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Acute regulation of IGF-I by alterations in post-exercise macronutrients

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Abstract

This investigation sought to examine the contributions of exercise and nutrient replenishment on in vivo regulation of the insulin-like growth factor-I (IGF-I) axis components. Eight college-aged males completed three high-intensity interval training (HIIT) protocols followed by three post-exercise nutritional protocols: (1) placebo (EX); (2) carbohydrate only (CHO); and (3) essential amino acid/carbohydrate (EAA/CHO). Samples were analyzed for growth hormone (GH), free IGF-I, IGFBP-1, IGFBP-2, insulin, hematocrit, hemoglobin, serum leucine, matrix metalloproteinase-9 (MMP-9) proteolytic activity, and presence of IGFBP-3 protease activity. No evidence for IGFBP-3 proteolysis was observed. Significant increases in [free IGF-I] and [leucine] were observed in the EAA/CHO group only. Significant differences were noted in [IGFBP-1] and [IGFBP-2] across conditions. Significant increases in [GH] and MMP-9 activity were observed in all groups. These results indicate that post-exercise macronutrient ratio is a determinant of [free IGF-I], [IGFBP-1 and -2] and may play a role in modulating the IGF-I axis in vivo.

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Authors and Affiliations

  1. Department of Kinesiology, Auburn University, Auburn, AL, USA

    E. B. Foster, G. Fisher & D. D. Pascoe

  2. Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA

    J. L. Sartin

  3. Bovine Functional Genomics Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, ML, USA

    T. H. Elsasser

  4. Cardiovascular Research Institute, Department of Systems Biology and Translational Medicine, Texas A&M Health Science Center, College Station, TX, USA

    G. Wu

  5. Department of Animal Science, Texas A&M University, College Station, TX, USA

    G. Wu

  6. Department of Health and Physical Education, Athens State University, Athens, AL, USA

    W. Cowan

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  1. E. B. Foster
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  2. G. Fisher
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  3. J. L. Sartin
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  4. T. H. Elsasser
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  5. G. Wu
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Correspondence to E. B. Foster.

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Foster, E.B., Fisher, G., Sartin, J.L. et al. Acute regulation of IGF-I by alterations in post-exercise macronutrients. Amino Acids 42, 1405–1416 (2012). https://doi.org/10.1007/s00726-011-0837-y

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  • DOI: https://doi.org/10.1007/s00726-011-0837-y

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