Skip to main content

Advertisement

SpringerLink
Log in

The influence of comorbid chronic diseases and physical activity on quality of life in lung cancer survivors

  • Original Article
  • Published:
Supportive Care in Cancer Aims and scope Submit manuscript

Abstract

Purpose

This study aimed to evaluate the influence of comorbid chronic diseases (CCD) and physical activity (PA) on quality of life (QOL) in lung cancer survivors (LCSs).

Methods

The study used a cross-sectional study design. A total of 701 LCSs were recruited from 17 comprehensive cancer rehabilitation clubs in Shanghai, China. Measurements used included the European Organization for Research and Treatment quality of life version 3 questionnaire (EORTC QLQ-C30) and the Functional Assessment of Cancer Therapy -General version 4 questionnaire (FACT-G). Independent variables were CCD and PA. Multiple linear regression models were used to control for the effect of sociodemographic characteristic.

Results

Subjects with CCD generally reported lower scores for most EORTC QLQ-C30 and FACT-G scales when compared to subjects without CCD, indicating poorer QOL. Subjects with PA generally reported higher scores for most EORTC QLQ-C30 and FACT-G scales when compared to subjects without PA, indicating better QOL. The influences of five times and more PA per week were larger than the influence of less than five times PA per week. Subjects without CCD and with PA generally reported similar scores for most EORTC QLQ-C30 and FACT-G scales when compared to others without CCD and PA. Subjects with CCD and PA generally reported higher scores for most EORTC QLQ-C30 and FACT-G scales when compared to other LCSs with CCD and without PA.

Conclusions

CCD have significantly negative influence on QOL. PA has significantly positive influence on QOL among the LCSs with CCD, not among the other LCSs without CCD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. She J, Yang P, Hong Q, Bai CX (2013) Lung cancer in China: challenges and interventions. Chest 143:1117–1126

    Article  PubMed  Google Scholar 

  2. Office for National Statistics (2011) Cancer survival in England: patients diagnosed 2005–2009 and followed up to 2010. ONS, London

    Google Scholar 

  3. Claassens L, van Meerbeeck J, Coens C et al (2011) Health-related quality of life in non-small-cell lung cancer: an update of a systematic review on methodologic issues in randomized controlled trials. J Clin Oncol 20:2101–2120

    Google Scholar 

  4. Balduyck B, Hendriks J, Lauwers P, Van Schil P (2008) Quality of life after lung cancer surgery: a prospective pilot study comparing bronchial sleeve lobectomy with pneumonectomy. J Thorac Oncol 3:604–608

    Article  PubMed  Google Scholar 

  5. Ediebah DE, Coens C, Zikos E et al (2014) Does change in health-related quality of life score predict survival? Analysis of EORTC 08975 lung cancer trial. Br J Cancer 110:2427–2433

    Article  CAS  PubMed  Google Scholar 

  6. Janssen-Heijnen ML, Schipper RM, Razenberg PP, Crommelin MA, Coebergh JW (1998) Prevalence of co-morbidity in lung cancer patients and its relationship with treatment: a population-based study. Lung Cancer 21:105–113

    Article  CAS  PubMed  Google Scholar 

  7. Ogle KS, Swanson GM, Woods N, Azzouz F (2000) Cancer and comorbidity: redefining chronic diseases. Cancer 88:653–663

    Article  CAS  PubMed  Google Scholar 

  8. Battafarano RJ, Piccirillo JF, Meyers BF et al (2002) Impact of comorbidity on survival after surgical resection in patients with stage I non-small cell lung cancer. J Thorac Cardiovasc Surg 123:280–287

    Article  PubMed  Google Scholar 

  9. Tammemagi CM, Neslund-Dudas C, Simoff M, Kvale P (2003) Impact of comorbidity on lung cancer survival. Int J Cancer 103:792–802

    Article  CAS  PubMed  Google Scholar 

  10. Knols R, Aaronson NK, Uebelhart D, Fransen J, Aufdemkampe G (2005) Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials. J Clin Oncol 23:3830–3842

    Article  PubMed  Google Scholar 

  11. Schmitz KH, Holtzman J, Courneya KS, Masse LC, Duval S, Kane R (2005) Controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 14:1588–1599

    Article  PubMed  Google Scholar 

  12. Aaronson NK, Ahmedzai S, Bergman B et al (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality of life instrument for use in international clinical trials in oncology. J Nat Cancer Inst 85:364–376

    Article  Google Scholar 

  13. Cella DF, Tulsky DS, Gray G et al (1993) The functional assessment of cancer therapy scale: development and validation of the general measure. J Clin Oncol 11:570–579

    CAS  PubMed  Google Scholar 

  14. Kemmler G, Holzner B, Kopp M et al (1999) Comparison of two quality-of-life instruments for cancer patients: the functional assessment of cancer therapy-general and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30. J Clin Oncol 17:2932–2940

    CAS  PubMed  Google Scholar 

  15. Holzner B, Bode RK, Hahn EA et al (2006) Equating EORTC QLQ-C30 and FACT-G scores and its use in oncological research. Eur J Cancer 42:3169–3177

    Article  CAS  PubMed  Google Scholar 

  16. Montazeri A, Hole DJ, Milroy R, McEwen J, Gillis CR (2003) Quality of life in lung cancer patients: does socioeconomic status matter? Health Qual Life Outcomes 1:19

    Article  PubMed Central  PubMed  Google Scholar 

  17. Jordhøy MS, Fayers P, Loge JH, Saltnes T, Ahlner-Elmqvist M, Kaasa S (2001) Quality of life in advanced cancer patients: the impact of sociodemographic and medical characteristics. Br J Cancer 85:1478–1485

    Article  PubMed Central  PubMed  Google Scholar 

  18. Seshasai SR, Kaptoge S, Thompson A et al (2011) Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 364:829–841

    Article  CAS  PubMed  Google Scholar 

  19. Tammemagi CM, Neslund-Dudas C, Simoff M, Kvale P (2003) Impact of comorbidity on lung cancer survival. Int J Cancer 103:792–802

    Article  CAS  PubMed  Google Scholar 

  20. Demark-Wahnefried W, Aziz NM, Rowland JH, Pinto BM (2005) Riding the crest of the teachable moment: promoting long-term health after the diagnosis of cancer. J Clin Oncol 23:5814–5830

    Article  PubMed Central  PubMed  Google Scholar 

  21. Eakin EG, Youlden DR, Baade PD et al (2007) Health behaviors of cancer survivors: data from an Australian population-based survey. Cancer Causes Control 18:881–894

    Article  PubMed  Google Scholar 

  22. Broderick JM, Hussey J, Kennedy MJ, O'Donnell D (2014) Testing the ‘teachable moment’ premise: does physical activity increase in the early survivorship phase? Support Care Cancer 22:989–997

    Article  CAS  PubMed  Google Scholar 

  23. Fisher EB, Brownson CA, O’Toole ML, Shetty G, Anwuri VV, Glasgow RE (2005) Ecological approaches to self-management: the case of diabetes. Am J Public Health 95:1523–1535

    Article  PubMed Central  PubMed  Google Scholar 

  24. McCorkle R, Ercolano E, Lazenby M et al (2011) Self-management: enabling and empowering patients living with cancer as a chronic illness. CA Cancer J Clin 61:50–62

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgments

We would like to thank the Shanghai Cancer Rehabilitation Club for supporting this study. We are very grateful to all lung cancer survivors who willingly and generously gave their time.

Funding

This study was supported by grants from the National Social Science Foundation of China (Award Number 13CSH076) and Shanghai Municipal Commission of Health and Family Planning (Award Number 20134068).

Conflict of interest

The authors declare no conflict of interest.

Author information

Authors and Affiliations

  1. School of Public Health, Fudan University, Dong-An Road, Shanghai, 200032, People’s Republic of China

    Ji-Wei Wang, Xiong-Huan Gong, Xue-Fen Chen, Li Sun, Zheng Tang & Jin-Ming Yu

  2. Centre for Research and Action in Public Health, The University of Canberra, Canberra, Australian Capital Territory, Australia

    Ning Ding

  3. College of Clinical Medicine, Anhui Medical University, Hefei, Anhui Province, 230601, People’s Republic of China

    Dong-Hui Yu

  4. Shanghai Cancer Rehabilitation Club, 2795 Yang-Gao-Nan Road, Shanghai, 200135, People’s Republic of China

    Zheng-Ping Yuan

  5. Zhongshan Hospital, Fudan University, 180 Feng-Lin Road, Shanghai, 200032, People’s Republic of China

    Xiang-Dong Wang

Authors
  1. Ji-Wei Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiong-Huan Gong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ning Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xue-Fen Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Li Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Zheng Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Dong-Hui Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Zheng-Ping Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Xiang-Dong Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Jin-Ming Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Xiang-Dong Wang or Jin-Ming Yu.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, JW., Gong, XH., Ding, N. et al. The influence of comorbid chronic diseases and physical activity on quality of life in lung cancer survivors. Support Care Cancer 23, 1383–1389 (2015). https://doi.org/10.1007/s00520-014-2494-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00520-014-2494-7

Keywords

Search

Navigation