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Spirulina platensis ameliorative effect against GSM 900-MHz cellular phone radiation-induced genotoxicity in male Sprague-Dawley rats

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Abstract

The current study was set to explore the possible radioprotective activity of Spirulina platensis (SP) against some genotoxic effects of GSM 900-MHz cellular phone radiation on both bone marrow cells and erythrogram. Sixty adult male Sprague-Dawley rats were divided into four groups, exposed to mobile phone radiation for 6 h/day and/or orally administered 300 mg SP/kg body wt for 30 days. Erythrogram elements, alkaline comet, and micronucleus assays for the detection of DNA damage were estimated besides a histopathological examination of bone marrow tissue. Mobile phone radiation exposure evoked a significant increase in RBC count, Hb concentrations, and packed cell volume (PCV) in addition to marked elevation in the frequencies of micronucleated polychromatic erythrocytes in the peripheral blood and bone marrow compared to control. On the other hand, SP significantly reduced the level of DNA damage and oxidative stress resulted from electromagnetic phone’s radiations. Conclusively, the continuous exposure to mobile phone’s radiation for a long time had a significant adverse genotoxic effect on both bone marrow and hematopoietic system. Yet, SP is proved to be a useful candidate compound in radioprotection.

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Acknowledgments

The author thanks Dr. Mohamed Hamed, Prof. of Pathology, Faculty of Veterinary Medicine, for their assistance in the histopathology.

Conflict of interest

No author of this paper has a conflict of interest, including specific financial interests, relationships, and/or affiliations relevant to the subject matter or materials included in this manuscript.

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Authors and Affiliations

  1. Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt

    Wafaa A. Mohamed & Shimaa A. Ismail

  2. Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt

    Yasmina M. Abd El-Hakim

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  1. Wafaa A. Mohamed
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  2. Shimaa A. Ismail
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  3. Yasmina M. Abd El-Hakim
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Correspondence to Wafaa A. Mohamed.

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Mohamed, W.A., Ismail, S.A. & El-Hakim, Y.M.A. Spirulina platensis ameliorative effect against GSM 900-MHz cellular phone radiation-induced genotoxicity in male Sprague-Dawley rats. Comp Clin Pathol 23, 1719–1726 (2014). https://doi.org/10.1007/s00580-014-2003-x

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  • DOI: https://doi.org/10.1007/s00580-014-2003-x

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