Original Contribution

Archives of Women's Mental Health

, Volume 12, Issue 1, pp 27-34

Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees

  • Jennifer L. PayneAffiliated withDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins UniversityDepartment of Mental Health, Johns Hopkins University Email author 
  • , Sarah R. KleinAffiliated withDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins UniversityDepartment of Mental Health, Johns Hopkins University
  • , Rachel B. ZamoiskiAffiliated withDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins UniversityDepartment of Mental Health, Johns Hopkins University
  • , Peter P. ZandiAffiliated withBloomberg School of Public Health, Johns Hopkins University
  • , Oscar J. BienvenuAffiliated withDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins UniversityDepartment of Mental Health, Johns Hopkins University
  • , Dean F. MacKinnonAffiliated withDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins UniversityDepartment of Mental Health, Johns Hopkins University
  • , Francis M. MondimoreAffiliated withDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins UniversityDepartment of Mental Health, Johns Hopkins University
  • , Barbara SchweizerAffiliated withDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins UniversityDepartment of Mental Health, Johns Hopkins University
  • , Karen L. SwartzAffiliated withDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins UniversityDepartment of Mental Health, Johns Hopkins University
    • , NIMH Genetics Initiative Bipolar Disorder Consortium
    • , Raymond P. CroweAffiliated withDepartment of Psychiatry and Mental Health Clinical Research Center, University of Iowa Carver College of Medicine
    • , William A. ScheftnerAffiliated withDepartment of Psychiatry, Rush-Presbyterian Medical Center
    • , Myrna M. WeissmanAffiliated withDepartment of Psychiatry, College of Physicians and Surgeons, Columbia UniversityNew York State Psychiatric Institute
    • , Douglas F. LevinsonAffiliated withDepartment of Psychiatry, Stanford University School of Medicine
    • , J. Raymond DePauloJr.Affiliated withDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins UniversityDepartment of Mental Health, Johns Hopkins University
    • , James B. PotashAffiliated withDepartment of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins UniversityDepartment of Mental Health, Johns Hopkins University

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Abstract

We sought to determine whether premenstrual mood symptoms exhibit familial aggregation in bipolar disorder or major depression pedigrees. Two thousand eight hundred seventy-six women were interviewed with the Diagnostic Interview for Genetic Studies as part of either the NIMH Genetics Initiative Bipolar Disorder Collaborative study or the Genetics of Early Onset Major Depression (GenRED) study and asked whether they had experienced severe mood symptoms premenstrually. In families with two or more female siblings with bipolar disorder (BP) or major depressive disorder (MDD), we examined the odds of having premenstrual mood symptoms given one or more siblings with these symptoms. For the GenRED MDD sample we also assessed the impact of personality as measured by the NEO-FFI. Premenstrual mood symptoms did not exhibit familial aggregation in families with BP or MDD. We unexpectedly found an association between high NEO openness scores and premenstrual mood symptoms, but neither this factor, nor NEO neuroticism influenced evidence for familial aggregation of symptoms. Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use.

Keywords

Premenstrual Bipolar Major depression Genetics