Archives of Women's Mental Health

, 12:27

Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees

Authors

    • Department of Psychiatry and Behavioral Sciences, School of MedicineJohns Hopkins University
    • Department of Mental HealthJohns Hopkins University
  • Sarah R. Klein
    • Department of Psychiatry and Behavioral Sciences, School of MedicineJohns Hopkins University
    • Department of Mental HealthJohns Hopkins University
  • Rachel B. Zamoiski
    • Department of Psychiatry and Behavioral Sciences, School of MedicineJohns Hopkins University
    • Department of Mental HealthJohns Hopkins University
  • Peter P. Zandi
    • Bloomberg School of Public HealthJohns Hopkins University
  • Oscar J. Bienvenu
    • Department of Psychiatry and Behavioral Sciences, School of MedicineJohns Hopkins University
    • Department of Mental HealthJohns Hopkins University
  • Dean F. MacKinnon
    • Department of Psychiatry and Behavioral Sciences, School of MedicineJohns Hopkins University
    • Department of Mental HealthJohns Hopkins University
  • Francis M. Mondimore
    • Department of Psychiatry and Behavioral Sciences, School of MedicineJohns Hopkins University
    • Department of Mental HealthJohns Hopkins University
  • Barbara Schweizer
    • Department of Psychiatry and Behavioral Sciences, School of MedicineJohns Hopkins University
    • Department of Mental HealthJohns Hopkins University
  • Karen L. Swartz
    • Department of Psychiatry and Behavioral Sciences, School of MedicineJohns Hopkins University
    • Department of Mental HealthJohns Hopkins University
  • NIMH Genetics Initiative Bipolar Disorder Consortium
  • Raymond P. Crowe
    • Department of Psychiatry and Mental Health Clinical Research CenterUniversity of Iowa Carver College of Medicine
  • William A. Scheftner
    • Department of PsychiatryRush-Presbyterian Medical Center
  • Myrna M. Weissman
    • Department of Psychiatry, College of Physicians and SurgeonsColumbia University
    • New York State Psychiatric Institute
  • Douglas F. Levinson
    • Department of PsychiatryStanford University School of Medicine
  • J. Raymond DePauloJr.
    • Department of Psychiatry and Behavioral Sciences, School of MedicineJohns Hopkins University
    • Department of Mental HealthJohns Hopkins University
  • James B. Potash
    • Department of Psychiatry and Behavioral Sciences, School of MedicineJohns Hopkins University
    • Department of Mental HealthJohns Hopkins University
Original Contribution

DOI: 10.1007/s00737-008-0043-4

Cite this article as:
Payne, J.L., Klein, S.R., Zamoiski, R.B. et al. Arch Womens Ment Health (2009) 12: 27. doi:10.1007/s00737-008-0043-4

Abstract

We sought to determine whether premenstrual mood symptoms exhibit familial aggregation in bipolar disorder or major depression pedigrees. Two thousand eight hundred seventy-six women were interviewed with the Diagnostic Interview for Genetic Studies as part of either the NIMH Genetics Initiative Bipolar Disorder Collaborative study or the Genetics of Early Onset Major Depression (GenRED) study and asked whether they had experienced severe mood symptoms premenstrually. In families with two or more female siblings with bipolar disorder (BP) or major depressive disorder (MDD), we examined the odds of having premenstrual mood symptoms given one or more siblings with these symptoms. For the GenRED MDD sample we also assessed the impact of personality as measured by the NEO-FFI. Premenstrual mood symptoms did not exhibit familial aggregation in families with BP or MDD. We unexpectedly found an association between high NEO openness scores and premenstrual mood symptoms, but neither this factor, nor NEO neuroticism influenced evidence for familial aggregation of symptoms. Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use.

Keywords

Premenstrual Bipolar Major depression Genetics

Copyright information

© Springer-Verlag 2008