Molecular Genetics and Genomics

, Volume 290, Issue 4, pp 1357–1365

Associations between TRPV4 genotypes and body mass index in Taiwanese subjects

  • De-Min Duan
  • Semon Wu
  • Lung-An Hsu
  • Ming-Sheng Teng
  • Jeng-Feng Lin
  • Yu-Chen Sun
  • Ching-Feng Cheng
  • Yu-Lin Ko
Original Paper

DOI: 10.1007/s00438-015-0996-8

Cite this article as:
Duan, DM., Wu, S., Hsu, LA. et al. Mol Genet Genomics (2015) 290: 1357. doi:10.1007/s00438-015-0996-8

Abstract

Body weight regulation is influenced neuronally via the hypothalamus, which strongly expresses TRPV4. TRPV4 deficiency in mice confers resistance against diet-induced obesity. We investigated the association between TRPV4 gene variants and body mass index (BMI) in Taiwanese subjects. A sample population of 617 Taiwanese subjects was enrolled, and ten TRPV4 gene polymorphisms were selected and genotyped. After adjusting for clinical covariates, significant associations were observed between three studied polymorphisms and BMI using a dominant model (P = 4.83 × 10−4, P = 1.17 × 10−4, and P = 3.37 × 10−4 for rs3742037, rs10735104, and rs3742035, respectively). Obesity as defined according to both the Asian and National Institutes of Health (NIH) criteria was significantly associated with rs10735104 (P = 0.003 and P = 0.037, respectively) in a dominant model. Genotypes at the TRPV4 locus independently affect BMI and obesity status in Taiwanese subjects. This association may broaden our understanding of the role of neuronal influence on body weight regulation. The regulation of TRPV4 channels in skeletal muscle and adipose tissue could also be a new therapeutic target for preventing the development of obesity.

Keywords

Body mass index Single nucleotide polymorphism Genetics Obesity Population studies 

Abbreviations

SNPs

Single nucleotide polymorphisms

BMI

Body mass index

GWAS

Genome-wide association studies

TRP

Transient receptor potential

TRPV4

Transient receptor potential vanilloid subtype 4

NIH

National Institutes of Health

ELISA

Enzyme-linked immunosorbent assay

HDL

High-density lipoprotein

LDL

Low-density lipoprotein

Supplementary material

438_2015_996_MOESM1_ESM.doc (69 kb)
Supplementary material 1 (DOC 69 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • De-Min Duan
    • 1
  • Semon Wu
    • 2
    • 4
  • Lung-An Hsu
    • 5
    • 6
  • Ming-Sheng Teng
    • 2
  • Jeng-Feng Lin
    • 1
  • Yu-Chen Sun
    • 7
  • Ching-Feng Cheng
    • 8
    • 3
  • Yu-Lin Ko
    • 1
    • 2
    • 3
  1. 1.Division of Cardiology, Department of Internal Medicine and The Cardiovascular Medical Center, Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei CityTaiwan, ROC
  2. 2.Department of Research, Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei CityTaiwan, ROC
  3. 3.Tzu Chi University College of MedicineHualienTaiwan
  4. 4.Department of Life ScienceChinese Culture UniversityTaipeiTaiwan
  5. 5.The First Cardiovascular Division, Department of Internal MedicineChang Gung Memorial HospitalTaipeiTaiwan
  6. 6.Chang Gung University College of MedicineTaipeiTaiwan
  7. 7.Department of Laboratory MedicineChang Gung Memorial HospitalTaipeiTaiwan
  8. 8.Department of PediatricsBuddhist Tzu Chi General HospitalHualienTaiwan

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