Abstract
Alloxan is used for treatment of insulinoma in humans and to induce experimental diabetes in animals. The objective of this research was to study the clinicopathological abnormalities induced by alloxan in goats and to evaluate induced diabetes mellitus disease in goats. Eight goats were divided into treatment (n=4) and control (n=4) groups. After intravenous glucose tolerance tests (IVGTT), goats in the treatment group were injected with 80 mg/kg BW alloxan monohydrate intravenously. Clinical findings in the treatment group included hyperglycemia, glycosuria, ketonemia, ketonuria, polyuria, polydipsia, polyphagia, depression, and pulmonary and dermal infections during the study period. Hematological investigations in the treated goats showed a significant decrease in RBC, Hb, PCV, and lymphocytes (p<0.05) and a significant decrease in neutrophil count (p<0.05). Biochemical investigations in the treatment group indicated a significant increase in glucose, BUN, triglyceride, and total protein levels (p<0.05) but a significant decrease in cholesterol (p<0.05). Urinalysis showed the presence of glucose, ketone bodies, protein, leukocyte, and blood in the urine of the treated goats as well as a decrease in pH.
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Haghdoost, I.S., Ghaleshahi, A.J. & Safi, S. Clinicopathological findings of diabetes mellitus induced by alloxan in goats. Comp Clin Pathol 16, 53–59 (2007). https://doi.org/10.1007/s00580-006-0627-1
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DOI: https://doi.org/10.1007/s00580-006-0627-1