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Synthesis and investigation of antioxidant activity of the dithiocarbamate derivatives of 9,10-anthracenedione

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Abstract

A variety of new derivatives of 9,10-anthracenedione with mono- and bisdithiocarbamate moiety in the non-catalytic conditions have been synthesized. The obtained compounds were screened for their antioxidant capacity using the cupric-reducing antioxidant capacity (CUPRAC) method. Three of the compounds showed CUPRAC-Trolox equivalent antioxidant capacity (TEAC) coefficients higher than trolox. Scavenging effects on reactive oxygen species (ROS), hydroxyl radical scavenging (HRS), hydrogen peroxide scavenging (HPS), and superoxide anion radical scavenging (SARS) of all synthesized compounds were determined. It was established that the results of HRS-, HPS-, and SARS-CUPRAC methods for three compounds are in accordance with TEAC-CUPRAC assay data.

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Acknowledgments

The authors would like to express their gratitude to the Ministry of Education and Science of Ukraine, Scientific Research Project (Project Number: 0116U004138), and Scientific Research Projects Coordination Unit of Istanbul University (Project Number: NP-45621) for financial support.

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Authors and Affiliations

  1. Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Polytechnic National University, Lviv, Ukraine

    Viktor Zvarych, Maryna Stasevych, Volodymyr Lunin & Volodymyr Novikov

  2. Division of Organic Chemistry, Department of Chemistry, Engineering Faculty, Istanbul University, Istanbul, Turkey

    Nahide Gulsah Deniz & Cigdem Sayil

  3. Division of Analytical Chemistry, Department of Chemistry, Engineering Faculty, Istanbul University, Istanbul, Turkey

    Mustafa Ozyurek & Kubilay Guclu

  4. Department of Mechanism of Organic Reactions, Institute of Organic Chemistry of National Academy of Sciences of Ukraine, Kiev, Ukraine

    Mykhailo Vovk

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  1. Viktor Zvarych
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  2. Maryna Stasevych
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  4. Nahide Gulsah Deniz
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  9. Volodymyr Novikov
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Corresponding author

Correspondence to Maryna Stasevych.

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Zvarych, V., Stasevych, M., Lunin, V. et al. Synthesis and investigation of antioxidant activity of the dithiocarbamate derivatives of 9,10-anthracenedione. Monatsh Chem 147, 2093–2101 (2016). https://doi.org/10.1007/s00706-016-1839-y

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  • DOI: https://doi.org/10.1007/s00706-016-1839-y

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