present study was to investigate the relationship between 25-hydroxyvitamin D (25[OH]D) and areal bone mineral density (aBMD) in Korean subjects from the general population aged ≥50 years. This study included 8,857 individuals who completed the baseline survey of the Dong-gu study, which was conducted in Korea from 2007−2010. The participants who fulfilled the detailed inclusion criteria underwent assessment of the femoral neck and lumbar spine aBMD as well as measurement of serum 25(OH)D and parathyroid hormone (PTH) levels. After adjusting for other covariates and log-PTH values, the mean aBMD of the femoral neck exhibited a significant increase with increasing 25(OH)D levels in both males (p < 0.001) and females (p = 0.005). Additionally, the mean aBMD of the lumbar spine exhibited a significant increase with increasing 25(OH)D levels in males (p = 0.011) but not females (p = 0.252). After adjusting for covariates and log-25(OH)D values, the mean aBMD values of the femoral neck and lumbar spine showed significant decreases with increasing PTH levels in both males and females (p < 0.001). The present findings demonstrate that the aBMD of the femoral neck was significantly associated with 25(OH)D levels independent of PTH in both males and females and that the aBMD of the lumbar spine was significantly associated with 25(OH)D levels independent of PTH in males, but not females.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Lips P (2001) Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 22:477–501

    Article  CAS  PubMed  Google Scholar 

  2. Holick MF (1994) McCollum Award Lecture, 1994: vitamin D–new horizons for the 21st century. Am J Clin Nutr 60:619–630

    CAS  PubMed  Google Scholar 

  3. Holick MF (1999) Evolution, biologic functions, and recommended dietary allowances for vitamin D. In: Procedings of Md MFH (ed) Vitamin D. Humana Press, pp 1–16

  4. Holick MF (1996) Vitamin D and Bone Health. J Nutr 126:1159S–1164S

    CAS  PubMed  Google Scholar 

  5. Aguado P, Campo MTd, Garcés MV, González-Casaús ML, Bernad M, Gijón-Baños J, Mola EM, Torrijos A, Martínez ME (2000) Low vitamin D levels in outpatient postmenopausal women from a rheumatology clinic in madrid, spain: their relationship with bone mineral density. Osteoporos Int 11:739–744

    Article  CAS  PubMed  Google Scholar 

  6. Lips P (2007) Relative value of 25(OH)D and 1,25(OH)2D measurements. J Bone Miner Res 22:1668–1671

    Article  CAS  PubMed  Google Scholar 

  7. Lips P (2006) Vitamin D physiology. Prog Biophys Mol Biol 92:4–8

    Article  CAS  PubMed  Google Scholar 

  8. Lieben L, Carmeliet G, Masuyama R (2011) Calcemic actions of vitamin D: effects on the intestine, kidney and bone. Best Pract Res Clin Endocrinol Metabol 25:561–572

    Article  CAS  Google Scholar 

  9. Sahota O, Mundey MK, San P, Godber IM, Lawson N, Hosking DJ (2004) The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis. Bone 35:312–319

    Article  CAS  PubMed  Google Scholar 

  10. Mezquita-Raya P, Muñoz-Torres M, De Dios Luna J, Luna V, Lopez-Rodriguez F, Torres-Vela E, Escobar-Jiménez F (2001) Relation between vitamin D insufficiency, bone density, and bone metabolism in healthy postmenopausal women. J Bone Miner Res 16:1408–1415

    Article  CAS  PubMed  Google Scholar 

  11. Kweon S-S, Shin M-H, Jeong S-K et al (2013) Cohort profile: the Namwon study and the Dong-gu study. Int J Epidemiol 43:558–567

    Article  PubMed  Google Scholar 

  12. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. modification of diet in renal disease study group. Ann Intern Med 130:461–470

    Article  CAS  PubMed  Google Scholar 

  13. Wu X-P, Liao E-Y, Zhang H, Dai R-C, Shan P-F, Cao X-Z, Liu S-P, Jiang Y (2004) Determination of age-specific bone mineral density and comparison of diagnosis and prevalence of primary osteoporosis in Chinese women based on both Chinese and World Health Organization criteria. J Bone Miner Metab 22:382–391

    PubMed  Google Scholar 

  14. Roy DK, Berry JL, Pye SR, Adams JE, Swarbrick CM, King Y, Silman AJ, O’Neill TW (2007) Vitamin D status and bone mass in UK South Asian women. Bone 40:200–204

    Article  CAS  PubMed  Google Scholar 

  15. Ardawi MSM, Sibiany AM, Bakhsh TM, Qari MH, Maimani AA (2012) High prevalence of vitamin D deficiency among healthy Saudi Arabian men: relationship to bone mineral density, parathyroid hormone, bone turnover markers, and lifestyle factors. Osteoporos Int 23:675–686

    Article  CAS  PubMed  Google Scholar 

  16. Kim G, Oh KW, Jang E-H et al (2012) Relationship between vitamin D, parathyroid hormone, and bone mineral density in elderly Koreans. J Korean Med Sci 27:636–643

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Nakamura K, Tsugawa N, Saito T et al (2008) Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: yokogoshi Study. Bone 42:271–277

    Article  CAS  PubMed  Google Scholar 

  18. Chandran M, Hoeck HC, Wong HC, Zhang RF, Dimai HP (2011) Vitamin D status and its relationship with bone mineral density and parathyroid hormone in Southeast Asian adults with low bone density. Endocr Pract 17:226–234

    Article  PubMed  Google Scholar 

  19. Sigurdsson G, Franzson L, Steingrimsdottir L, Sigvaldason H (2000) The association between parathyroid hormone, vitamin D and bone mineral density in 70-year-old icelandic women. Osteoporos Int 11:1031–1035

    Article  CAS  PubMed  Google Scholar 

  20. Kota S, Jammula S, Kota S, Meher L, Modi K (2013) Correlation of vitamin D, bone mineral density and parathyroid hormone levels in adults with low bone density. Indian J Orthop 47:402–407

    Article  PubMed  PubMed Central  Google Scholar 

  21. Wang TJ, Zhang F, Richards JB et al (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376:180–188

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Hutchinson MS, Grimnes G, Joakimsen RM, Figenschau Y, Jorde R (2010) Low serum 25-hydroxyvitamin D levels are associated with increased all-cause mortality risk in a general population: the Tromsø study. Eur J Endocrinol 162:935–942

    Article  CAS  PubMed  Google Scholar 

  23. Carnevale V, Modoni S, Pileri M, Di Giorgio A, Chiodini I, Minisola S, Vieth R, Scillitani A (2001) Longitudinal evaluation of vitamin D status in healthy subjects from southern Italy: seasonal and gender differences. Osteoporos Int 12:1026–1030

    Article  CAS  PubMed  Google Scholar 

  24. Arabi A, Baddoura R, Awada H, Salamoun M, Ayoub G, El-Hajj Fuleihan G (2006) Hypovitaminosis D osteopathy: is it mediated through PTH, lean mass, or is it a direct effect? Bone 39:268–275

    Article  CAS  PubMed  Google Scholar 

  25. Arya V, Bhambri R, Godbole MM, Mithal A (2004) Vitamin D status and its relationship with bone mineral density in healthy Asian Indians. Osteoporos Int 15:56–61

    Article  CAS  PubMed  Google Scholar 

  26. Boonen S, Bischoff-Ferrari HA, Cooper C, Lips P, Ljunggren O, Meunier PJ, Reginster JY (2006) Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: a review of the evidence. Calcif Tissue Int 78:257–270

    Article  CAS  PubMed  Google Scholar 

  27. Curtis JR, Ewing SK, Bauer DC, Cauley JA, Cawthon PM, Barrett-Connor E, Haney EM, Ishani A, Cremers S, Orwoll E (2012) Association of intact parathyroid hormone levels with subsequent Hip BMD loss: the osteoporotic fractures in men (MrOS) study. J Clin Endocrinol Metab 97:1937–1944

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. von Mühlen DG, Greendale GA, Garland CF, Wan L, Barrett-Connor E (2005) Vitamin D, parathyroid hormone levels and bone mineral density in community-dwelling older women: the Rancho Bernardo study. Osteoporos Int 16:1721–1726

    Article  Google Scholar 

Download references

Acknowledgments

This study was supported by Research Institute of Medical Sciences, Chonnam National University.

Conflict of interest

The authors have no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Preventive Medicine, Chosun University Medical School, 309, Pilmun-daero, Dong-gu, Gwangju, 501-759, Republic of Korea

    Seong-Woo Choi & So-Yeon Ryu

  2. Department of Preventive Medicine, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju, 501-746, Republic of Korea

    Sun-Seog Kweon, Jin-Su Choi, Jung-Ae Rhee & Min-Ho Shin

  3. Jeonnam Regional Cancer Center, Chonnam National University Hwasun, Hwasun Hospital, Gwangju, Republic of Korea

    Sun-Seog Kweon

  4. Department of Preventive Medicine and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, 344-2 Shinyong-dong, Iksan, Jeollabukdo, 570-711, Republic of Korea

    Young-Hoon Lee

  5. Department of Preventive Medicine, Chungnam National University Medical School, Munhwa 1(il)-dong, Jung-gu, Daejeon, 301-747, Republic of Korea

    Hae-Sung Nam

  6. Department of Neurology and Research Institute of Clinical Medicine, Chobuk National University-Biomedical Institute of Chonbuk National University Hospital, San 2-20, Geumam-dong, Deokjin-gu, Jeonju, Jeollabukdo, 561-180, Republic of Korea

    Seul-Ki Jeong

  7. Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Republic of Korea

    Kyeong-Soo Park

  8. Department of Laboratory Medicine, Chonnam National University Hwasun Hospital, 322 Seoyang-ro, Hwasun, Jeollanamdo, 519-809, Republic of Korea

    Hye-Rim Song

  9. Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, Republic of Korea

    Min-Ho Shin

  10. Research Institute of Medical Sciences, Chonnam National University Gwangju, Gwangju, Republic of Korea

    Min-Ho Shin

Authors
  1. Seong-Woo Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sun-Seog Kweon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jin-Su Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jung-Ae Rhee
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Young-Hoon Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hae-Sung Nam
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Seul-Ki Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kyeong-Soo Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. So-Yeon Ryu
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Hye-Rim Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Min-Ho Shin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Min-Ho Shin.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Choi, SW., Kweon, SS., Choi, JS. et al. The association between vitamin D and parathyroid hormone and bone mineral density: the Dong-gu Study. J Bone Miner Metab 34, 555–563 (2016). https://doi.org/10.1007/s00774-015-0696-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00774-015-0696-9

Keywords

Search

Navigation