ORIGINAL ARTICLE

Journal of Bone and Mineral Metabolism

, Volume 25, Issue 2, pp 114-121

Establishment of peak bone mineral density in Southern Chinese males and its comparisons with other males from different regions of China

  • Li-Jun TanAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
  • , Shu-Feng LeiAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
  • , Xiang-Ding ChenAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
  • , Man-Yuan LiuAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
  • , Yan-Fang GuoAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
  • , Hong XuAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
  • , Xiao SunAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
  • , Cheng JiangAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
  • , Su-Mei XiaoAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
    • , Jing-Jing GuoAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
    • , Yan-Jun YangAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
    • , Fei-Yan DengAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
    • , Yan-Bo WangAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
    • , Yuan-Neng LiAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
    • , Xue-Zhen ZhuAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University
    • , Hong-Wen DengAffiliated withLaboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal UniversityDepartment of Orthopedic Surgery, School of Medicine, University of Missouri-Kansas CityLaboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University Email author 

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Abstract

Peak bone mineral density (PBMD) is an important determinant of osteoporotic fracture and a precondition for correct diagnosis of osteoporosis. The objective of this study was to establish the reference data of PBMD at the lumber spine and hip in Southern Chinese males. Bone mineral density (BMD) was measured at the lumbar spine and hip (femoral neck, trochanter, intertrochanter, and total) in 1155 Chinese men aged 15–39 years, using dual-energy X-ray absorptiometry (DXA). We utilized a fit curve method to determine the best age range over which to calculate PBMD. Our results indicated that the PBMD was observed at the age range of 18–25 years at the various sites. The mean value and standard deviation of PBMD was 0.753 ± 0.117, 1.156 ± 0.148, 0.896 ± 0.120, 0.989 ± 0.122, and 0.980 ± 0.116 g/cm2 at the trochanter, intertrochanter, femoral neck, total hip, and spine, respectively. When the present PBMD reference was compared with the documented PBMD reference of males from other regions of China, we found great difference in standardized PBMD between Changsha males and those from other regions of China. The PBMD for Chinese males in Changsha at the various sites were 3.19%–11.33% lower than that for American Caucasian males. In conclusion, the PBMD at the spine and hip may be used as normal reference data for Southern Chinese males in Changsha instead of documented PBMD from other regions of China and the manufacturer's reference data.

Key words

Chinese male geographic difference peak bone mineral density reference data