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Molecular mechanism of iron metabolism and overload in chronic hepatitis C

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References

  1. MW Hentze MU Muckenthaler NC Andrews (2004) ArticleTitleBalancing acts: molecular control of mammalian iron metabolism Cell 117 285–97 10.1016/S0092-8674(04)00343-5 Occurrence Handle10.1016/S0092-8674(04)00343-5 Occurrence Handle1:CAS:528:DC%2BD2cXjvFemsbg%3D Occurrence Handle15109490

    Article  CAS  PubMed  Google Scholar 

  2. HJH Fenton (1894) ArticleTitleOxidation of tartaric acid in presence of iron J Chem Soc 65 899–910 Occurrence Handle1:CAS:528:DyaD28XmtlCnsQ%3D%3D

    CAS  Google Scholar 

  3. AT McKie D Barrow GO Latunde A Rolfs G Sager E Mudaly et al. (2001) ArticleTitleAn iron-regulated ferric reductase associated with the absorption of dietary iron Science 291 1755–9 10.1126/science.1057206 Occurrence Handle10.1126/science.1057206 Occurrence Handle1:CAS:528:DC%2BD3MXhslSkurY%3D Occurrence Handle11230685

    Article  CAS  PubMed  Google Scholar 

  4. H Gunshin B Mackenzie Y Gunshin MF Romero WF Boron S Nussberger et al. (1997) ArticleTitleCloning and characterization of a mammalian proton-coupled metal-ion transporter Nature 388 482–8 10.1038/41343 Occurrence Handle10.1038/41343 Occurrence Handle1:CAS:528:DyaK2sXltFGqtbY%3D Occurrence Handle9242408

    Article  CAS  PubMed  Google Scholar 

  5. A Donovan A Brownlie Y Zhou J Shepard SJ Pratt J Moynihan et al. (2000) ArticleTitlePositional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter Nature 403 776–81 10.1038/35001596 Occurrence Handle10.1038/35001596 Occurrence Handle1:CAS:528:DC%2BD3cXhsVWitrY%3D Occurrence Handle10693807

    Article  CAS  PubMed  Google Scholar 

  6. CD Vulpe YM Kuo T Murphy L Cowley C Askwith N Libina et al. (1999) ArticleTitleHephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the ala mouse Nat Genet 21 195–9 10.1038/5979 Occurrence Handle10.1038/5979 Occurrence Handle1:CAS:528:DyaK1MXpsVCktg%3D%3D Occurrence Handle9988272

    Article  CAS  PubMed  Google Scholar 

  7. FM von Bockxmeer EH Morgan (1977) ArticleTitleIdentification of transferring receptors in reticulocytes Biochim Biophys Acta 468 437–50 10.1016/0005-2736(77)90293-0 Occurrence Handle10.1016/0005-2736(77)90293-0

    Article  Google Scholar 

  8. D Trinder O Zak P Aisen (1996) ArticleTitleTransferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expression Hepatology 23 1512–20 10.1002/hep.510230631 Occurrence Handle10.1002/hep.510230631 Occurrence Handle1:CAS:528:DyaK28Xkt1ensb8%3D Occurrence Handle8675172

    Article  CAS  PubMed  Google Scholar 

  9. H Kawabata R Yang T Hirama PT Vuong S Kawano AF Gombart et al. (1999) ArticleTitleMolecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family J Biol Chem 274 20826–32 10.1074/jbc.274.30.20826 Occurrence Handle10.1074/jbc.274.30.20826 Occurrence Handle1:CAS:528:DyaK1MXkvVKkur0%3D Occurrence Handle10409623

    Article  CAS  PubMed  Google Scholar 

  10. CH Park EV Volore AJ Waring T Ganz (2001) ArticleTitleHepcidin, a urinary antimicrobial peptide synthesized in the liver J Biol Chem 276 7806–10 10.1074/jbc.M008922200 Occurrence Handle10.1074/jbc.M008922200 Occurrence Handle1:CAS:528:DC%2BD3MXitFKhtbo%3D Occurrence Handle11113131

    Article  CAS  PubMed  Google Scholar 

  11. G Nicoras L Viatte M Bennoun C Beaumont A Kahn S Vaulont (2002) ArticleTitleHepcidin, a new iron regulatory peptide Blood Cells Mol Dis 29 327–35 10.1006/bcmd.2002.0573 Occurrence Handle10.1006/bcmd.2002.0573

    Article  Google Scholar 

  12. T Ganz (2003) ArticleTitleHepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation Blood 102 783–8 10.1182/blood-2003-03-0672 Occurrence Handle10.1182/blood-2003-03-0672 Occurrence Handle1:CAS:528:DC%2BD3sXlvFCms7g%3D Occurrence Handle12663437

    Article  CAS  PubMed  Google Scholar 

  13. E Nemeth MS Tuttle J Powelson MB Vaughn A Donovan DM Ward et al. (2004) ArticleTitleHepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 306 2090–3 10.1126/science.1104742 Occurrence Handle10.1126/science.1104742 Occurrence Handle1:CAS:528:DC%2BD2cXhtVOjsL3K Occurrence Handle15514116

    Article  CAS  PubMed  Google Scholar 

  14. AM Di Bisceglie CA Axiotis JH Hoofnagle BR Bacon (1992) ArticleTitleMeasurements of iron status in patients with chronic hepatitis Gastroenterology 102 2108–13 Occurrence Handle1:STN:280:DyaK383msleitA%3D%3D Occurrence Handle1587431

    CAS  PubMed  Google Scholar 

  15. F Farinati R Cardin N De Maria G Della Libera C Marafin E Lecis et al. (1995) ArticleTitleIron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis J Hepatol 22 449–56 10.1016/0168-8278(95)80108-1 Occurrence Handle10.1016/0168-8278(95)80108-1 Occurrence Handle1:STN:280:DyaK2MzpsFagtQ%3D%3D Occurrence Handle7545199

    Article  CAS  PubMed  Google Scholar 

  16. T Isomura M Yano H Hayashi N Sakamoto (1992) ArticleTitleExcess iron in the liver of patients with chronic hepatitis C J Clin Electron Microsc 25 231–7

    Google Scholar 

  17. SE Bassett AM Di Bisceglie BR Bacon RM Sharp S Govindarajan GB Hubbard et al. (1999) ArticleTitleEffects of iron loading on pathogenicity in hepatitis C virus-infected chimpanzees Hepatology 29 1884–92 10.1002/hep.510290623 Occurrence Handle10.1002/hep.510290623 Occurrence Handle1:CAS:528:DyaK1MXjvFOmsb0%3D Occurrence Handle10347134

    Article  CAS  PubMed  Google Scholar 

  18. H Hayashi T Takikawa N Nishimura M Yano T Isomura N Sakamoto (1994) ArticleTitleImprovement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C Am J Gastroenterol 89 986–8 Occurrence Handle1:STN:280:DyaK2c3ovVSiuw%3D%3D Occurrence Handle8017395

    CAS  PubMed  Google Scholar 

  19. H Hayashi T Takikawa N Nishimura M Yano (1995) ArticleTitleSerum aminotransferase levels as an indicator of the effectiveness of venesection for chronic hepatitis C J Hepatol 22 268–71 10.1016/0168-8278(95)80278-9 Occurrence Handle10.1016/0168-8278(95)80278-9 Occurrence Handle1:STN:280:DyaK2Mzjt1Knuw%3D%3D Occurrence Handle7608476

    Article  CAS  PubMed  Google Scholar 

  20. M Iwasa M Kaito J Ikoma Y Kobayashi Y Tanaka K Higuchi et al. (2002) ArticleTitleDietary iron restriction improves aminotransferase levels in chronic hepatitis C patients Hepatogastroenterology 49 529–31 Occurrence Handle1:CAS:528:DC%2BD38XjslKhsrk%3D Occurrence Handle11995488

    CAS  PubMed  Google Scholar 

  21. M Iwasa K Iwata M Kaito J Ikoma M Yamamoto M Takeo et al. (2004) ArticleTitleEfficacy of long-term dietary restriction of total calories, fat, iron, and protein in patients with chronic hepatitis C virus Nutrition 20 368–71 10.1016/j.nut.2003.12.009 Occurrence Handle10.1016/j.nut.2003.12.009 Occurrence Handle1:CAS:528:DC%2BD2cXisVemtLk%3D Occurrence Handle15043853

    Article  CAS  PubMed  Google Scholar 

  22. M Takeo Y Kobayashi N Fujita N Urawa M Iwasa S Horiike et al. (2005) ArticleTitleUpregulation of transferrin receptor 2 and ferroportin 1 mRNA in the liver of patients with chronic hepatitis C J Gastroenterol Hepatol 20 562–9 10.1111/j.1440-1746.2005.03770.x Occurrence Handle10.1111/j.1440-1746.2005.03770.x Occurrence Handle1:CAS:528:DC%2BD2MXls1aqt70%3D Occurrence Handle15836704

    Article  CAS  PubMed  Google Scholar 

  23. Fujita N, Sugimoto R, Takeo M, Urawa N, Mifuji R, Tanaka H, et al. Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C. Mol Med 2007;13

  24. J Kato M Kobune T Nakamura G Kuroiwa K Takada R Takimoto et al. (2001) ArticleTitleNormalization of elevated hepatic 8-hydroxy-2′-deoxyguanousine levels in chronic hepatitis C patients by phlebotomy and low iron diet Cancer Res 61 8697–702 Occurrence Handle1:CAS:528:DC%2BD38Xht1Ogug%3D%3D Occurrence Handle11751387

    CAS  PubMed  Google Scholar 

  25. V Paradis P Mathurin M Kollinger F Imbert-Bismut F Charlotte A Piton et al. (1997) ArticleTitleIn situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features J Clin Pathol 50 401–6 Occurrence Handle10.1136/jcp.50.5.401 Occurrence Handle1:STN:280:DyaK2szlsl2nsA%3D%3D Occurrence Handle9215123

    Article  CAS  PubMed  Google Scholar 

  26. LM Coussens Z Werb (2002) ArticleTitleInflammation and cancer Nature 420 860–7 10.1038/nature01322 Occurrence Handle10.1038/nature01322 Occurrence Handle1:CAS:528:DC%2BD38XpsFygtb4%3D Occurrence Handle12490959

    Article  CAS  PubMed  Google Scholar 

  27. S Horiike S Kawanishi M Kaito N Ma H Tanaka N Fujita et al. (2005) ArticleTitleAccumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C J Hepatol 43 403–10 10.1016/j.jhep.2005.03.026 Occurrence Handle10.1016/j.jhep.2005.03.026 Occurrence Handle1:CAS:528:DC%2BD2MXntVCkurg%3D Occurrence Handle16023246

    Article  CAS  PubMed  Google Scholar 

  28. LA Loeb BD Preston (1986) ArticleTitleMutagenesis by apurinic/apyrimidinic sites Annu Rev Genet 20 201–30 10.1146/annurev.ge.20.120186.001221 Occurrence Handle10.1146/annurev.ge.20.120186.001221 Occurrence Handle1:CAS:528:DyaL2sXmtFyltQ%3D%3D Occurrence Handle3545059

    Article  CAS  PubMed  Google Scholar 

  29. V Yermilov J Rubio H Ohshima (1995) ArticleTitleFormation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination FEBS Lett 376 207–10 10.1016/0014-5793(95)01281-6 Occurrence Handle10.1016/0014-5793(95)01281-6 Occurrence Handle1:CAS:528:DyaK2MXhtVSgsbbF Occurrence Handle7498543

    Article  CAS  PubMed  Google Scholar 

  30. H Huang H Fuji A Sankila BM Mahler-Araujo M Matsuda G Cathomas et al. (1999) ArticleTitleBeta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection Am J Pathol 155 1795–801 Occurrence Handle1:CAS:528:DC%2BD3cXit1KitQ%3D%3D Occurrence Handle10595907

    CAS  PubMed  Google Scholar 

  31. T Furutani K Hino M Okuda T Gondo S Nishina A Kitase et al. (2006) ArticleTitleHepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein Gastroenterology 130 2087–98 10.1053/j.gastro.2006.02.060 Occurrence Handle10.1053/j.gastro.2006.02.060 Occurrence Handle1:CAS:528:DC%2BD28XntVWit78%3D Occurrence Handle16762631

    Article  CAS  PubMed  Google Scholar 

  32. M Yano H Hayashi K Yoshioka Y Saito Y Niitsu J Kato et al. (2004) ArticleTitleA significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: a multicenter, prospective, randomized, controlled trial in Japan J Gastroenterol 39 570–4 10.1007/s00535-003-1344-z Occurrence Handle10.1007/s00535-003-1344-z Occurrence Handle1:CAS:528:DC%2BD2cXlt1ylsLk%3D Occurrence Handle15235875

    Article  CAS  PubMed  Google Scholar 

  33. M Kaito M Iwasa Y Kobayashi N Fujita H Tanaka EC Gabazza et al. (2006) ArticleTitleDecreased lipid peroxidation after phlebotomy in patients with chronic hepatitis C J Gastroenterol 41 921–2 10.1007/s00535-006-1871-5 Occurrence Handle10.1007/s00535-006-1871-5 Occurrence Handle17048059

    Article  PubMed  Google Scholar 

  34. N Tanaka A Horiuchi T Yamaura M Komatsu E Tanaka K Kiyosawa (2007) ArticleTitleEfficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study J Gastroenterol 42 49–55 Occurrence Handle10.1007/s00535-006-1967-y Occurrence Handle1:CAS:528:DC%2BD2sXitVOltL4%3D Occurrence Handle17322993

    Article  CAS  PubMed  Google Scholar 

  35. A Sangiovanni E Colombo F Radaelli A Bortoli G Bovo MA Casiraghi et al. (2001) ArticleTitleHepatocyte proliferation and risk of hepatocellular carcinoma in cirrhotic patients Am J Gastroenterol 96 1575–80 10.1111/j.1572-0241.2001.03780.x Occurrence Handle10.1111/j.1572-0241.2001.03780.x Occurrence Handle1:STN:280:DC%2BD3M3ptF2jtw%3D%3D Occurrence Handle11374702

    Article  CAS  PubMed  Google Scholar 

  36. K Iwata M Iwasa N Hara A Matsumoto Y Kobayashi S Watanabe et al. (2006) ArticleTitleIron content and consumption of health foods by patients with chronic hepatitis C J Gastroenterol 41 919–20 10.1007/s00535-006-1860-8 Occurrence Handle10.1007/s00535-006-1860-8 Occurrence Handle17048058

    Article  PubMed  Google Scholar 

  37. AJ Patek J Post (1941) ArticleTitleTreatment of cirrhosis of the liver by a nutritious diet and supplements rich in vitamin B complex J Clin Invest 20 481–90 Occurrence Handle10.1172/JCI101242 Occurrence Handle1:CAS:528:DyaH3MXltFyktQ%3D%3D Occurrence Handle16694854

    Article  CAS  PubMed  Google Scholar 

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  1. Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Science, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Masahiko Kaito M.D.

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Kaito, M. Molecular mechanism of iron metabolism and overload in chronic hepatitis C. J Gastroenterol 42, 96–99 (2007). https://doi.org/10.1007/s00535-006-1983-y

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