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Squaric acid catalyzed simple synthesis of N-substituted pyrroles in green reaction media

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Abstract

An operationally simple and efficient protocol for squaric acid catalyzed synthesis of N-substituted pyrroles via the reaction of 2,5-dimethoxytetrahydrofuran and 2,5-hexandione with aryl amines in green reaction media (water, deep eutectic solvent, and polyethylene glycol) under ultrasound irradiation or thermal conditions in good to excellent yields has been developed.

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Acknowledgments

The financial support of this work was provided by the Iran National Science Foundation (INSF) and is gratefully appreciated.

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Authors and Affiliations

  1. Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186, Tehran, Iran

    Najmadin Azizi, Anahita Davoudpour, Farshid Eskandari & Ehlham Batebi

Authors
  1. Najmadin Azizi
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  2. Anahita Davoudpour
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  3. Farshid Eskandari
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  4. Ehlham Batebi
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Correspondence to Najmadin Azizi.

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Azizi, N., Davoudpour, A., Eskandari, F. et al. Squaric acid catalyzed simple synthesis of N-substituted pyrroles in green reaction media. Monatsh Chem 144, 405–409 (2013). https://doi.org/10.1007/s00706-012-0841-2

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  • DOI: https://doi.org/10.1007/s00706-012-0841-2

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