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Infection models of human norovirus: challenges and recent progress

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Abstract

Human norovirus (hNoV) infections cause acute gastroenteritis, accounting for millions of disease cases and more than 200,000 deaths annually. However, the lack of in vitro infection models and robust small-animal models has posed barriers to the development of virus-specific therapies and preventive vaccines. Promising recent progress in the development of a norovirus infection model is reviewed in this article, as well as attempts and efforts made since the discovery of hNoV more than 40 years ago. Because suitable experimental animal models for human norovirus are lacking, attractive alternatives are also discussed.

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Acknowledgement

This research was supported by a research grant from Korea Food and Drug Administration (14162-973).

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Authors and Affiliations

  1. School of Food Science and Technology, Chung-Ang University, Anseoung, Gyeongggi, 456-756, South Korea

    Sangdo Ha

  2. Department of Infectious Disease, College of Veterinary Medicine, Konkuk University, Seoul, South Korea

    In-Soo Choi

  3. Department of Food and Nutrition, Chung-Ang University, Anseong, Gyeonggi, 456-756, South Korea

    Changsun Choi

  4. Korea Zoonosis Research Institute, Chonbuk National University, Jeonju, 561-756, Republic of Korea

    Jinjong Myoung

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  1. Sangdo Ha
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  2. In-Soo Choi
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  3. Changsun Choi
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  4. Jinjong Myoung
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Correspondence to Jinjong Myoung.

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Ha, S., Choi, IS., Choi, C. et al. Infection models of human norovirus: challenges and recent progress. Arch Virol 161, 779–788 (2016). https://doi.org/10.1007/s00705-016-2748-4

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  • DOI: https://doi.org/10.1007/s00705-016-2748-4

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