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The modified Glasgow prognostic score for early mortality in patients with synchronous peritoneal carcinomatosis from colorectal cancer

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Abstract

Purpose

Few studies have investigated the risk factors in patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC) who die within 3 months of undergoing surgical intervention and systemic chemotherapy. This study aimed to identify the risk factors associated with the post-treatment 3-month mortality rate.

Methods

Retrospectively collected data from Hiroshima University were analyzed for patients presenting with synchronous PC from CRC between 1992 and 2012. The clinical, histological and survival data were evaluated and correlated with the overall survival rate at 3 months after surgical intervention.

Results

In patients who underwent surgical intervention with systemic chemotherapy for synchronous PC from CRC (N = 65), a Kaplan–Meier analysis and the log-rank test revealed that systemic chemotherapy (P = 0.023) and the modified Glasgow Prognostic Score (mGPS) (P = 0.00001) were associated with the 3-month mortality rate. Multivariate analyses using these two factors revealed that the mGPS (0/1, 2) (odds ratio 8.087; 95 % CI 1.512–43.25; P = 0.015) was an independent risk factor for the 3-month mortality rate.

Conclusion

The mGPS is an important independent predictor of the 3-month mortality rate in patients who undergo surgical intervention with systemic chemotherapy for synchronous PC from CRC. The mGPS could aid surgeons in choosing the appropriate treatment strategy and best care for patients.

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Acknowledgments

The authors do not have any acknowledgments to make.

Conflict of interest

Tomohiro Adachi and other co-authors have no conflicts of interest to declare.

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Authors and Affiliations

  1. Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima, 7348551, Japan

    Tomohiro Adachi, Takao Hinoi, Hiroyuki Egi, Manabu Shimomura & Hideki Ohdan

  2. Department of Surgery, Division of Frontier Medical Sciences, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi Minami-ku, Hiroshima, Japan

    Minoru Hattori, Yasufumi Saito, Hiroyuki Sawada & Masashi Miguchi

  3. Department of Gastroenterological and Transplant Surgery Division of Medicine, Program of Medicine, Biomedical Sciences Major, Graduate School of Biomedical & Health Sciences, Hiroshima University, Kasumi Minami-ku, Hiroshima, Japan

    Hiroaki Niitsu, Shoichiro Mukai & Takuya Yano

Authors
  1. Tomohiro Adachi
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  2. Takao Hinoi
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  3. Minoru Hattori
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  4. Hiroyuki Egi
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  11. Takuya Yano
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  12. Hideki Ohdan
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Correspondence to Tomohiro Adachi.

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Adachi, T., Hinoi, T., Hattori, M. et al. The modified Glasgow prognostic score for early mortality in patients with synchronous peritoneal carcinomatosis from colorectal cancer. Surg Today 45, 1396–1403 (2015). https://doi.org/10.1007/s00595-014-1080-4

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  • DOI: https://doi.org/10.1007/s00595-014-1080-4

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