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The single-port concept: combining optical glucose measurement with insulin infusion

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Abstract

The aim of this study was to develop a single-port system that combines glucose monitoring and insulin infusion. In a preclinical proof-of-concept trial, the performance of the glucose measurement at the site of insulin infusion was assessed. Glucose levels were clamped from 40 to 250 mg/dL by intravenous glucose infusion and subcutaneous insulin infusion via the glucose sensor. Sensor-glucose values correlated well with reference blood-glucose values, despite infusion at the site of glucose measurement. The average median ARE value was 21.6 ± 5.7 % for sensors used for insulin infusion, 18.1 ± 5.8 % for sensors used for NaCl infusion and 19.2 ± 7.9 % for sensors without infusion. These preclinical in vivo results demonstrate that single-port glucose monitoring is feasible at the site of insulin infusion.

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Acknowledgments

This work was funded by the BMVIT under the project i-Kath.

Conflict of interest

Martin Hajnsek, Barbara Nacht, Stefan Sax, Emil J. W. List, Ingo Klimant, and Frank Sinner declare that they have no conflict of interest.

Human and animal rights

All animal experiments were approved by the Austrian federal government (BMWF-66.010/0117-II/3b/2011) and were performed in consent with Directive 2010/63/EU on the protection of animals used for scientific purposes.

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Authors and Affiliations

  1. HEALTH – Institute for Biomedicine and Health Sciences, Joanneum Research, Graz, Austria

    Martin Hajnsek & Frank Sinner

  2. Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Graz, Austria

    Barbara Nacht & Ingo Klimant

  3. NanoTec Center Weiz, Weiz, Austria

    Stefan Sax & Emil J. W. List

  4. Division of Diabetes and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria

    Frank Sinner

  5. Institute of Solid State Physics, Graz University of Technology, Graz, Austria

    Emil J. W. List

Authors
  1. Martin Hajnsek
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  2. Barbara Nacht
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  3. Stefan Sax
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  4. Emil J. W. List
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  5. Ingo Klimant
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  6. Frank Sinner
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Corresponding author

Correspondence to Frank Sinner.

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Managed by Massimo Porta.

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Hajnsek, M., Nacht, B., Sax, S. et al. The single-port concept: combining optical glucose measurement with insulin infusion. Acta Diabetol 51, 883–886 (2014). https://doi.org/10.1007/s00592-014-0578-y

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  • DOI: https://doi.org/10.1007/s00592-014-0578-y

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