Abstract
The protective effect of indigo on intestinal epithelial cells remains unclear. Yokote Akihito et al. preliminarily investigated the anti-ferroptosis effect of indigo in inflammatory bowel disease. Here, we further discuss and evaluate the role of indigo based on the results.
References
Yokote A, Imazu N, Umeno J, et al. Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis. J Gastroenterol. 2023;58:868–82.
Stockwell BR, Friedmann JP, Bayir H, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171:273–85.
Xu M, Tao J, Yang Y, et al. Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis. Cell Death Dis. 2020;11:86.
Sun SP, Lu YF, Li H, et al. AMPK activation alleviated dextran sulfate sodium-induced colitis by inhibiting ferroptosis. J Dig Dis. 2023;24:213–23.
Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72.
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Sun, S., Lv, B. The antiferroptotic effect of indigo on ulcerative colitis. J Gastroenterol 59, 75–76 (2024). https://doi.org/10.1007/s00535-023-02063-x
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DOI: https://doi.org/10.1007/s00535-023-02063-x