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Molecular phylogeny of modern coxsackievirus A16

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Summary.

A phylogenetic analysis of VP1 and VP4 nucleotide sequences of 52 recent CVA16 strains demonstrated two distinct CVA16 genogroups, A and B, with the prototype strain being the only member of genogroup A. CVA16 G-10, the prototype strain, showed a nucleotide difference of 27.7–30.2% and 19.9–25.2% in VP1 and VP4, respectively, in relation to other CVA16 strains, which formed two separate lineages in genogroup B with nucleotide variation of less than 13.4% and less than 16.3% in VP1 and VP4, respectively. Lineage 1 strains circulating before 2000 were later displaced by lineage 2 strains.

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Authors and Affiliations

  1. Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Sarawak, Malaysia

    D. Perera, M. A. Yusof, Y. Podin, M. H. Ooi & M. J. Cardosa

  2. Institute for Medical Research, Kuala Lumpur, Malaysia

    M. A. Yusof

  3. Sibu Hospital, Sarawak, Malaysia

    M. H. Ooi

  4. Pasteur Institute, Ho Chi Minh City, Vietnam

    N. T. T. Thao, P. V. Tu & N. T. K. Tien

  5. Faculty of Medicine, Universiti Kebangsaan Malaysia, Malaysia

    K. K. Wong & Y. A. Malik

  6. Dr. Fakeeh Hospital, Jeddah, Saudi Arabia

    A. Zaki

  7. National Public Health Laboratory, Sungai Buloh, Selangor, Malaysia

    K. B. Chua

  8. International Medical University, Kuala Lumpur, Malaysia

    Y. A. Malik

  9. Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    P. Puthavathana

  10. Telethon Institute for Child Health Research, Perth, Western Australia

    P. C. McMinn

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  1. D. Perera
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  2. M. A. Yusof
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  3. Y. Podin
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  4. M. H. Ooi
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  7. A. Zaki
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  10. P. V. Tu
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  11. N. T. K. Tien
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  12. P. Puthavathana
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  13. P. C. McMinn
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  14. M. J. Cardosa
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Perera, D., Yusof, M., Podin, Y. et al. Molecular phylogeny of modern coxsackievirus A16. Arch Virol 152, 1201–1208 (2007). https://doi.org/10.1007/s00705-006-0934-5

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  • DOI: https://doi.org/10.1007/s00705-006-0934-5

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