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Identification of an autosomal recessive stuttering locus on chromosome 3q13.2–3q13.33

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Abstract

Stuttering is a common speech disorder with substantial genetic contributions. To better understand the genetic factors involved in stuttering, we performed a genome-wide linkage study in a newly-ascertained consanguineous stuttering family from Pakistan. A linkage scan in this family using parametric linkage analysis revealed significant linkage only on chromosome 3q13.2–3q13.33, with a maximum two-point LOD score of 4.23 under an autosomal recessive model of inheritance.

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Acknowledgments

We thank Ms. Bushra Raza for assistance with stuttering diagnosis, and the research subjects for their generous cooperation with this study.

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Author notes

  1. Sheikh Riazuddin

    Present address: Allama Iqbal Medical College, Lahore, Pakistan

Authors and Affiliations

  1. National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA

    Muhammad Hashim Raza & Dennis Drayna

  2. Center of Excellence in Molecular Biology, Punjab University, Lahore, Pakistan

    Muhammad Hashim Raza & Sheikh Riazuddin

  3. NIDCD/NIH, 5 Research Court, Rockville, MD, 20850, USA

    Dennis Drayna

Authors
  1. Muhammad Hashim Raza
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  2. Sheikh Riazuddin
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  3. Dennis Drayna
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Correspondence to Dennis Drayna.

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Raza, M.H., Riazuddin, S. & Drayna, D. Identification of an autosomal recessive stuttering locus on chromosome 3q13.2–3q13.33. Hum Genet 128, 461–463 (2010). https://doi.org/10.1007/s00439-010-0871-y

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  • DOI: https://doi.org/10.1007/s00439-010-0871-y

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