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Flexible Prussian blue/Carbon dots nanocomposite modified exfoliated graphite paper based sensor for simultaneous monitoring of hypertension and Parkinson disease

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Abstract

Patients with hypertension are seriously affected by Parkinson’s disease than patients with normal blood pressure. Thus, early detection of hypertension and Parkinson disease by monitoring subtle changes in specific biomarkers from body fluids can minimize the risk. This paper proposes a flexible, portable paper-based sensor for simultaneous electrochemical sensing of dopamine and uric acid, using differential pulse voltammetry and electrochemical impedance spectroscopy on electrodeposited Prussian blue on carbon dots@graphite paper. The characteristic peaks of dopamine and uric acid in the differential pulse voltammogram are well separated. Further surface characterization of Prussian blue/carbon dots@graphite paper was carried out by Raman Spectra and Scanning Electron Microscope (SEM). The proposed sensor promoted the fast electrochemical detection of dopamine and uric acid with the linear response for concentrations from 0.2–920.0 μM with a limit of detection 0.015 μM, respectively in an aqueous sample. Excellent flexing stability is demonstrated by the proposed sensor, which can maintain its initial current after being bent more than 300 times.

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Acknowledgment

This study was partly supported by the Grant-in-Aid for Scientific Research (Category A, Project No. 17H01224) from the Japan Society for the Promotion of Science (JSPS), the Centre Of Innovation (COI) program from the Japan Science and Technology Agency (JST), the Strategic Innovation Creation Project (SIP) from the New Energy and Industrial Technology Development Organization (NEDO) of Japan, and the Program on Open Innovation Platform with Enterprises, Research Institute and Academia (OPERA) from the JST.

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Authors and Affiliations

  1. Department of Chemistry, MVJ College of Engineering, Whitefield, Bengaluru, 560067, India

    Indu Pandey & Praveen K. Sekhar

  2. Product Engineering and Services, KPIT Technologies Limited, Bellandur, Bengaluru, 560103, India

    Jai Deo Tiwari

  3. Nanomaterials and Sensors Laboratory, School of Engineering and Computer Science (ENCS), Washington State University Vancouver (WSU Vancouver), Vancouver, WA, 98686, USA

    Praveen K. Sekhar

  4. Department of Mechanical System Engineering, Graduate School of Science and Engineering, Yamagata University, Jonan 4-3-16, Yonezawa, 992-8510, Yamagata, Japan

    Hidemitsu Furukawa & Ajit Khosla

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  1. Indu Pandey
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  2. Jai Deo Tiwari
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  3. Hidemitsu Furukawa
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  4. Ajit Khosla
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  5. Praveen K. Sekhar
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Correspondence to Praveen K. Sekhar.

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Pandey, I., Tiwari, J.D., Furukawa, H. et al. Flexible Prussian blue/Carbon dots nanocomposite modified exfoliated graphite paper based sensor for simultaneous monitoring of hypertension and Parkinson disease. Microsyst Technol 28, 109–119 (2022). https://doi.org/10.1007/s00542-019-04468-2

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  • DOI: https://doi.org/10.1007/s00542-019-04468-2

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