Abstract
Toxoplasma gondii is one of the major agents of infectious abortions and, due to its worldwide distribution, can threat healthy pregnant women who had no previous exposure to this parasite. The present study was designed to determine the titer of anti-toxoplasma antibody in women with history of abortion visiting Hamedan’s medical centers during 2012–2013. Blood samples were collected from 300 mothers with previous history of abortion coming to the provincial medical centers during the period spanning October 2012 to June 2013. The sera were isolated and subjected to evaluate the anti-toxoplasma IgG antibodies using ELISA method. The result showed IgG positive (IgG+) in 111 cases (37 %); the highest prevalence of T. gondii IgG antibodies was seen in the age of 24–27 years, while the age group 32–39 showed the lowest IgG seroprevalence (3.6 %). Among women with history of abortion, the highest abortion rate (25 %) was seen in the age of 8 weeks (first trimester of pregnancy). Possible routes of infection were contaminated soil, eating raw vegetables rather than eating uncooked meat, or contact with cat. More women from rural areas (63.96 %) had more IgG antibodies to T. gondii than urban women (36.03 %). According to our finding, 63 % of aborted women were serolonegative and at risk of congenital toxoplasmosis for their fetuses. Hence, it is necessary for health policy makers to design the preventive measures against congenital toxoplasmosis.
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Abbas A, Mazloomzadeh S, Haniloo A, Mohammadian E, Fazaeli A (2012) Evaluation of anti-toxoplasma IgG, IgM, and IgA in mothers with spontaneous abortion in Zanjan, northwest of Iran. Korean J Parasitol 50(4):371
Al-Mendalawi MD (2010) The investigation of congenital toxoplasmosis in a tertiary care hospital in Turkey. Saudi Med J 31(1):96
Alvarado-Esquivel C, Torres-Castorena A, Lisenfeid O (2009) Seroepidemiology of Toxoplasma gondii infection in pregnant women in rural Durango, Mexico. J Parasitol 95(2):211–214
Ambroise-Thomas P et al (2001) Prevention of congenital toxoplasmosis in France. Bull Acad Natl Med 185(4):665–683
Berger F, Goulet V, Lestrat Y, Desenclos JC (2009) Toxoplasmosis among pregnant women in France: risk factors and change of prevalence between 1995 and 2003. Rev Epidemiol Sante Publique 57(4):247–248
Bowie WR et al (1997) Outbreak of toxoplasmosis associated with municipal drinking water. Lancet 350(9072):173–177
Boyer KM, Holfels E, Roizen N (2005) Risk factor for Toxoplasma gondii infection in mother of infant with congenital toxoplasmosis: implication for prenatal management and screening. Am J Obstet Gynecol 192(2):564–571
Fallah E, Navazesh R, Najidi J (2005) An epidemiological study of toxoplasma infection among highschool girls in Julfa. J Repord Infertil 15(2):9
Haj-Soleymani F (2008) Determination of anti-toxoplasma IgM, IgG antibodies in pregnant women referred to the medical centers of Zanjan, Iran. Dissertation to Zanjan University of Medical Sciences, Zanjan, Iran
Iqbal J, Khalid N (2007) Detection of acute Toxoplasma gondii infection in early pregnancy by IgG avidity and PCR analysis. J Med Microbiol 56(11):1495–1499
Lopez A et al (2000) Preventing congenital toxoplasmosis. MMWR Recomm Rep 49(RR-2):59–68
Miron D, Raz R, Luder A (2002) Congenital toxoplasmosis in Israel: to screen or not to screen. Israel Med Assoc J 4(2):119–122
Mohammadi P, Taherpor A, Mohammadi H (2006) Seroepidemiology of toxoplasmosis among women referring to premarriage consulting centers in Sanandaj province in 2006. Iran J Infect Dis Trop Med 40(1):5
Montoya JG, Kovacs JA, Remington JS (2005) Toxoplasma gondii. In: Mandell GL, Benett JE, Dolin R, Mandell D (eds) Principles and practice of infectious disease. Elsevier Churchill Livingstone, Philadelphia, pp 3170–3198
Nijem KI, AL-Amleh S (2009) Seroprevalence and associated risk factors of toxoplasmosis in pregnant women in Herbon district, Palestine. East Mediterr Health J 15(5):1278–1284
Rollinson D, Hay SI (2010) Advances in parasitology. Preface Adv Parasitol 71:ix
Sarkar MD, Anuradha B, Sharma N, Roy RN (2012) Seropositivity of toxoplasmosis in antenatal women with bad obstetric history in a tertiary-care hospital of Andhra Pradesh, India. J Health Popul Nutr 30(1):87–92
Shoaei H (2002) Study of the frequency of Toxoplasma infection in pregnant women referred to Imam Hossein Hospital in Zanjan using ELISA method. Dissertation to Tehran University of Medical Sciences, Tehran, Iran
Shuhaiber S et al (2003) Seroprevalence of Toxoplasma gondii infection among veterinary staff in Ontario, Canada (2002): implications for teratogenic risk. BMC Infect Dis 3(1):8
Song KJ, Shin JC, Shin HJ, New HW (2005) Seroprevalence of toxoplasmosis in Korean pregnant women. Korean J Parasitol 43(2):69–71
Stray-Pedersen B (1993) Toxoplasmosis in pregnancy. Baillière’s Clin Obstr Gynaecol 7(1):107–137
Szenasi Z et al (2005) Toxoplasmosis surveillance during pregnancy and quality assurance of methods in Hungary. Wien Klin Wochenschr 117(4):29–34
Thulliez P (1992) Screening programme for congenital toxoplasmosis in France. Scand J Infect Dis 84:43–45
Torda A (2001) Toxoplasmosis. Are cats really the source. Aust Fam Physician 30(8):743–747
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Abedi, M., Heidari, H., Sadeghi Dehkordi, Z. et al. Serological study of toxoplasmosis in women with previous history of abortion at Hamedan’s medical centers during 2012–2013. Comp Clin Pathol 24, 589–592 (2015). https://doi.org/10.1007/s00580-014-1951-5
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DOI: https://doi.org/10.1007/s00580-014-1951-5