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Stochastic sensors based on maltodextrins for screening of whole blood for neuron specific enolase, carcinoembryonic antigen and epidermal growth factor receptor

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Abstract

Stochastic sensors based on maltodextrins with different dextrose equivalent were proposed for the assay of three lung cancer biomarkers: neuron specific enolase, carcinoembryonic antigen and epidermal growth factor receptor. The two sensors proposed can determine simultaneously NSE, CEA and HER-1 in whole blood samples (qualitative and quantitative), with recoveries higher than 97.00 %, and low RSD (%), lower than 0.1 %. This screening test may serve for fast and early detection of lung cancer.

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Acknowledgments

This work was supported by: UEFISCDI PNII Program Ideas 2011–2014, Contract nr. 123/05.10.2011. Ionela Raluca Comnea-Stancu is thankful for the funding from the Sectorial Operational Programme Human Resources Development 2007–2013 of the Ministry of European Funds through the Financial Agreement POSDRU/159/1.5/S/132395.

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Authors and Affiliations

  1. Laboratory of Electrochemistry and PATLAB Bucharest, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei St., 060021, Bucharest, Romania

    Ionela Raluca Comnea-Stancu, Raluca-Ioana Stefan-van Staden & Jacobus Frederick van Staden

  2. Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1-7 Polizu St., 011061, Bucharest, Romania

    Ionela Raluca Comnea-Stancu & Raluca-Ioana Stefan-van Staden

  3. Department of Surgery 4, University of Medicine and Pharmacy “Carol Davila”, 8 Eroii Sanitari St., 050474, Bucharest, Romania

    Camelia Stanciu-Gavan

Authors
  1. Ionela Raluca Comnea-Stancu
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  2. Raluca-Ioana Stefan-van Staden
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  3. Jacobus Frederick van Staden
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  4. Camelia Stanciu-Gavan
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Corresponding author

Correspondence to Raluca-Ioana Stefan-van Staden.

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Comnea-Stancu, I.R., Stefan-van Staden, RI., van Staden, J.F. et al. Stochastic sensors based on maltodextrins for screening of whole blood for neuron specific enolase, carcinoembryonic antigen and epidermal growth factor receptor. Microsyst Technol 22, 25–29 (2016). https://doi.org/10.1007/s00542-015-2635-z

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  • DOI: https://doi.org/10.1007/s00542-015-2635-z

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