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Evaluation of left ventricular functions in patients with primary hyperparathyroidism: is there any effect of parathyroidectomy?

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Summary

Purpose

Our aim was to evaluate left ventricular (LV) systolic and diastolic functions of primary hyperparathyroidism (pHPT) patients with detailed echocardiographic analysis and investigate the effect of parathyroidectomy on echocardiographic parameters.

Methods

A total of 22 eligible consecutive patients with pHPT who underwent parathyroidectomy operation were recruited to the study. Another 22 subjects with similar age, gender and frequency of cardiovascular risk factors compared to patients were used as a control group. Echocardiographic parameters of patients scheduled for parathyroidectomy were compared to healthy matched controls. Echocardiographic parameters measured 6 months after the operation were also compared with preoperative values for each patient.

Results

Patients had higher LV mass index compared with controls. There were no significant differences between groups regarding 2D echocardiographic parameters reflecting LV systolic function and tissue Doppler velocities; however, 2D echocardiographic parameters demonstrated impairment in LV diastolic functions compared with controls. Speckle tracking echocardiography (STE) demonstrated similar LV global longitudinal systolic strain; however, left atrial conduit and reservoir functions were significantly reduced in patients with pHPT. In general, there were no significant differences between baseline and postoperative state regarding parameters reflecting LV systolic and diastolic functions; however, STE demonstrated significantly increased LV global longitudinal strain after surgery (22.3 ± 3.3% vs 20.3 ± 2.9%, p = 0.026).

Conclusion

Patients with pHPT displayed higher LV mass and impairment in LV diastolic function compared with controls. Parathyroidectomy did not lead to significant improvements in LV mass or LV diastolic function; however, subtle but not apparent increases in LV systolic function were observed 6 months after surgery.

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Acknowledgements

Authors would like to thank to Sengul Polat for her contributions to the study.

Author information

Authors and Affiliations

  1. Cardiology Clinic, Marmara University Training and Research Hospital, Istanbul, Turkey

    Alper Kepez

  2. Endocrinology Clinic, Marmara University Training and Research Hospital, Istanbul, Turkey

    Mehmet Yasar MD

  3. Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey

    Murat Sunbul, Cigdem Ileri MD,  Bulent Mutlu,  Osman Yesildag &  Yelda Basaran

  4. Department of Internal Medicine, Division of Endocrinology, Marmara University Faculty of Medicine, Istanbul, Turkey

    Oguzhan Deyneli

Authors
  1. Alper Kepez
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  2. Mehmet Yasar MD
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  3. Murat Sunbul
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  4. Cigdem Ileri MD
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  5. Oguzhan Deyneli
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  6. Bulent Mutlu
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  8. Yelda Basaran
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Corresponding author

Correspondence to Alper Kepez.

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Conflict of interest

A. Kepez, M. Yasar, M. Sunbul, C. Ileri, O. Deyneli, B. Mutlu, O. Yesildag, and Y. Basaran declare that they have no competing interests.

Ethical standards

All procedures performed in our study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Ethics committee of Marmara University Faculty of Medicine, Istanbul, Turkey approved the study protocol on 03.04.2015 with protocol number 09.2015.007. Written informed consent was obtained from all participants.

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Kepez, A., Yasar, M., Sunbul, M. et al. Evaluation of left ventricular functions in patients with primary hyperparathyroidism: is there any effect of parathyroidectomy?. Wien Klin Wochenschr 129, 329–336 (2017). https://doi.org/10.1007/s00508-017-1186-y

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  • DOI: https://doi.org/10.1007/s00508-017-1186-y

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