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Nonobese diabetic mice, hypoglycaemia and liver necrosis: a case report

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Abstract

This study investigates a case in a type I diabetic animal model, using nonobese diabetic mice, affected with hypoglycaemia and liver necrosis with other symptomatic complications. This particular animal was markedly different from other animals in the colony, and the investigations we carried out diagnosed various conditions such as growth retardation, frank diabetes, hypoinsulinaemia, hypoglycaemia and multiple foci liver necrosis with nucleomegaly. From the differential diagnosis, we hypothesize that this abnormality might be due to carbohydrate metabolic deficiency giving rise to diabetes and liver necrosis. We postulate that in these conditions, the liver controls the pancreas and that the liver should be the key target organ to control diabetes coupled with hypoglycaemia. Further investigations into the relationship between the carbohydrate metabolism, liver failure and overt diabetes in nonobese diabetic (NOD) animal models might have relevance to human disease.

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Acknowledgments

This study is a part of Research Grant funded by Department of Biotechnology (DBT), Ministry of Science and Technology, Govt. of India, New Delhi. The authors express their gratitude to DBT for their financial support. We thank the Director in charge, National Institute of Nutrition (ICMR), Department of Health Research, Govt. of India, Hyderabad, for their facility and support to work.

Conflict of interest

The authors declare that they have no potential conflict of interest.

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Authors and Affiliations

  1. Department of Stem Cell Research, National Institute of Nutrition (ICMR), Secunderabad, India

    S. Indumathi, B. Padmanav, C. Maniprabha & V. Vijayalakshmi

  2. Department of Pathology, National Institute of Nutrition (ICMR), Secunderabad, India

    P. Uday Kumar

  3. Centre for Laboratory Animal Sciences, National Institute of Nutrition (ICMR), Secunderabad, India

    P. Suresh

  4. Manipal Institute of Regenerative Medicine, Manipal University, Bangalore, India

    R. Bhonde

Authors
  1. S. Indumathi
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  2. B. Padmanav
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  3. P. Uday Kumar
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  4. P. Suresh
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  5. R. Bhonde
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  6. C. Maniprabha
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  7. V. Vijayalakshmi
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Corresponding author

Correspondence to V. Vijayalakshmi.

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Indumathi, S., Padmanav, B., Kumar, P.U. et al. Nonobese diabetic mice, hypoglycaemia and liver necrosis: a case report. Comp Clin Pathol 24, 457–464 (2015). https://doi.org/10.1007/s00580-014-1969-8

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  • DOI: https://doi.org/10.1007/s00580-014-1969-8

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