Abstract
The prevalence of HIV-1 infection in men who have sex with men (MSM) in China has drastically increased, and circulating strains may have acquired transmitted drug resistance (TDR). We determined TDR genotypes among antiretroviral therapy (ART)-naïve MSM in 19 provinces/cities where HIV-1 prevalence among MSM is high, and found an overall 4.9 % TDR rate. Although protease inhibitors (PI) were not in the first-line antiretroviral drug list provided through the National ART Program, 70.4 % of the detected TDR belongs to this category. Our findings confirm the urgent need for TDR surveillance in order to optimize treatment effects of the National ART Program.
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Acknowledgments
This work was supported by grants from the Ministry of Science and Technology of China (2008ZX10001-004, 2008ZX10001-010), Chinese State Key Laboratory for Infectious Disease Development Grant (2011SKLID102), and Ministry of Science and Technology of China (2012ZX10001-002). We thank the Heilongjiang CDC, Jilin CDC, Liaoning CDC, Beijing CDC, Hebei CDC, Jiangsu CDC, Shandong CDC, Tianjin CDC, Zhejiang CDC, Hubei CDC, Human CDC, Jiangxi CDC, Shanxi CDC, Guizhou CDC, Sichuan CDC, Gansu CDC, Neimenggu CDC, Ningxia CDC and Qinghai CDC for their support in sample collection and interpretation. We also acknowledge Prof. Marcia Kalish and Prof. Chin-Yih Ou for critical comments.
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705_2012_1557_MOESM1_ESM.tif
Supplementary Figure S1. Phylogenetic neighbor-joining tree for HIV-1 pol sequences. (A) CRF01_AE; (B) CRF07_BC; (C) subtype B. Horizontal branches are drawn in accordance with their relative genetic distances. Bootstrap values of 1,000 replicates are labeled on the major branches. The reference sequences for classifying HIV-1 genotypes were included and were originally obtained from the NIH/NIAID-funded HIV databases. (TIFF 6738 kb)
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Yang, J., Xing, H., Niu, J. et al. The emergence of HIV-1 primary drug resistance genotypes among treatment-naïve men who have sex with men in high-prevalence areas in China. Arch Virol 158, 839–844 (2013). https://doi.org/10.1007/s00705-012-1557-7
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DOI: https://doi.org/10.1007/s00705-012-1557-7