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Meniscal lesions and their healing: New aspects

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Abstract

In each healthy knee, there is a pair of crescent-shaped menisci which have a major role in the prevention of early osteoarthritis in the knee joint due to their role in dispersing the load placed across the joint. There are many problems in meniscal repair, and researchers are looking for alternative materials and structures to replace damaged menisci, or ways to increase the quality and speed of healing. In this regard, natural tissues from similar structures or synthetic materials are used and prepared using several different techniques such as tissue engineering or cell culture. Another problem is also considering how to stabilize the joint and the tissue within in it while healing occurs following reconstructive surgery of the meniscus. This review looks at these materials and surgical techniques.

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References

  • Alhalki MM, Howell SM, Hull ML (1999) How three methods for fixing a medial meniscal autograft affect tibial contact mechanics. Am J Sports Med 27:320–328

    CAS  PubMed  Google Scholar 

  • Baker BE, Peckham AC, Pupparo F, Sanborn JC (1985) Review of meniscal injury and associated sports. Am J Sports Med 13:1–4

    Article  CAS  PubMed  Google Scholar 

  • Boulocher C, Duclos ME, Arnault F, Roualdes O, Fau D, Haretmann DJ, Roger T, Vignon E, Viguier E (2008) Knee joint ultrasonography of the ACLT rabbit experimental model of osteoarthritis: relevance and effectiveness in detecting meniscal lesions. Osteoarthr Cartil 16:470–479. doi:10.1016/j.joca.2007.07.012

    Article  CAS  PubMed  Google Scholar 

  • Bradley MP, Fadale PD, Hulstyn MJ, Muirhead WR, Lifrak JT (2007) Porcine small intestine submucosa for repair of goat meniscal defects. Orthopedics 30:650–656

    PubMed  Google Scholar 

  • Brophy RH, Matava MJ (2012) Surgical options for meniscal replacement. J Am Acad Orthop Surg 20:265–272. doi:10.5435/JAAOS-20-05-265

    Article  PubMed  Google Scholar 

  • Bruns J, Kahrs J, Kampen J, Behrens P, Plitz W (1998) Autologous perichondral tissue for meniscal replacement. J Bone Joint Surg (Br) 80-B:918–923

    Article  Google Scholar 

  • Buckwalter JA (2003) Sports, joint injury, and posttraumatic osteoarthritis. J Orthop Sports Phys Ther 33:578–588. doi:10.2519/jospt.2003.33.10.578

    Article  PubMed  Google Scholar 

  • Buckwalter JA, Mankin HJ (1998) Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect 47:487–504

    CAS  PubMed  Google Scholar 

  • Campbell BG (2006) Extracellular matrix bioscaffolds. Proceedings of North American Veterinary Conference (Eds)

  • Chan BP, Leong KW (2008) Scaffolding in tissue engineering: general approaches and tissue-specific considerations. Eur Spine J 17:467–479. doi:10.1007/s00586-008-0745-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chevrier A, Nelea M, Hurtig MB, Hoemann CD, Buschmann MD (2009) Meniscus structure in human, sheep and rabbit for animal models of meniscus repair. J Orthop Res 27:1197–1203. doi:10.1002/jor.20869

    Article  PubMed  Google Scholar 

  • Cole BJ, Carter TR, Rodeo SA (2002) Allograft meniscal transplantation. J Bone Joint Surg Am 84-A:1236–1250

    Google Scholar 

  • Englund M, Guermazi A, Lohmander LS (2009) The meniscus in knee osteoarthritis. Rheum Dis Clin N Am 35:579–590

    Article  Google Scholar 

  • Fabbriciani C, Lucania L, Milano G, Schiavone Panni A, Evangelisti M (1997) Meniscal allografts: cryopreservation vs deep-frozen technique: an experimental study in goats. Knee Surg Sports Traumatol Arthrosc 5:124–134

    Article  CAS  PubMed  Google Scholar 

  • Fattahian HR, Veshkini A, Nasrollahzadeh Massouleh M, Sharifi D (2005) The first report of rheumatoid arthritis in dog in Iran. J Fac Vet Med Tehran Univ 60:95–96

    Google Scholar 

  • Fattahian HR, Mohyeddin H, Molookpour H, Hoseinzadeh H (2009) Retrospective study of surgical treatment of various patellar luxation degrees in dogs 2004–2007: two-year follow-up of patellar luxation reconstruction. Iran J Vet Res 12:56–60

    Google Scholar 

  • Fattahian HR, Mohyeddin H, Hosseinzadeh H, Akbarin H, Moridpour R (2011) Hip arthroplasty: the role of age, weight, degenerative joint disease in prognosis. J Fac Vet Med Univ Kafkas 18:431–436

    Google Scholar 

  • Felson DT (1988) Epidemiology of hip and knee osteoarthritis. Epidemiol Rev 10:1–28

    CAS  PubMed  Google Scholar 

  • Greis PE, Bardana DD, Michael C, Holmstrom MC, Burks RT (2002) Meniscal injury: I. basic science and evaluation. J Am Acad Orthop Surg 10:168–176

    Article  PubMed  Google Scholar 

  • Gultiken ME, Orhan İÖ, Haziroglu RM (2008) The menisci and joint capsule of knee joint in New Zealand rabbit. Ankara Üniv Vet Fak Derg 55:1–5

    Article  Google Scholar 

  • Gunatillake PA, Adhikari R (2003) Biodegradable synthetic polymers for tissue engineering. Eur Cell Mater 5:1–16

    CAS  PubMed  Google Scholar 

  • Hopper RA, Woodhouse K, Semple JL (2003) Acellularization of human placenta with preservation of the basement membrane: a potential matrix for tissue engineering. Ann Plast Surg 51:598–602

    Article  PubMed  Google Scholar 

  • Kambic HE, Futani H, McDevitt CA (2000) Cell, matrix changes and alpha-smooth muscle actin expression in repair of the canine meniscus. Wound Repair Regen 8:554–561. doi:10.1046/j.1524-475x.2000.00554.x

    Article  CAS  PubMed  Google Scholar 

  • Kawamura S, Lotito K, Rodeo SA (2003) Biomechanics and healing response of the meniscus. Oper Tech Sports Med 11:68–76

    Article  Google Scholar 

  • Kobayashi M, Toguchida J, Oka M (2003) Preliminary study of polyvinyl alcohol-hydrogel (PVA-H) artificial meniscus. Biomaterials 24:639–647. doi:10.1016/S0142-9612(02)00378-2

    Article  CAS  PubMed  Google Scholar 

  • Kohn D (1993) Autograft meniscus replacement: experimental and clinical results. Knee Surg Sports Traumatol Arthrosc 1:123–125

    Article  CAS  PubMed  Google Scholar 

  • Lubowitz JH, Verdonk PCM, Reid JB III, Verdonk R (2007) Meniscus allograft transplantation: a current concepts review. Knee Surg Sports Traumatol Arthrosc 15:476–492

    Article  PubMed  Google Scholar 

  • Mandal BB, Park S-H, Gil ES, Kaplan DL (2011) Multilayered silk scaffolds for meniscus tissue engineering. Biomaterials 32:639–651. doi:10.1016/j.biomaterials.2010.08.115

    Article  CAS  PubMed  Google Scholar 

  • Messner K, Gillquist J (1993) Prosthetic replacement of the rabbit medial meniscus. J Biomed Mater Res 27:1165–1173

    Article  CAS  PubMed  Google Scholar 

  • Petrovic V, Stankovic J, Stefanovic V (2011) Tissue engineering of the urinary bladder: current concepts and future perspectives. ScientificWorldJournal 11:1479–1488

    Article  CAS  PubMed  Google Scholar 

  • Proffen BL, McElfresh M, Fleming BC, Murray MM (2011) A comparative anatomical study of the human knee and six animal species. Knee 19:493–499. doi:10.1016/j.knee.2011.07.005

    Article  PubMed  PubMed Central  Google Scholar 

  • Rath E, Richmond JC (2000) The menisci: basic science and advances in treatment. Br J Sports Med 34:252–257. doi:10.1136/bjsm.34.4.252

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Reckers LJ, Fagundes DJ, Cohen M, Raymundo JLP, Moreira MB, Carla Paiva V (2006) Medial meniscus transplantation using cyanoacrylate in rabbits. Acta Cir Bras 21:92–96

    Article  PubMed  Google Scholar 

  • Sandmann GH, Eichhorn S, Vogt S, Adamczyk C, Aryee S, Hoberg M, Milz S, Imhoff AB, Tischer T (2009) Generation and characterization of a human acellular meniscus scaffold for tissue engineering. J Biomed Mater Res A 91A:567–574. doi:10.1002/jbm.a.32269

    Article  CAS  Google Scholar 

  • Shahgaldi BF, Amis AA, Heatley FW, Mcdowell J, Bentley G (1991) Repair of cartilage lesions using biological implants: a comparative histological and biomechanical study in goats. J Bone Joint Surg 73-B:57–64

    Google Scholar 

  • Shelton WR, Dukes AD (1994) Meniscus replacement with bone anchors: a surgical technique. Arthroscopy 10:324–327

    Article  CAS  PubMed  Google Scholar 

  • Stabile KJ, Odom D, Smith TL, Northam C, Whitlock PW, Smith BP, Van Dyke ME, Ferguson CM (2010) An acellular, allograft-derived meniscus scaffold in an ovine model. Arthroscopy 26:936–948. doi:10.1016/j.arthro.2009.11.024

    Article  PubMed  Google Scholar 

  • Stapleton TW, Ingram J, Fisher J, Ingham E (2011) Investigation of the regenerative capacity of an acellular porcine medial meniscus for tissue engineering applications. Tissue Eng A 17:231–242. doi:10.1089/ten.tea.2009.0807

    Article  CAS  Google Scholar 

  • Stärke C, Kopf S, Petersen W, Becker R (2009) Current concepts meniscal repair. Arthroscopy 25:1033–1044. doi:10.1016/j.arthro.2008.12.010

    Article  PubMed  Google Scholar 

  • Steadman JR, Rodkey WG (2005) Tissue-engineered collagen meniscus implants: 5- to 6-year feasibility study results. Arthroscopy 21:515–525. doi:10.1016/j.arthro.2005.01.006

    Article  PubMed  Google Scholar 

  • Stollsteimer GT, Shelton WR, Dukes A, Bomboy AL (2000) Meniscal allograft transplantation: a 1- to 5-year follow-up of 22 patients. Arthroscopy 16:343–347. doi:10.1016/S0749-8063(00)90077-X

    Article  CAS  PubMed  Google Scholar 

  • Stone KR, Walgenbach AW, Abrams JT, Nelson J, Gillett N, Galili U (1997) Porcine and bovine cartilage transplants in cynomolgus monkey: a model for chronic xenograft rejection. Transplantation 63:640–645

    Article  CAS  PubMed  Google Scholar 

  • Tucker B, Khan W, Al-Rashid M, Al-Khateeb H (2012) Tissue engineering for the meniscus: a review of the literature. Open Orthop J 6:348–351. doi:10.2174/1874325001206010348

    Article  PubMed  PubMed Central  Google Scholar 

  • Van der Bracht H, Verdonk R, Verbrugen G, Elewaut D, Verdonk P (2007) Cell-based meniscus tissue engineering. Tissue Eng 3:1–13

    Google Scholar 

  • Van Tienen TG, Hannink G, Buma P (2009) Meniscus replacement using synthetic materials. Clin Sports Med 28:143–156. doi:10.1016/j.csm.2008.08.003

    Article  PubMed  Google Scholar 

  • Vasseur PB (2003) Stifle joint. In: Slatter D (ed) Textbook of small animal surgery, 3rd edn. WB Saunders, Philadelphia, pp 2090–2133

    Google Scholar 

  • Verdonk PCM, Verstraete KL, Almqvist KF, De Cuyper K, Veyss EM, Verbruggen G, Verdonk R (2006) Meniscal allograft transplantation: long-term clinical results with radiological and magnetic resonance imaging correlations. Knee Surg Sports Traumatol Arthrosc 14:694–706

    Article  PubMed  Google Scholar 

  • Warnock JJ, Spina J, Bobe G, Duesterdieck-Zellmer KF, Ott J, Baltzer WI, Bayd BK (2014) Culture of canine synoviocytes on porcine intestinal submucosa scaffolds as a strategy for meniscal tissue engineering for treatment of meniscal injury in dogs. Vet J 199:49–56

    Article  CAS  PubMed  Google Scholar 

  • Welch JA, Lenz SD, Shelton WR (2002) Evaluation of small-intestinal submucosa implants for repair of meniscal defects in dogs. Am J Vet Res 63:427–431

    Article  PubMed  Google Scholar 

  • Wirth CJ, Peters G, Milachowski KA, Weismeier KG, Dieter Kohn D (2002) Long-term results of meniscal allograft transplantation. Am J Sports Med 30:174–181

    PubMed  Google Scholar 

  • Wong ML, Griffiths LG (2014) Immunogenicity in xenogeneic scaffold generation: antigen removal vs. decellularization. Acta Biomater 10:1806–1816

  • Yamasaki T, Deie M, Shinomiya R, Yasunaga Y, Yanada S, Ochi M (2008) Transplantation of meniscus regenerated by tissue engineering with a scaffold derived from a rat meniscus and mesenchymal stromal cells derived from rat bone marrow. Artif Organs 32:519–524

    Article  CAS  PubMed  Google Scholar 

  • Yu Z, Yu-jie L, Jing-xiang H, Bin Z (2011) Development of rabbit meniscus acellular matrix. Acta Acad Med Singap 33:62–65

    CAS  Google Scholar 

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Acknowledgments

The authors wish to thank Dr. Hamid Mohyeddin, Dr. Pejman Mortazavi, Dr. Hamidreza Moosavian, Dr. Saeed Hosseini, and Dr. Roozbeh Moridpour for their assistance.

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Correspondence to Hamidreza Fattahian.

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Saadinam, F., Fattahian, H. & Kajbafzadeh, AM. Meniscal lesions and their healing: New aspects. Comp Clin Pathol 25, 1071–1075 (2016). https://doi.org/10.1007/s00580-014-2017-4

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