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Follicular adenoma associated with spindle cell proliferation, papillary adenoma and colloid goitre in a dromedary camel

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Abstract

In humans, spindle cell lesions associated with thyroid adenoma or carcinoma are rare. A cross section of the thyroid of a dromedary camel showed follicular cysts, and microscopically, both thyroid lobes showed colloid goitre. The left lobe showed spindle cell proliferation associated with follicular adenoma without evidence of capsular or vascular invasion. The spindle cell lesion had cells featuring ground glass or pseudoinclusion nuclei and showed extensive haemorrhage, hyalinization and thrombosis. The right thyroid lobe showed papillary adenoma. Immunohistochemistry showed negative expression for malignancy. Serum Se, free tri-iodothyronine (fT3) and free thyroxine (fT4) values were low and CK activity was high. The histological features were unusual and merit reporting.

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Acknowledgments

We would like to express our appreciation and gratitude for the staff in Salalah Veterinary Hospital for the help during specimen collection and staff in the Pathology Department, College of Medicine and Health Sciences, Sultan Qaboos University, Sultanate of Oman, for the help in the preparation and staining of the slides.

Conflict of interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Animal and Veterinary Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman

    Mohamed H. Tageldin

  2. PO Box 85689, Al Ain, United Arab Emirates

    Hassan Abu Damir

  3. Veterinary Laboratory, The Department of Agriculture, Al Ain, United Arab Emirates

    Elhag A. Omer

  4. College of Medicine, UAE University, Al Ain, United Arab Emirates

    Mahmoud A. Ali

  5. Laboratories and Animal Research Centre, Directorate general of Veterinary Services, Royal Court Affairs, Muscat, Oman

    Adam M. Adam

Authors
  1. Mohamed H. Tageldin
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  2. Hassan Abu Damir
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  3. Elhag A. Omer
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  4. Mahmoud A. Ali
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  5. Adam M. Adam
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Corresponding author

Correspondence to Hassan Abu Damir.

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Tageldin, M.H., Damir, H.A., Omer, E.A. et al. Follicular adenoma associated with spindle cell proliferation, papillary adenoma and colloid goitre in a dromedary camel. Comp Clin Pathol 25, 241–245 (2016). https://doi.org/10.1007/s00580-015-2183-z

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  • DOI: https://doi.org/10.1007/s00580-015-2183-z

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