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Ultrasound-assisted solvent-free synthesis of benzyl nitriles using Amberlite IRA 900 supported cyanide ion

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Abstract

A simple yet effective method for synthesis of benzyl nitriles was developed via ultrasound-assisted cyanation of benzyl halides with Amberlite IRA 900 supported cyanide ion under solvent-free conditions. Benzyl nitriles were obtained in good to excellent yields under short reaction times (10–40 min at 80 °C) with simple work up. The spent polymeric reagent can be recovered and regenerated several times without loss in its reactivity.

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Acknowledgments

The Center of Excellence for Innovation in Chemistry (PERCH-CIC), and the National Research University Project under Thailand’s Office of the Higher Education Commission are gratefully acknowledged for financial support.

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Authors and Affiliations

  1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand

    Sirilak Wangngae, Jindaporn Janprasit, Wong Phakhodee & Mookda Pattarawarapan

Authors
  1. Sirilak Wangngae
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  2. Jindaporn Janprasit
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  3. Wong Phakhodee
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  4. Mookda Pattarawarapan
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Corresponding author

Correspondence to Mookda Pattarawarapan.

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Wangngae, S., Janprasit, J., Phakhodee, W. et al. Ultrasound-assisted solvent-free synthesis of benzyl nitriles using Amberlite IRA 900 supported cyanide ion. Monatsh Chem 145, 1845–1849 (2014). https://doi.org/10.1007/s00706-014-1261-2

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  • DOI: https://doi.org/10.1007/s00706-014-1261-2

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