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The hemodynamics in intracranial aneurysm ruptured region with active contrast leakage during computed tomography angiography

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Abstract

Precise locations of rupture region under contrast agent leakage of five ruptured cerebral artery aneurysms during computed tomography angiography, which is to our knowledge for the first time, were successfully identified among 101 patients. These, together with numerical simulations based on the reconstructed aneurysmal models, were used to analyze hemodynamic parameters of aneurysms under different cardiac cyclic flow rates. For side wall type aneurysms, different inlet flow rates have mild influences on the shear stresses distributions. On the other hand, for branch type aneurysms, the predicted wall shear stress (WSS) correlates strongly with the increase of inlet vessel velocity. The mean and time averaged WSSes at rupture regions are found to be lower than those over the surface of the aneurysms. Also, the levels of the oscillatory shear index (OSI) are higher than the reported threshold value, supporting the assertion that high OSI correlates with rupture of the aneurysm. However, the present results also indicate that OSI level at the rupture region is relatively lower.

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Acknowledgments

The authors gratefully acknowledge the support of the Joint Research Program of Chang-Gung Memorial Hospital and National Tsing Hua University in Taiwan under grant 102N2784E1, National Science Council under grant NSC99-2212-E007-032-MY3, and the computational facilities provided by the National Center for High-Performance Computing of Taiwan.

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Authors and Affiliations

  1. National Center for High-Performance Computing, Hsinchu, 300, Taiwan

    Ming-Lung Li

  2. Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Yi-Chou Wang

  3. Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, 30013, Taiwan

    Ming-Lung Li, Tong-Miin Liou & Chao-An Lin

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  1. Ming-Lung Li
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  2. Yi-Chou Wang
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Correspondence to Chao-An Lin.

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Li, ML., Wang, YC., Liou, TM. et al. The hemodynamics in intracranial aneurysm ruptured region with active contrast leakage during computed tomography angiography. Comput Mech 54, 987–997 (2014). https://doi.org/10.1007/s00466-014-0993-5

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  • DOI: https://doi.org/10.1007/s00466-014-0993-5

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