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DNA interaction studies of pyrazolone- and diimine-incorporated Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes: synthesis, spectroscopic characterization, and antimicrobial study

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Abstract

Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) mixed-ligand complexes were synthesized using 4-[(furan-2-ylmethylene)amino]-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one as the main ligand and 1,10-phenanthroline/2,2′-bipyridine as co-ligand(s). They were characterized by the usual analytical and spectral techniques. The data obtained reveal that the complexes adopt an octahedral geometry around the central metal ions. These complexes were found to be better antimicrobial agents than the free ligands. The DNA (CT) binding properties of the complexes were explored by UV–Vis, viscosity measurements, cyclic voltammetry, differential pulse voltammetry, and molecular docking studies. Binding constants for the above complexes were found to be on the order of 104, indicating that most of the synthesized complexes are partial intercalators. The DNA-cleavage activities of the complexes were also assessed using supercoiled pUC19 DNA and gel electrophoresis, and the results revealed that the hydroxyl radical is likely to be the reactive species responsible for the cleavage of pUC19 DNA by the synthesized complexes.

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Acknowledgments

The authors express their sincere thanks to the Managing Board, the Principal, and the Head of the Department of Chemistry for providing research facilities and moral support. AS thanks the University Grants Commission (UGC) in Hyderabad for financial support.

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Authors and Affiliations

  1. Research Department of Chemistry, VHNSN College, Virudhunagar, Tamil Nadu, 626 001, India

    Arunagiri Sakthivel & Natarajan Raman

  2. Department of Physics and Chemistry, University of Pitetsi, Pitetsi, 110040, Romania

    Liviu Mitu

Authors
  1. Arunagiri Sakthivel
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  2. Natarajan Raman
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  3. Liviu Mitu
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Correspondence to Natarajan Raman.

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Sakthivel, A., Raman, N. & Mitu, L. DNA interaction studies of pyrazolone- and diimine-incorporated Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes: synthesis, spectroscopic characterization, and antimicrobial study. Monatsh Chem 144, 605–620 (2013). https://doi.org/10.1007/s00706-012-0857-7

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  • DOI: https://doi.org/10.1007/s00706-012-0857-7

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