Journal of Neural Transmission

, Volume 121, Issue 2, pp 183–192

NRG3 gene is associated with the risk and age at onset of Alzheimer disease

  • Ke-Sheng Wang
  • Nuo Xu
  • Liang Wang
  • Lorenzo Aragon
  • Radu Ciubuc
  • Tania Bedard Arana
  • ChunXiang Mao
  • Leonora Petty
  • David Briones
  • Brenda Bin Su
  • Xingguang Luo
  • Cynthia Camarillo
  • Michael A. Escamilla
  • Chun Xu
Neurology and Preclinical Neurological Studies - Original Article

DOI: 10.1007/s00702-013-1091-0

Cite this article as:
Wang, KS., Xu, N., Wang, L. et al. J Neural Transm (2014) 121: 183. doi:10.1007/s00702-013-1091-0

Abstract

The Neuregulin 3 (NRG3) gene at 10q22–q24 has been implicated in multiple psychiatric traits such as cognitive impairment. We therefore hypothesized that NRG3 gene polymorphisms may play a role in Alzheimer disease (AD). This present study explored the association of NRG3 with the age at onset (AAO) of AD and the risk of developing AD. Secondary data analysis of 257 single-nucleotide polymorphisms (SNPs) in NRG3 gene was performed in 806 Alzheimer’s disease patients and 782 controls using logistic regression and linear regression analyses. Eight SNPs were associated with the risk of AD (p < 0.05), while linear regression analysis showed 33 SNPs associated with the AAO of AD (p < 0.05). Two-SNP haplotype analyses based on UNPHASED revealed that the G–C haplotype from rs17685233 and rs17101017 was significantly associated with AD (p = 0.0031) and the A–G haplotype from rs504522 and rs474018 as well as the A–G haplotype from rs504522 and rs2483295 were more significantly associated with the AAO of AD (p = 6.72 × 10−5). Using an independent family-based sample, we found one SNP rs11192423 associated with AAO both in the case–control sample (p = 0.0155) and in the family sample (p = 0.0166). In addition, we observed nominally significant associations with AD and AAO for several flanking SNPs (p < 0.05). This is the first study demonstrating that genetic variants in the NRG3 gene play a role in AD. Our results also revealed that SNPs in the NRG3 genes were more strongly associated with AAO of AD.

Keywords

Alzheimer disease Age at onset NRG3 gene Single-nucleotide polymorphisms 

Supplementary material

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Supplementary material 1 (XLSX 42 kb)
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Supplementary material 2 (XLS 77 kb)
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Supplementary material 3 (XLS 36 kb)

Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Ke-Sheng Wang
    • 1
  • Nuo Xu
    • 1
  • Liang Wang
    • 1
  • Lorenzo Aragon
    • 2
  • Radu Ciubuc
    • 2
  • Tania Bedard Arana
    • 3
  • ChunXiang Mao
    • 4
  • Leonora Petty
    • 3
  • David Briones
    • 3
  • Brenda Bin Su
    • 5
  • Xingguang Luo
    • 6
  • Cynthia Camarillo
    • 3
  • Michael A. Escamilla
    • 3
  • Chun Xu
    • 3
  1. 1.Department of Biostatistics and EpidemiologyCollege of Public Health, East Tennessee State UniversityJohnson CityUSA
  2. 2.Department of Family MedicineTexas Tech University Health Sciences Center, Paul L. Foster School of MedicineEl PasoUSA
  3. 3.Department of Psychiatry and Neurology and the Center of Excellence in NeuroscienceTexas Tech University Health Sciences Center, Paul L. Foster School of MedicineEl PasoUSA
  4. 4.University of TorontoTorontoCanada
  5. 5.College of Bioinformatics Science and Technology, Harbin Medical UniversityHarbinThe People’s Republic of China
  6. 6.Department of PsychiatryYale University School of MedicineNew HavenUSA

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