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Do-not-resuscitate orders and related factors among family surrogates of patients in the emergency department

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Abstract

Purpose

The purpose of this study was to investigate the prevalence of do-not-resuscitate (DNR) orders and to identify relevant factors influencing the DNR decision-making process by patients’ surrogates in the emergency department (ED).

Methods

A prospective, descriptive, and correlational research design was adopted. A total of 200 surrogates of cancer or non-cancer terminal patients, regardless of whether they signed a DNR order, were recruited as subjects after physicians of the emergency department explained the patient’s conditions, advised on withholding medical treatment, and provided information on palliative care to all surrogates.

Results

Of the 200 surrogates, 23 % signed a DNR order for the patients. The demographic characteristics of patients and surrogates, the level of understanding of DNR orders, and factors of the DNR decision had no significant influence on the DNR decision. However, greater severity of disease (odds ratio (OR) = 1.38; 95 % confidence interval (CI) = 0.95–1.74), physician’s initiative in discussing with the families (OR = 1.42; 95 % CI = 1.21–1.84), and longer length of hospital stay (OR = 1.06; 95 % CI = 1.03–1.08) were contributing factors affecting patient surrogates’ DNR decisions.

Conclusions

The findings of this study indicated that surrogates of patients who were more severe in disease condition, whose physicians initiated the discussion of palliative care, and who stayed longer in hospital were important factors affecting the surrogates’ DNR decision-making. Therefore, early initiation of DNR discussions is suggested to improve end-of-life care.

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References

  1. Chan GK (2004) End-of-life models and emergency department care. Acad Emerg Med 11(1):79–86

    Article  PubMed  Google Scholar 

  2. Lawson BJ, Burge FI, McIntyre P, Field S, Maxwell D (2008) Palliative care patients in the emergency department. J Palliat Care 24(4):247–255

    PubMed  PubMed Central  Google Scholar 

  3. Weng L, Joynt GM, Lee A, Du B, Leung P, Peng J, Gomersall CD, Hu X, Yap HY, The Chinese Critical Care Ethics Group (2011) Attitudes towards ethical problems in critical care medicine: the Chinese perspective. Intensive Care Med 37(4):655–664

    Article  PubMed  Google Scholar 

  4. World Health Organization (2006) WHO definition of palliative care. Retrieved October 15, 2012, from http://www.who.int/cancer/palliative/definition/en/

  5. Norton SA, Hogan LA, Holloway RG, Temkin-Greener H, Buckley MJ, Quill TE (2007) Proactive palliative care in the medical intensive care unit: effects on length of stay for selected high-risk patients. Crit Care Med 35(6):1530–1535

    Article  PubMed  Google Scholar 

  6. Lilly CM, De Meo DL, Sonna LA, Haley KJ, Massaro AF, Wallace RF, Cody S (2000) An intensive communication intervention for the critically ill. Am J Med 109(6):469–475

    Article  CAS  PubMed  Google Scholar 

  7. Kizawa Y, Tsuneto S, Hamano J, Nagaoka H, Maeno T, Shima Y (2013) Advance directives and do-not-resuscitate orders among patients with terminal cancer in palliative care units in Japan: a nationwide survey. Am J Hosp Palliat Care 30(7):664–669

    Article  PubMed  Google Scholar 

  8. Tabak YP, Johannes RS, Silber JH, Kurtz SG (2005) Should do-not-resuscitate status be included as a mortality risk adjustor? The impact of DNR variations on performance reporting. Med Care 43(7):658–666

    Article  PubMed  Google Scholar 

  9. Cook DJ, Guyatt G, Rocker G, Sjokvist P, Weaver B, Dodek P, Marshall J, Leasa D, Levy M, Varon J, Fisher M, Cook R (2001) Cardiopulmonary resuscitation directives on admission to intensive-care unit: an international observational study. Lancet 358(9297):1941–1945

    Article  CAS  PubMed  Google Scholar 

  10. Voltz R, Akabayashi A, Reese C, Ohi G, Sass HM (1998) End-of-life decisions and advance directives in palliative care: a cross-cultural survey of patients and health-care professionals. J Pain Symptom Manag 16(3):153–162

    Article  CAS  Google Scholar 

  11. Becker G, Sarhatlic R, Olschewski M, Xander C, Momm F, Blum HE (2007) End-of-life care in hospital: current practice and potentials for improvement. J pain Symptom Manag 33(6):711–719

    Article  Google Scholar 

  12. Fins JJ, Miller FG, Acres CA, Bacchetta MD, Huzzard LL, Rapkin BD (1999) End-of-life decision-making in the hospital: current practice and future prospects. J pain Symptom Manag 17(1):6–15

    Article  CAS  Google Scholar 

  13. Keam B, Oh DY, Lee SH, Kim DW, Kim MR, Im SA, Kim TY, Bang YJ, Heo DS (2008) Aggressiveness of cancer-care near the end-of-life in Korea. Jpn J Clin Oncol 38(5):381–386

    Article  PubMed  Google Scholar 

  14. Llovera I, Ward MF, Ryan JG, Lesser M, Sama AE, Crough D, Mansfield M, Lesser LI (1999) Why don’t emergency department patients have advance directives? Acad Emerg Med 6(10):1054–1060

    Article  CAS  PubMed  Google Scholar 

  15. Huang CH, Hu WY, Chiu TY, Chen CY (2008) The practicalities of terminally ill patients signing their own DNR orders--a study in Taiwan. J Med Ethics 34(5):336–340

    Article  PubMed  Google Scholar 

  16. Wen KY, Lin YC, Cheng JF, Chou PC, Wei CH, Chen YF, Sun JL (2013) Insights into Chinese perspectives on do-not-resuscitate (DNR) orders from an examination of DNR order form completeness for cancer patients. Support Care Cancer 21(9):2593–2598

    Article  PubMed  PubMed Central  Google Scholar 

  17. Tang ST, Liu TW, Lai MS, Liu LN, Chen CH (2005) Concordance of preferences for end-of-life care between terminally ill cancer patients and their family caregivers in Taiwan. J Pain Symptom Manag 30(6):510–518

    Article  Google Scholar 

  18. Hakim RB, Teno JM, Harrell FE, Knaus WA, Wenger N, Phillips RS, Layde P, Califf RM, Connors JF, Lynn J (1996) Factors associated with do-not-resuscitate orders: patients’ preferences, prognoses, and physicians’ judgments. Ann Intern Med 125(4):284–293

    Article  CAS  PubMed  Google Scholar 

  19. de Decker L, Annweiler C, Launay C, Fantino B, Beauchet O (2014) Do not resuscitate orders and aging: impact of multimorbidity on the decision-making process. J Nutr Health Aging 18(3):330–335

    Article  PubMed  Google Scholar 

  20. Chang Y, Huang CF, Lin CC (2010) Do-not-resuscitate orders for critically ill patients in intensive care. Nurs Ethics 17(4):445–455

    Article  PubMed  Google Scholar 

  21. Nakano K, Yoshida T, Furutama J, Sunada S (2012) Quality of end-of-life care for patients with metastatic non-small-cell lung cancer in general wards and palliative care units in Japan. Support Care Cancer 20(4):883–888

    Article  PubMed  Google Scholar 

  22. Levy CR, Fish R, Kramer A (2005) Do-not-resuscitate and do-not-hospitalize directives of persons admitted to skilled nursing facilities under the Medicare benefit. J Am Geriatr Soc 53(12):2060–2068

    Article  PubMed  Google Scholar 

  23. White DB, Engelberg RA, Wenrich MD, Lo B, Curtis JR (2007) Prognostication during physician-family discussions about limiting life support in intensive care units. Crit Care Med 35(2):442–448

    Article  PubMed  Google Scholar 

  24. Lamba S, Quest TE (2011) Hospice care and the emergency department: rules regulations, and referrals. Ann Emerg Med 57(3):282–290

    Article  PubMed  Google Scholar 

  25. Faul F, Erdfelder E, Lang AG, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39(2):175–191

    Article  PubMed  Google Scholar 

  26. Le Conte P, Riochet D, Batard E, Volteau C, Giraudeau B, Arnaudet I, Labastire L, Levraut J, Thys F, Lauque D, Piva C, Schmidt J, Trewick D, Potel G (2010) Death in emergency departments: a multicenter cross-sectional survey with analysis of withholding and withdrawing life support. Intensive Care Med 36(5):765–772

    Article  PubMed  Google Scholar 

  27. Quest TE, Marco CA, Derse AR (2009) Hospice and palliative medicine: new subspecialty, new opportunities. Ann Emerg Med 54(1):94–102

    Article  PubMed  Google Scholar 

  28. Heyland DK, Tranmer J, Feldman-Stewart D (2000) End-of-life decision making in the seriously ill hospitalized patient: an organizing framework and results of a preliminary study. J Palliat Care 16:S31–39

    PubMed  Google Scholar 

  29. Hsin DHC, Macer D (2006) Comparisons of life images and end-of-life attitudes between the elderly in Taiwan and New Zealand. J Nurs Res 14(3):198–208

    Article  PubMed  Google Scholar 

  30. Van der Heide A, Deliens L, Faisst K, Nilstun T, Norup M, Paci E, van der Wal G, van der Maas PJ (2003) End-of-life decision-making in six European countries: descriptive study. Lancet 362(9381):345–350

    Article  PubMed  Google Scholar 

  31. Fujimoto K, Minami S, Yamamoto S, Ogata Y, Koba T, Futami S, Nishijima Y, Yaga M, Masuhiro K, Komuta K (2014) Comparison of timing and decision-makers of do-not-resuscitate orders between thoracic cancer and non-cancer respiratory disease patients dying in a Japanese. Support Care Cancer 22(6):1485–1492

    Article  PubMed  Google Scholar 

  32. Chiu TY, Hu WY, Chen CY (2000) Prevalence and severity of symptoms in terminal cancer patients: a study in Taiwan. Support Care Cancer 8(4):311–313

    Article  CAS  PubMed  Google Scholar 

  33. Truog RD, Cist AF, Brackett SE, Burns JP, Curley MA, Danis M, DeVita MA, Rosenbaum SH, Rothenberg DM, Sprung CL, Webb SA, Wlody GS, Hurford WE (2001) Recommendations for end-of-life care in the intensive care unit: the ethics committee of the society of critical care medicine. Crit Care Med 29(12):2332–2348

    Article  CAS  PubMed  Google Scholar 

  34. Wenger NS, Pearson ML, Desmond KA, Harrison ER, Rubenstein LV, Rogers WH, Kahn KL (1995) Epidemiology of do-not-resuscitate orders. Disparity by age, diagnosis, gender, race, and functional impairment. Arch Intern Med 155(19):2056–2062

    Article  CAS  PubMed  Google Scholar 

  35. Alsirafy SA, Raheem AA, Al-Zahrani AS, Mohammed AA, Sherisher MA, El-Kashif AT, Ghanem HM (2015) Emergency department visits at the end of life of patients with terminal cancer: pattern, causes, and avoidability. Am J Hosp Palliat Care 1–5

  36. Mendes A, Carvalho F, Dias C, Granja C (2009) In-hospital cardiac arrest: factors in the decision not to resuscitate. The impact of an organized in-hospital emergency system. Rev Port Cardiol 28(2):131–141

    PubMed  Google Scholar 

  37. Kim DY, Lee KE, Nam EM, Lee HR, Lee KW, Kim JH, Lee JS, Lee SN (2007) Do-not-resuscitate orders for terminal patients with cancer in teaching hospitals of Korea. J Palliat Med 10(5):1153–1158

    Article  PubMed  Google Scholar 

  38. Gouda A, Al-Jabbary A, Fong L (2010) Compliance with DNR policy in a tertiary care center in Saudi Arabia. Intensive Care Med 36(12):2149–2153

    Article  PubMed  Google Scholar 

  39. Baggs JG, Norton SA, Schmitt MH, Dombeck MT, Sellers CR, Quinn JR (2007) Intensive care unit cultures and end-of-life decision making. J Crit Care 22(2):159–168

    Article  PubMed  PubMed Central  Google Scholar 

  40. Collins N, Phelan D, Marsh B, Sprung CL (2006) End-of-life care in the intensive care unit: the Irish ethicus data. Crit Care Resusc 8(4):315–320

    PubMed  Google Scholar 

  41. Parsons HA, de la Cruz MJ, Zhukovsky DS, Hui D, Delgado-Guay MO, Akitoye AE, Bel O, Palmer L, Palla MSc SL, Bruera E (2010) Characteristics of patients who refuse do-not-resuscitate orders upon admission to an acute palliative care unit in a comprehensive cancer center. Cancer 116(12):3061–3070

    Article  PubMed  Google Scholar 

  42. Santana-Cabrera L, Sánchez-Palacios M, Escot CR, Rodríguez AU, Zborovszky E, Pérez JO (2015) Comparative study on the prognosis of critical ill patients transferred from another island compared to those patients transferred from emergency department to intensive care unit. Int J Crit Illn Inj Sci 5(2):85–88

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

We would like to extend our thanks to the Chang Gung Memorial Hospital, Kaohsiung Medical Center, for its financial support of this research project (CMRPG8A0221), to the ED, and to all participating patients and families.

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Correspondence to Chao-Hui Su.

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The authors declare that no conflict of interest exists with regard to this study.

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Cheng, YH., Wang, JJ., Wu, KH. et al. Do-not-resuscitate orders and related factors among family surrogates of patients in the emergency department. Support Care Cancer 24, 1999–2006 (2016). https://doi.org/10.1007/s00520-015-2971-7

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  • DOI: https://doi.org/10.1007/s00520-015-2971-7

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