Abstract
This pilot study examined differences in plasma cell free DNA (CFD) levels based on practice of stress reduction techniques among 14 women undergoing in vitro fertilization (IVF) and embryo transfer (ET) treatment who had higher than normal levels of plasma CFD before beginning IVF treatment. Wilcoxon nonparametric tests were used to examine the significance of the rate of decline in CFD levels between the time points in each of the groups. A paired sample t-test examined the changes in CFD levels among each participant in each of the groups separately. We found that women who engaged in these techniques had reduced plasma CFD, below what is considered elevated in comparison to those who did not practice. High plasma CFD levels have been associated with IVF failure. Stress reduction techniques may facilitate physiological changes that lead to the reduction of plasma CFD levels.
This is a preview of subscription content, log in via an institution to check access.
References
Atamaniuk J, Kopecky C, Skoupy S, Säemann MD, Weichhart T (2012) Apoptotic cell-free DNA promotes inflammation in haemodialysis patients. Nephrol Dial Transplant 27(3):902–905
Czamanski-Cohen J, Sarid O, Cwikel J, Lunenfeld E, Douvdevani A, Levitas E, Har-Vardi I (2013) Increased plasma cell-free DNA is associated with low pregnancy rates among women undergoing IVF-embryo transfer. Reprod BioMed Online 26(1):36–41
Carp HJA, Selmi C, Shoenfeld Y (2012) The autoimmune bases of infertility and pregnancy loss. J Autoimmun 38(2–3):J266–J274
Doering LV, Cross R, Vredevoe D, Martinez-Maza O, Cowan MJ (2007) Infection, depression, and immunity in women after coronary artery bypass: a pilot study of cognitive behavioral therapy. Altern Ther Health Med 13(3):18–21
Domar AD, Zuttermeister PC, Friedman R (1993) The psychological impact of infertility: a comparison with patients with other medical conditions. J Psychosom Obstet Gynaecol 14:45–52
Goldshtein H, Hausmann MJ, Douvdevani A (2009) A rapid direct fluorescent assay for cell-free DNA quantification in biological fluids. Ann Clin Biochem 46(6):488–94
Hofmann SG, Asnaani A, Vonk IJ, Sawyer AT, Fang A (2012) The efficacy of cognitive behavioral therapy: a review of meta-analyses. Cogn Ther Res 36(5):427–440
Irwin M (2002) Psychoneuroimmunology of depression: clinical implications. Brain Behav Immun 16(1):1–16
Lamaita RM, Pontes A, Belo AV, Caetano JPJ, Andrade SP, Cãndido EB, Traiman P, Carneiro MM, Silva-Filho AL (2012) Inflammatory response patterns in ICSI patients. Reprod Sci 19(7):704–711
Rohleder N (2012) Acute and chronic stress induced changes in sensitivity of peripheral inflammatory pathways to the signals of multiple stress systems—2011 Curt Richter Award Winner. Psychoneuroendocrinology 37(3):307–316
Shimony A, Zahger D, Gilutz H, Goldstein H, Orlov G, Merkin M, Shalev A, Ilia R, Douvdevani A (2010) Cell free DNA detected by a novel method in acute ST-elevation myocardial infarction patients. Acute Card Care 12(3):109–111
Suzuki N, Kamataki A, Yamaki J, Homma Y (2008) Characterization of circulating DNA in healthy human plasma. Clin Chim Acta 387(1):55–58
Conflict of interest
None of the authors have any financial disclosures or support.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Czamanski-Cohen, J., Sarid, O., Cwikel, J. et al. Decrease in cell free DNA levels following participation in stress reduction techniques among women undergoing infertility treatment. Arch Womens Ment Health 17, 251–253 (2014). https://doi.org/10.1007/s00737-013-0407-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00737-013-0407-2