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Surfactant assisted enrichment of nucleosides by using a sorbent consisting of magnetic polysulfone capsules and mesoporous silica nanoparticles modified with phenylboronic acid

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Abstract

Boronate affinity materials have been widely used for selective extraction of cis-diols, but their extraction efficiency is far from adequate. We have synthesized porous magnetic polysulfone capsules containing mesoporous silica nanoparticles of type SBA-15 that were functionalized with boronic acid derivative. The spheres were then coated with the cationic surfactant hexadecyltrimethylammonium bromide which binds to the surface due to hydrophobic and ionic interactions. The surfactant coated sorbents possess an enrichment capability and selectivity that is distinctly better than that of non-coated sorbents. The limits of detection for four nucleosides extracted from aqueous sample solutions are in the range from 1.13 to 1.74 ng mL−1. The selective enrichment of trace quantities of nucleosides is illustrated by quantifying nucleosides after extraction from HepG2 cells.

Schematic illustration for the preparation of magnetic polysulfone capsules containing boronate affinity material and its application for enrichment of nucleosides with the combination of hexadecyltrimethylammonium bromide (CTAB).

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Acknowledgments

The authors are thankful for the support of the National Science Foundation of China (no. 21375052, 21575055).

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Authors and Affiliations

  1. State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China

    Ting Cheng, Xiaoyan Liu & Haixia Zhang

  2. Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China

    Yuan Zhang & Xiaoyu Zhang

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  1. Ting Cheng
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  2. Yuan Zhang
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  3. Xiaoyan Liu
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  4. Xiaoyu Zhang
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  5. Haixia Zhang
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Correspondence to Haixia Zhang.

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Cheng, T., Zhang, Y., Liu, X. et al. Surfactant assisted enrichment of nucleosides by using a sorbent consisting of magnetic polysulfone capsules and mesoporous silica nanoparticles modified with phenylboronic acid. Microchim Acta 184, 271–278 (2017). https://doi.org/10.1007/s00604-016-2016-z

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  • DOI: https://doi.org/10.1007/s00604-016-2016-z

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