Abstract
Deep brain stimulation (DBS) is a well-established therapy for patients with advanced Parkinson’s disease (PD) with clear benefits on many of the motor symptoms. The effects of DBS on the nonmotor symptoms are less well examined. Emergence of tools to measure the nonmotor burden in PD is now allowing a more objective assessment of impact of DBS on such symptoms. Here we review the pertinent evidence and conclude that, as a therapy, DBS has a major potential to contribute towards the holistic care of PD patients.
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References
Arai E, Arai M, Uchiyama T et al (2012) Subthalamic deep brain stimulation can improve gastric emptying in Parkinson’s disease. Brain 135:1478–1485
Ashkan K, Wallace B, Bell B et al (2004) Deep brain stimulation of the subthalamic nucleus in Parkinson’s disease 1993–2003: where are we 10 years on? Br J Neurosurg 18:19–34
Benabid AL, Pollak P, Louveau A et al (1987) Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. Appl Neurophysiol 50:344–346
Chaudhuri K, Martinez-Martin P, Schapira A et al (2006) An international multicenter pilot study of the first comprehensive self-completed non motor symptoms questionnaire for Parkinson’s disease: the NMSQuest study. Mov Disord 21:916–923
Chaudhuri K, Martinez-Martin P, Brown R et al (2007) The metric properties of a novel non-motor symptoms scale for Parkinson’s disease: results from an international pilot study. Mov Disord 22:1901–1911
De Gaspari D, Siri C, Di Gioia M et al (2006) Clinical correlates and cognitive underpinnings of verbal fluency impairment after chronic subthalamic stimulation in Parkinson’s disease. Parkinsonism Relat Disord 12:289–295
Deuschl G, Schade-Brittimger C, Krak P et al (2006) A randomized trial of deep-brain stimulation for Parkinson’s disease. N Engl J Med 355:896–908
Fasano A, Daniele A, Albanese A (2012) Treatment of motor and non-motor features of Parkinson’s disease with deep brain stimulation. Lancet Neurol 11:429–442
Hinnell C, Hurt C, Landau S et al (2012) Non-motor vs motor symptoms: how much do they matter to health status in Parkinson’s disease? Mov Disord 27:236–241
Hwynn N, Ul Haq I, Malaty I et al (2011) Effect of deep brain stimulation on Parkinson’s nonmotor symptoms following unilateral dbs: a pilot study. Parkinsons Dis. doi:10.4061/2011/507416
Kim HJ, Paek SH, Kim JY et al (2008) Chronic subthalamic deep brain stimulation improves pain in Parkinson disease. J Neurol 255:1889–1894
Kim HJ, Jeon BS, Lee JY et al (2012) The benefit of subthalamic deep brain stimulation for pain in Parkinson disease: a 2-year follow-up study. Neurosurgery 70:18–23
Krack P, Limousin P, Benabid A et al (1997) Chronic stimulation of subthalamic nucleus improves levodopa-induced dyskinesias in Parkinson’s disease. Lancet 350:1676
Krack P, Batir A, Van Blercom N et al (2003) Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N Engl J Med 349:1925–1934
Martinez-Martin P, Schapira A, Stocchi F et al (2007) Prevalence of nonmotor symptoms in Parkinson’s disease in an international setting; study using non-motor symptoms questionnaire in 545 patients. Mov Disord 22:1623–1629
Martinez-Martin P, Rodriguez-Blazquez C, Kurtis M et al (2011) The impact of non-motor symptoms on health-related quality of life of patients with Parkinson’s disease. Mov Disord 26:399–406
Nazzaro J, Pahwa R, Lyons K (2011) The impact of bilateral subthalamic stimulation on non-motor symptoms of Parkinson’s disease. Parkinsonism Relat Disord 17:606–609
Parkinson J (1817) Essay on the shaking palsy. Sherwood, Neely and Jones, London
Reich M, Ray Chaudhuri K, Ashkan K et al (2011) Changes in the non-motor symptom scale in Parkinson’s disease after deep brain stimulation. Basal Ganglia 1:131–133
Shotbolt P, Moriarty J, Costello A et al (2012) Relationships between deep brain stimulation and impulse control disorders in Parkinson’s disease, with a literature review. Parkinsonism Relat Disord 18:10–16
The National Institute for Clinical Excellence (2006) Non-motor features of Parkinson’s disease. In: Guideline Development Group (eds) Parkinson’s disease. Royal College of Physicians, London, pp 113–133
Thobois S, Ardouin C, Lhommee E et al (2010) Non-motor dopamine withdrawal syndrome after surgery for Parkinson’s disease: predictors and underlying mesolimbic denervation. Brain 133:1111–1127
Williams A, Gill S, Varma T et al (2010) Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson’s disease (PD SURG trial): a randomised, open-label trial. Lancet Neurol 9:581–591
Winge K, Nielsen KK, Stimpel H et al (2007) Lower urinary tract symptoms and bladder control in advanced Parkinson’s disease: effects of deep brain stimulation in the subthalamic nucleus. Mov Disord 22:220–225
Witjas T, Kaphan E, Régis J et al (2007) Effects of chronic subthalamic stimulation on nonmotor fluctuations in Parkinson’s disease. Mov Disord 22:1729–1734
Wolz M, Hauschild J, Fauser M et al (2012) Immediate effects of deep brain stimulation of the subthalamic nucleus on nonmotor symptoms in Parkinson’s disease. Parkinsonism Relat Disord 18:994–997
Zibetti M, Torre E, Cinquepalmi A et al (2007) Motor and nonmotor symptom follow-up in parkinsonian patients after deep brain stimulation of the subthalamic nucleus. Eur Neurol 58:218–223
Acknowledgments
Keyoumars Ashkan has received grants for educational trips from Medtronic and St. Jude Medical. Michael Samuel has received honoraria for lectures from UCB, St. Jude Medical and Medtronic. He has received unrestricted educational grants from Solvay and Ipsen. He has received grants for educational trips from Ipsen, Medtronic and UCB. K. Ray Chaudhuri has received honoraria for lectures at symposia from Abbott, UCB, Boehringer-Ingelheim, GSK, Teva and Britannia. He has also had educational grants for research from Abbott, Britannia and UCB.
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Ashkan, K., Samuel, M., Reddy, P. et al. The impact of deep brain stimulation on the nonmotor symptoms of Parkinson’s disease. J Neural Transm 120, 639–642 (2013). https://doi.org/10.1007/s00702-012-0912-x
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DOI: https://doi.org/10.1007/s00702-012-0912-x